{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:03:56Z","timestamp":1775851436755,"version":"3.50.1"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>OBJECTIVE. In a previous multicenter, randomized trial, elective use of high-frequency oscillatory ventilation was compared with the use of conventional ventilation in the management of respiratory distress syndrome in preterm infants &amp;lt;30 weeks. No difference in terms of respiratory outcome was observed, but concerns were raised about an increased rate of severe intraventricular hemorrhage in the high-frequency ventilation group. To evaluate outcome, a follow-up study was conducted until a corrected age of 2 years. We report the results concerning neuromotor outcome.<\/jats:p>\n               <jats:p>METHODS. Outcome was able to be evaluated in 192 of the 212 infants who survived until discharge from the neonatal unit: 97 of 105 infants of the high-frequency group and 95 of 104 infants of the conventional ventilation group.<\/jats:p>\n               <jats:p>RESULTS. In the infants reviewed, mean birth weight and gestational age were similar in the 2 ventilation groups. As in the overall study population, the following differences were observed between the high-frequency ventilation group and the conventional ventilation group: lower 5-minute Apgar score, fewer surfactant instillations, and a higher incidence of severe intraventricular hemorrhage. At a corrected age of 2 years, 93 of the 97 infants of the high-frequency group and 79 of the 95 infants of the conventional ventilation group did not present any neuromotor disability, whereas 4 infants of the high-frequency group and 16 infants of the conventional ventilation group had cerebral palsy.<\/jats:p>\n               <jats:p>CONCLUSIONS. Contrary to our initial concern about the increased rate of severe intraventricular hemorrhage in the high-frequency ventilation group, these data suggest that early use of high-frequency ventilation, compared with conventional ventilation, may be associated with a better neuromotor outcome. Because of the small number of patients studied and the absence of any explanation for this finding, we can conclude only that high-frequency oscillatory ventilation is not associated with a poorer neuromotor outcome.<\/jats:p>","DOI":"10.1542\/peds.2006-2082","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T01:43:40Z","timestamp":1173145420000},"page":"e860-e865","source":"Crossref","is-referenced-by-count":23,"title":["Neuromotor Outcome at 2 Years of Very Preterm Infants Who Were Treated With High-Frequency Oscillatory Ventilation or Conventional Ventilation for Neonatal Respiratory Distress Syndrome"],"prefix":"10.1542","volume":"119","author":[{"given":"Patrick","family":"Truffert","sequence":"first","affiliation":[{"name":"Department of Neonatology, Lille University Hospital, Lille, France"},{"name":"INSERM U 149, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Paris-Llado","sequence":"additional","affiliation":[{"name":"INSERM U 149, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoi\u0302t","family":"Escande","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Strasbourg University Hospital, Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Franc\u0327ois","family":"Magny","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Institut de Pue\u0301riculture, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Cambonie","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Montpellier University Hospital, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Saliba","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Tours University Hospital, Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u0301rard","family":"Thiriez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Besanc\u0327on University Hospital, Besanc\u0327on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ve\u0301ronique","family":"Zupan-Simunek","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Antoine Be\u0301cle\u0300re University Hospital, Clamart, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Blanc","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Roze\u0301","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Nantes University Hospital, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u0301rard","family":"Bre\u0301art","sequence":"additional","affiliation":[{"name":"INSERM U 149, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Moriette","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Cochin Port-Royal University Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"2021120823310234200_R1","doi-asserted-by":"crossref","unstructured":"Moriette G, Paris-Lllado J, Walti H, et al. Prospective randomized multicenter comparison of high-frequency oscillatory ventilation and conventional ventilation in preterm infants of less than 30 weeks with respiratory distress syndrome. Pediatrics.\u20082001;107:363\u2013372","DOI":"10.1542\/peds.107.2.363"},{"key":"2021120823310234200_R2","doi-asserted-by":"crossref","unstructured":"Henderson-Smart D, Bhuta T, Cools F, Offringa M. Elective high-frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev.\u20082003;1:CD000104","DOI":"10.1002\/14651858.CD000104"},{"key":"2021120823310234200_R3","doi-asserted-by":"crossref","unstructured":"Courtney S, Durand D, Asselin J, Hudak M, Aschner J, Shoemaker C. High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight-infants. N Engl J Med.\u20082002;347:643\u2013652","DOI":"10.1056\/NEJMoa012750"},{"key":"2021120823310234200_R4","doi-asserted-by":"crossref","unstructured":"Johnson A, Peacock J, Greenough A, et al. High-frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity. N Engl J Med.\u20082002;347:633\u2013642","DOI":"10.1056\/NEJMoa020432"},{"key":"2021120823310234200_R5","doi-asserted-by":"crossref","unstructured":"Ment LR, Allan WC, Makuch WC, Vohr B. Grade 3 to 4 intraventricular hemorrhage and Bayley score predict outcome. Pediatrics.\u20082005;116:1597\u20131598","DOI":"10.1542\/peds.2005-2020"},{"key":"2021120823310234200_R6","doi-asserted-by":"crossref","unstructured":"Vohr BR, Allan WC, Westerveld M, et al. School-age outcome of very low birth weight infants in the Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics.\u20082003;111(4). Available at: www.pediatrics.org\/cgi\/content\/full\/111\/4\/e340","DOI":"10.1542\/peds.111.4.e340"},{"key":"2021120823310234200_R7","doi-asserted-by":"crossref","unstructured":"Schmidt B, Davis P, Moddemann D, et al. Long-term effects of indomethacin prophylaxis in extremely low birth weight infants. N Engl J Med.\u20082001;344:1966\u20131972","DOI":"10.1056\/NEJM200106283442602"},{"key":"2021120823310234200_R8","doi-asserted-by":"crossref","unstructured":"High-frequency oscillatory ventilation compared with conventional intermittent mechanical ventilation in the treatment of respiratory failure in preterm infants: neurodevelopmental status at 16 to 24 months of postterm age. The HIFI Study Group. J Pediatr.\u20081990;117:939\u2013946","DOI":"10.1016\/S0022-3476(05)80142-8"},{"key":"2021120823310234200_R9","doi-asserted-by":"crossref","unstructured":"Ogawa Y, Miyasaka K, Kawano T, et al. A multicenter randomized trial of high frequency oscillatory ventilation as compared with conventional mechanical ventilation in preterm infants with respiratory failure. Early Hum Dev.\u20081993;32:1\u201310","DOI":"10.1016\/0378-3782(93)90088-C"},{"key":"2021120823310234200_R10","doi-asserted-by":"crossref","unstructured":"Gerstmann DR, Wood K, Miller A, et al. Childhood outcome after high-frequency oscillatory ventilation for neonatal respiratory distress syndrome. Pediatrics\u20082001;108:617\u2013623","DOI":"10.1542\/peds.108.3.617"},{"key":"2021120823310234200_R11","doi-asserted-by":"crossref","unstructured":"Van Reempts P, Borstlap C, Laroche S, Van der Auwer J-C. Early use of high frequency ventilation in the premature neonate. Eur J Pediatr.\u20082003;162:219\u2013226","DOI":"10.1007\/s00431-002-1145-z"},{"key":"2021120823310234200_R12","doi-asserted-by":"crossref","unstructured":"High-frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants. The HIFI Study Group. N Engl J Med.\u20081989;320:88\u201393","DOI":"10.1056\/NEJM198901123200204"},{"key":"2021120823310234200_R13","doi-asserted-by":"crossref","unstructured":"Randomized study of high-frequency oscillatory ventilation in infants with severe respiratory distress syndrome. HiFO Study Group. J Pediatr\u20081993;122:609\u2013619","DOI":"10.1016\/S0022-3476(05)83548-6"},{"key":"2021120823310234200_R14","doi-asserted-by":"crossref","unstructured":"Rettwitz-Volk W, Veldman A, Roth B, et al. A prospective, randomized, multicenter trial of high-frequency oscillatory ventilation compared with conventional ventilation in preterm infants with respiratory distress syndrome receiving surfactant. J Pediatr.\u20081998;132:249\u2013254","DOI":"10.1016\/S0022-3476(98)70440-8"},{"key":"2021120823310234200_R15","doi-asserted-by":"crossref","unstructured":"Ancel P-Y, Livinec F, Larroque B, et al. Cerebral palsy among very preterm children in relation to gestational age and neonatal ultrasound abnormalities: the EPIPAGE Cohort Study. Pediatrics.\u20082006;117:828\u2013835","DOI":"10.1542\/peds.2005-0091"},{"key":"2021120823310234200_R16","doi-asserted-by":"crossref","unstructured":"Surveillance of Cerebral Palsy in Europe. Surveillance of cerebral palsy in Europe. a collaboration of cerebral palsy surveys and registers. Dev Med Child Neurol.\u20082000;42:816\u2013824","DOI":"10.1017\/S0012162200001511"},{"key":"2021120823310234200_R17","doi-asserted-by":"crossref","unstructured":"Jackson JC, Truog WE, Standaert TA, et al. Reduction in lung injury after combined surfactant and high-frequency ventilation. Am J Respir Crit Care Med.\u20081994;150:534\u2013539","DOI":"10.1164\/ajrccm.150.2.8049842"},{"key":"2021120823310234200_R18","doi-asserted-by":"crossref","unstructured":"Froese AB, McCulloch PR, Sugiura M, Vaclavik S, Possmayer F, Moller F. Optimizing alveolar expansion prolongs the effectiveness of exogenous surfactant therapy in the adult rabbit. Am Rev Respir Dis.\u20081993;148:569\u2013577","DOI":"10.1164\/ajrccm\/148.3.569"},{"key":"2021120823310234200_R19","doi-asserted-by":"crossref","unstructured":"Imai Y, Kawano T, Miyasaka K, Takata M, Imai T, Okuyama K. Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. Am J Respir Crit Care Med.\u20081994;150(pt 1):1550\u20131554","DOI":"10.1164\/ajrccm.150.6.7952613"},{"key":"2021120823310234200_R20","doi-asserted-by":"crossref","unstructured":"Takata M, Abe J, Tanaka H, et al. Intraalveolar expression of tumor necrosis factor-alpha gene during conventional and high-frequency ventilation. Am J Respir Crit Care Med.\u20081997;156:272\u2013279","DOI":"10.1164\/ajrccm.156.1.9607072"},{"key":"2021120823310234200_R21","doi-asserted-by":"crossref","unstructured":"Yoder BA, Siler-Khodr T, Winter VT, Coalson JJ. High-frequency oscillatory ventilation. Effects on lung function, mechanics, and airway cytokines in the immature baboon model for neonatal chronic lung disease. Am J Respir Crit Care Med.\u20082000;162:1867\u20131876","DOI":"10.1164\/ajrccm.162.5.9912145"},{"key":"2021120823310234200_R22","doi-asserted-by":"crossref","unstructured":"Thome U, Kossel H, Lipowsky G, et al. Randomized comparison of high-frequency ventilation with high-rate intermittent positive pressure ventilation in preterm infants with respiratory failure. J Pediatr.\u20081999;135:39\u201346","DOI":"10.1016\/S0022-3476(99)70325-2"},{"key":"2021120823310234200_R23","doi-asserted-by":"crossref","unstructured":"Allan WC, Vohr B, Makuch RW, Katz KH, Ment LR. Antecedent of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. Arch Pediatr Adolesc Med.\u20081997;151:580\u2013585","DOI":"10.1001\/archpedi.1997.02170430046010"},{"key":"2021120823310234200_R24","doi-asserted-by":"crossref","unstructured":"Volpe JJ. Cerebral white matter injury of the premature infant: more common than you think. Pediatrics.\u20082003;112:176\u2013180","DOI":"10.1542\/peds.112.1.176"},{"key":"2021120823310234200_R25","doi-asserted-by":"crossref","unstructured":"De Vries LS, Van Haastert IL, Rademaker KJ, Koopman C, Groenendaal F. Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. J Pediatr.\u20082004;144:815\u2013820","DOI":"10.1016\/j.jpeds.2004.03.034"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/119\/4\/e860\/1118935\/zpe0040700e860.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/119\/4\/e860\/1118935\/zpe0040700e860.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:11:38Z","timestamp":1639023098000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/119\/4\/e860\/70156\/Neuromotor-Outcome-at-2-Years-of-Very-Preterm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,4,1]]},"published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2006-2082","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,1]]}}}