{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:38:49Z","timestamp":1790811529413,"version":"4.1.0"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:p>OBJECTIVES. In the past decade, neonatal special care services in China have been established, during which time various therapies for neonatal respiratory failure have been introduced. The objective of this study was to investigate the incidence, management, outcome, and cost of neonatal respiratory failure treated by mechanical ventilation in 23 tertiary NICUs of major hospitals in southeastern and midwestern China.<\/jats:p>\n                  <jats:p>METHODS. Data were collected over 12 consecutive months from 2004 to 2005 for neonates with neonatal respiratory failure. Eligible infants were those who required endotracheal intubation and mechanical ventilation and\/or nasal continuous positive airway pressure for at least 24 hours and infants who died within 24 hours of ventilation during their first 7 days of life. Data characterized demographics, antenatal and perinatal history, illness severity score, primary disease, respiratory care, complications, survival, and clinical burden.<\/jats:p>\n                  <jats:p>RESULTS. From a total of 13070 NICU admissions, there were 1722 (13.2%) cases of neonatal respiratory failure with respiratory distress syndrome, pneumonia\/sepsis, and meconium aspiration syndrome as major causes. For infants who survived until discharge, the median length of ventilation was 70 hours. Overall, in-hospital mortality for neonatal respiratory failure was 32.1%. Logistic regressions showed that lower gestational age, vaginal delivery, fetal distress before delivery, presence of a major anomaly, and high severity score in preterm infants were associated with an increased risk for death. In term and postterm infants, only the presence of a major anomaly and a high severity score were significant risk factors for death. Mean length and cost of stay in hospital were 19.2 \u00b1 14.6 days and 14966 \u00b1 13465 Yuan in the survivors.<\/jats:p>\n                  <jats:p>CONCLUSIONS. Neonatal respiratory failure in the NICU of the provincial cities of China has high mortality and cost that are linked to geographic variability, a male predominance, and low proportion of very preterm infants, characteristic of sociocultural confounding background.<\/jats:p>","DOI":"10.1542\/peds.2006-2426","type":"journal-article","created":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T10:30:12Z","timestamp":1209637812000},"page":"e1115-e1124","source":"Crossref","is-referenced-by-count":54,"title":["Neonatal Respiratory Failure: A 12-Month Clinical Epidemiologic Study From 2004 to 2005 in China"],"prefix":"10.1542","volume":"121","author":[{"given":"Liling","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Provincial Children's Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzhu","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Xi'An Children's Hospital, Xi'An, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Provincial Maternity Hospital, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Suzhou Women and Children's Health Center, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Yuying Children's Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Provincial Maternity Hospital, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Provincial Maternity Hospital, Xi'An, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Shenzhen Children's Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Chinese Collaborative Study Group for Neonatal Respiratory Diseases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"2021120908252759700_R1","doi-asserted-by":"crossref","unstructured":"Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants 1991\u20131999. Pediatrics.\u20082002;110(1 pt 1):143\u2013151","DOI":"10.1542\/peds.110.1.143"},{"key":"2021120908252759700_R2","doi-asserted-by":"crossref","unstructured":"Markestad T, Kaaresen PI, Ronnestad A, et al. Early death, morbidity, and need of treatment among extremely premature infants. Pediatrics.\u20082005;115(5):1289\u20131298","DOI":"10.1542\/peds.2004-1482"},{"key":"2021120908252759700_R3","doi-asserted-by":"crossref","unstructured":"Rubaltelli FF, Bonafe L, Tangucci M, Spagnolo A, Dani C. Epidemiology of neonatal acute respiratory disorders: a multicenter study on incidence and fatality rates of neonatal acute respiratory disorders according to gestational age, maternal age, pregnancy complications and type of delivery. Italian Group of Neonatal Pneumology. Biol Neonate.\u20081998;74(1):7\u201315","DOI":"10.1159\/000014005"},{"key":"2021120908252759700_R4","doi-asserted-by":"crossref","unstructured":"Angus DC, Linde-Zwirble WT, Clermont G, Griffin MF, Clark RH. Epidemiology of neonatal respiratory failure in the United States: projections from California and New York. Am J Respir Crit Care Med.\u20082001;164(7):1154\u20131160","DOI":"10.1164\/ajrccm.164.7.2012126"},{"key":"2021120908252759700_R5","doi-asserted-by":"crossref","unstructured":"Lee SK, McMillan DD, Ohlsson A, et al. Variation in practice and outcome in the Canadian network: 1996\u20131997. Pediatrics.\u20082000;106(5):1070\u20131079","DOI":"10.1542\/peds.106.5.1070"},{"key":"2021120908252759700_R6","doi-asserted-by":"crossref","unstructured":"Horbar JD. The Vermont Oxford Network: evidence-based quality improvement for neonatology. Pediatrics.\u20081999;103(1 Suppl E):350\u2013359","DOI":"10.1542\/peds.103.SE1.350"},{"key":"2021120908252759700_R7","doi-asserted-by":"crossref","unstructured":"Bennett CC, Johnson A, Field DJ. A comparison of clinical variables that predict adverse outcome in term infants with severe respiratory failure randomised to a policy of extracorporeal membrane oxygenation or to conventional neonatal intensive care. J Perinat Med.\u20082002;30(3):225\u2013230","DOI":"10.1515\/JPM.2002.031"},{"key":"2021120908252759700_R8","doi-asserted-by":"crossref","unstructured":"Richardson DK, Corcoran JD, Escobar GJ, Lee SK. SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores. J Pediatr.\u20082001;138(1):92\u2013100","DOI":"10.1067\/mpd.2001.109608"},{"key":"2021120908252759700_R9","doi-asserted-by":"crossref","unstructured":"Dubowitz LMS, Dubowitz V, Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr.\u20081970;77(1):1\u201310","DOI":"10.1016\/S0022-3476(70)80038-5"},{"key":"2021120908252759700_R10","unstructured":"Taeusch HW, Ballard RA. Avery's Diseases of the Newborn. 7th ed. Philadelphia, PA: WB Saunders; 1998"},{"key":"2021120908252759700_R11","doi-asserted-by":"crossref","unstructured":"Rubaltelli FF, Dani C, Reali MF, et al. Acute neonatal respiratory distress in Italy: a one-year prospective study. Italian Group of Neonatal Pneumology. Acta Paediatr.\u20081998;87(12):1261\u20131268","DOI":"10.1111\/j.1651-2227.1998.tb00949.x"},{"key":"2021120908252759700_R12","doi-asserted-by":"crossref","unstructured":"Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med.\u20082001;163(7):1723\u20131729","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2021120908252759700_R13","doi-asserted-by":"crossref","unstructured":"The International Committee for the Classification of the Late Stages of Retinopathy of Prematurity. 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