{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:12:27Z","timestamp":1761487947255,"version":"3.40.5"},"reference-count":55,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>OBJECTIVES. Precision grasping critically relies on the integrity of the corticospinal tract as evidenced in congenital hemiplegia by the correlation found between corticospinal dysgenesis and hand-movement deficits. Therefore, corticospinal dysgenesis could be used to anticipate upper-limb deficits in young infants with congenital hemiplegia. However, most studies have quantified corticospinal dysgenesis by measuring the cross-sectional area of cerebral peduncles on T1 MRI, a measure biased by other structures present in the peduncles. The purpose of this study was to evaluate the extent to which this may have hampered the conclusions of previous studies. We also aimed to investigate the relationship between upper-limb deficits and a more accurate measure of corticospinal dysgenesis to provide a tool for anticipating upper-limb deficits in infants with congenital hemiplegia.<\/jats:p>\n               <jats:p>METHODS. To address this issue, we measured corticospinal tract areas in 12 patients with congenital hemiplegia and 12 matched control subjects by using the diffusion tensor imaging technique. Corticospinal dysgenesis was quantified by computing a symmetry index between the area of the contralateral and ipsilateral corticospinal tracts. This value was then compared with that resulting from the conventional MRI method.<\/jats:p>\n               <jats:p>RESULTS. The symmetry indexes gathered with these 2 methods were highly correlated, although the diffusion tensor imaging symmetry indexes were significantly smaller. This indicates that, in patients with congenital hemiplegia, the conventional MRI measurement has led to a systematic underestimate of corticospinal dysgenesis. These 2 estimates of corticospinal dysgenesis were also correlated with upper-limb impairments and disabilities. Although the symmetry index computed from peduncle measurements was correlated solely with deficits in stereognosis, the diffusion tensor imaging index correlated with stereognosis, digital and manual dexterities, and ABILHAND-Kids, a measure of manual ability in daily life activities.<\/jats:p>\n               <jats:p>CONCLUSIONS. The diffusion tensor imaging symmetry index provides a useful prognostic tool for anticipating upper-limb deficits and their consequences in daily life activities.<\/jats:p>","DOI":"10.1542\/peds.2007-0394","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T02:07:40Z","timestamp":1195524460000},"page":"e1502-e1511","source":"Crossref","is-referenced-by-count":55,"title":["Corticospinal Dysgenesis and Upper-Limb Deficits in Congenital Hemiplegia: A Diffusion Tensor Imaging Study"],"prefix":"10.1542","volume":"120","author":[{"given":"Yannick","family":"Bleyenheuft","sequence":"first","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce\u0301cile B.","family":"Grandin","sequence":"additional","affiliation":[{"name":"Radiology Department"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Cosnard","sequence":"additional","affiliation":[{"name":"Radiology Department"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Olivier","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology, School of Medicine, Universite\u0301 Catholique de Louvain, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Thonnard","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2021120902002882900_R1","doi-asserted-by":"crossref","unstructured":"Galea MP, Darian-Smith I. 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