{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:00:14Z","timestamp":1792069214127,"version":"4.4.0"},"reference-count":43,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:p>OBJECTIVE. The goal was to estimate the population effect of 7-valent pneumococcal conjugate vaccine on rates of acute otitis media-related ambulatory visits and antibiotic prescriptions for &amp;lt;2-year-old children enrolled in private insurance plans.<\/jats:p>\n               <jats:p>METHODS. We performed a retrospective analysis of a defined population by using the 1997\u20132004 MarketScan databases, which included an average of &amp;gt;500000 person-years of observations for children &amp;lt;2 years of age. Trends in rates of International Classification of Diseases, Ninth Revision-coded ambulatory visits and antibiotic prescriptions attributable to acute otitis media were evaluated, and the national direct medical expenditures for these outcomes were estimated.<\/jats:p>\n               <jats:p>RESULTS. In a comparison of 2004 with 1997\u20131999 (baseline period), rates of ambulatory visits and antibiotic prescriptions attributable to acute otitis media decreased from 2173 to 1244 visits per 1000 person-years (42.7% reduction) and from 1244 to 722 prescriptions per 1000 person-years (41.9% reduction), respectively. Total, estimated, national direct medical expenditures for acute otitis media-related ambulatory visits and antibiotic prescriptions for children &amp;lt;2 years of age decreased from an average of $1.41 billion during 1997 to 1999 to $0.95 billion in 2004 (32.3% reduction).<\/jats:p>\n               <jats:p>CONCLUSIONS. Acute otitis media-related health care utilization and associated antibiotic prescriptions for privately insured young children decreased more than expected (on the basis of efficacy estimates in prelicensure clinical trials) after the introduction of routine 7-valent pneumococcal conjugate vaccine immunization. Although other factors, such as clinical practice guidelines to reduce antibiotic use, might have contributed to the observed trend, 7-valent pneumococcal conjugate vaccine may play an important role in reducing the burden of acute otitis media, resulting in substantial savings in medical care costs.<\/jats:p>","DOI":"10.1542\/peds.2007-0619","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T18:40:00Z","timestamp":1201891200000},"page":"253-260","source":"Crossref","is-referenced-by-count":232,"title":["Trends in Acute Otitis Media-Related Health Care Utilization by Privately Insured Young Children in the United States, 1997\u20132004"],"prefix":"10.1542","volume":"121","author":[{"given":"Fangjun","family":"Zhou","sequence":"first","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Shefer","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Kong","sequence":"additional","affiliation":[{"name":"Science Applications International, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Pekka","family":"Nuorti","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"2021120820170033300_R1","doi-asserted-by":"crossref","unstructured":"Klein JO. The burden of otitis media. Vaccine.\u20082000;19(suppl 1):S2\u2013S8","DOI":"10.1016\/S0264-410X(00)00271-1"},{"key":"2021120820170033300_R2","doi-asserted-by":"crossref","unstructured":"Bluestone CD, Stephenson JS, Martin LM. Ten-year review of otitis media pathogens. Pediatr Infect Dis J.\u20081992;11(8 suppl):S7\u2013S11","DOI":"10.1097\/00006454-199208001-00002"},{"key":"2021120820170033300_R3","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Subcommittee on Management of Acute Otitis Media. Diagnosis and management of acute otitis media. 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