{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:36:33Z","timestamp":1770338193906,"version":"3.49.0"},"reference-count":40,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:p>OBJECTIVE. Childhood sleep-disordered breathing has an adverse impact on cognitive development, behavior, quality of life, and use of health care resources. Early viral infections and other immune-mediated responses may contribute to development of the chronic inflammation of the upper airway and hypertrophic upper airway lymphadenoid tissues underlying childhood sleep-disordered breathing. Breastfeeding provides immunologic protection against such early exposures. Therefore, we sought to explore whether sleep-disordered breathing severity would differ for children who were breastfed as infants.<\/jats:p>\n               <jats:p>METHODS. The parents or guardians of 196 habitually snoring children (mean \u00b1 SD: 6.7 \u00b1 2.9 years old) who were undergoing overnight polysomnography at Kosair Children's Hospital Sleep Medicine and Apnea Center completed a retrospective survey on the method(s) used to feed the child as an infant.<\/jats:p>\n               <jats:p>RESULTS. Among habitually snoring children, those who were fed breast milk for at least 2 months had significantly reduced sleep-disordered breathing severity on every measure assessed, including apnea-hypopnea index, oxyhemoglobin desaturation nadir, and respiratory arousal index. Breastfeeding for longer than 5 months did not contribute additional benefits.<\/jats:p>\n               <jats:p>CONCLUSIONS. Our findings support the notion that breastfeeding may provide long-term protection against the severity of childhood sleep-disordered breathing. Future research should explore mechanism(s) whereby infant-feeding methods may affect the pathophysiology of development of childhood sleep-disordered breathing.<\/jats:p>","DOI":"10.1542\/peds.2007-0722","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T17:08:45Z","timestamp":1193936925000},"page":"1030-1035","source":"Crossref","is-referenced-by-count":54,"title":["Infant-Feeding Methods and Childhood Sleep-Disordered Breathing"],"prefix":"10.1542","volume":"120","author":[{"given":"Hawley Evelyn","family":"Montgomery-Downs","sequence":"first","affiliation":[{"name":"Department of Psychology, West Virginia University, Morgantown, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie McLaughlin","family":"Crabtree","sequence":"additional","affiliation":[{"name":"Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar Sans","family":"Capdevila","sequence":"additional","affiliation":[{"name":"Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"2022051612183275100_R1","doi-asserted-by":"crossref","unstructured":"Brouilette R, Hanson D, Davis R, et al. A diagnostic approach to suspected obstructive sleep apnea in children. J Pediatr.\u20081984;105:10\u201314","DOI":"10.1016\/S0022-3476(84)80348-0"},{"key":"2022051612183275100_R2","doi-asserted-by":"crossref","unstructured":"Gislason T, Benediktsdottir B. Snoring, apneic episodes, and nocturnal hypoxemia among children 6 months to 6 years old: an epidemiologic study of lower limit of prevalence. Chest.\u20081995;107:963\u2013966","DOI":"10.1378\/chest.107.4.963"},{"key":"2022051612183275100_R3","doi-asserted-by":"crossref","unstructured":"Reuveni H, Simon T, Tal A, Elhayany A, Tarasiuk A. Health care services utilization in children with obstructive sleep apnea syndrome. Pediatrics.\u20082002;110:68\u201372","DOI":"10.1542\/peds.110.1.68"},{"key":"2022051612183275100_R4","doi-asserted-by":"crossref","unstructured":"Rona JR, Li L, Gulliford MC, Chinn S. Disturbed sleep: effects of sociocultural factors and illness. Arch Dis Child.\u20081998;78:20\u201325","DOI":"10.1136\/adc.78.1.20"},{"key":"2022051612183275100_R5","doi-asserted-by":"crossref","unstructured":"Archbold KH, Pituch KJ, Panahi P, Chervin RD. Symptoms of sleep disturbances among children at two general pediatrics clinics. J Pediatr.\u20082002;140:97\u2013102","DOI":"10.1067\/mpd.2002.119990"},{"key":"2022051612183275100_R6","doi-asserted-by":"crossref","unstructured":"Marcus CL, Gozal D, Arens R, et al. Ventilatory responses during wakefulness in children with obstructive sleep apnea. Am J Respir Crit Care Med.\u20081994;149:715\u2013721","DOI":"10.1164\/ajrccm.149.3.8118641"},{"key":"2022051612183275100_R7","doi-asserted-by":"crossref","unstructured":"Amin RS, Kimball TR, Bean JA, et al. Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea. Am J Respir Crit Care Med.\u20082002;165:1395\u20131399","DOI":"10.1164\/rccm.2105118"},{"key":"2022051612183275100_R8","doi-asserted-by":"crossref","unstructured":"Amin RS, Kimball TR, Kalra M, et al. Left ventricular function in children with sleep-disordered breathing. Am J Cardiol.\u20082005;95:801\u2013804","DOI":"10.1016\/j.amjcard.2004.11.044"},{"key":"2022051612183275100_R9","doi-asserted-by":"crossref","unstructured":"Schechter MS; American Academy of Pediatrics, Section on Pediatric Pulmonology, Subcommittee on Obstructive Sleep Apnea Syndrome. Technical report: diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics.\u20082002;109(4). Available at: www.pediatrics.org\/cgi\/content\/full\/109\/4\/e69","DOI":"10.1542\/peds.109.4.e69"},{"key":"2022051612183275100_R10","doi-asserted-by":"crossref","unstructured":"Beebe DW. Neurobehavioral morbidity associated with disordered breathing during sleep in children: a comprehensive review. 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Pediatr Res.\u20082002;52:449\u2013453","DOI":"10.1203\/00006450-200209000-00024"},{"key":"2022051612183275100_R14","doi-asserted-by":"crossref","unstructured":"Kheirandish L, Gozal D, Pequignot JM, Pequignot J, Row BW. Intermittent hypoxia during development induces long-term alterations in spatial working memory, monoamines, and dendritic branching in rat frontal cortex. Pediatr Res.\u20082005;58:594\u2013599","DOI":"10.1203\/01.pdr.0000176915.19287.e2"},{"key":"2022051612183275100_R15","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Section on Pediatric Pulmonology, Subcommittee on Obstructive Sleep Apnea Syndrome. Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics.\u20082002;109:704\u2013712","DOI":"10.1542\/peds.109.4.704"},{"key":"2022051612183275100_R16","doi-asserted-by":"crossref","unstructured":"Carroll JL, McColley SA, Marcus CL, Curtis S, Loughlin GM. 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Am J Respir Crit Care Med.\u20082001;163:S7\u2013S9","DOI":"10.1164\/ajrccm.163.supplement_1.2011110"},{"key":"2022051612183275100_R23","doi-asserted-by":"crossref","unstructured":"Piedimonte G. Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr Infect Dis J.\u20082003;22:S66\u2013S75","DOI":"10.1097\/01.inf.0000053888.67311.1d"},{"key":"2022051612183275100_R24","doi-asserted-by":"crossref","unstructured":"Kimpen JLL, Simoes EAF. Respiratory syncytial virus and reactive airway disease; new developments prompt a new review. Am J Respir Crit Care Med.\u20082001;163(3 pt 2):S1","DOI":"10.1164\/ajrccm.163.supplement_1.2011109"},{"key":"2022051612183275100_R25","doi-asserted-by":"crossref","unstructured":"Ogra PL. Respiratory syncytial virus: the virus, the disease and the immune response. Paediatr Respir Rev.\u20082004;5(suppl A):S119\u2013S126","DOI":"10.1016\/S1526-0542(04)90023-1"},{"key":"2022051612183275100_R26","doi-asserted-by":"crossref","unstructured":"Bronzetti E, Artico M, Pompili E, et al. Neurotrophins and neurotransmitters in human palatine tonsils: an immunohistochemical and RT-PCR analysis. Int J Mol Med.\u20082006;18:49\u201358","DOI":"10.3892\/ijmm.18.1.49"},{"key":"2022051612183275100_R27","doi-asserted-by":"crossref","unstructured":"Goldbart AD, Mager E, Veling MC, et al. Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Pediatr Res.\u20082007; In press","DOI":"10.1203\/PDR.0b013e31814257ed"},{"key":"2022051612183275100_R28","doi-asserted-by":"crossref","unstructured":"Goldbart AD, Goldman JL, Veling MC, Gozal D. Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med.\u20082005;172:364\u2013370","DOI":"10.1164\/rccm.200408-1064OC"},{"key":"2022051612183275100_R29","doi-asserted-by":"crossref","unstructured":"Tsutsumi H, Honjo T, Nagai K, Chiba Y, Chiba S, Tsugawa S. Immunoglobulin A antibody response to respiratory syncytial virus structural proteins in colostrum and milk. J Clin Microbiol.\u20081989;27:1949\u20131951","DOI":"10.1128\/jcm.27.9.1949-1951.1989"},{"key":"2022051612183275100_R30","doi-asserted-by":"crossref","unstructured":"Hanson LA, Korotkova M, Telemo E. Breast-feeding, infant formulas, and the immune system. Ann Allergy Asthma Immunol.\u20082003;90(suppl 3):59\u201363","DOI":"10.1016\/S1081-1206(10)61662-6"},{"key":"2022051612183275100_R31","doi-asserted-by":"crossref","unstructured":"Schwartz R. Respiratory syncytial virus in infants and children. 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