{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:35:23Z","timestamp":1756463723638,"version":"3.40.5"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p>We present the case of a 15-year-old boy with clinical features of an acute myocardial infarction. Angiography revealed a complete obstruction of the left main coronary artery. A coronary-aorto-bypass graft was undertaken immediately. Cardiac computed tomography demonstrated an anomalous origin of the left main coronary artery from the right coronary sinus of the aorta. A thrombophilic state with a heterozygote genotype for prothrombin G20210 mutation, a C677T methylenetetrahydrofolate reductase gene mutation, and a protein C type 1 deficiency was detected. No other embolic source could be identified. The patient recovered with persistent left ventricular dysfunction. He is now taking the anticoagulant warfarin. Combined prothrombotic defects in combination with additional risk factors such as coronary anomalies can lead to myocardial infarction even in children and adolescents.<\/jats:p>","DOI":"10.1542\/peds.2006-3181","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T17:53:25Z","timestamp":1185990805000},"page":"e424-e427","source":"Crossref","is-referenced-by-count":5,"title":["Myocardial Infarction in an Adolescent: Anomalous Origin of the Left Main Coronary Artery From the Right Coronary Sinus in Association With Combined Prothrombotic Defects"],"prefix":"10.1542","volume":"120","author":[{"given":"Martin","family":"Koestenberger","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Nagel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Gamillscheg","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Temmel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology, Department of Radiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Cvirn","sequence":"additional","affiliation":[{"name":"Institute of Physiological Chemistry, Center of Physiological Medicine, Medical University Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Beitzke","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2007,8,1]]},"reference":[{"key":"2021120901493825900_R1","doi-asserted-by":"crossref","unstructured":"Desai A, Patel S, Book W. \u201cMyocardial infarction\u201d in adolescents: do we have the correct diagnosis?Pediatr Cardiol.\u20082005;26:627\u2013631","DOI":"10.1007\/s00246-004-0864-5"},{"key":"2021120901493825900_R2","doi-asserted-by":"crossref","unstructured":"Schoebel F, Heintzen M, Jax W, et al. Acute myocardial infarction with origin of the left circumflex artery from the right (anterior) aortic sinus with retroaortic course to the left atrioventricular sulcus. Am J Cardiol.\u20081996;78:720\u2013721","DOI":"10.1016\/S0002-9149(96)00407-9"},{"key":"2021120901493825900_R3","doi-asserted-by":"crossref","unstructured":"Erbilen E, Ozhan H, Akdemir R, Yazici M. A case of myocardial infarction with sumatriptan use. Pediatr Cardiol.\u20082005;26:464\u2013466","DOI":"10.1007\/s00246-004-0768-4"},{"key":"2021120901493825900_R4","doi-asserted-by":"crossref","unstructured":"Gotsman I, Mosseri M. Acute myocardial infarction in a young woman with normal coronary arteries and a combined thrombophilia. Int J Cardiol.\u20082005;99:483\u2013484","DOI":"10.1016\/j.ijcard.2003.11.053"},{"key":"2021120901493825900_R5","doi-asserted-by":"crossref","unstructured":"Carano N, Agnetti A, Hagler D, Tchana B, Squarcia U, Bernarsconi S. 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