{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:15:21Z","timestamp":1789503321959,"version":"build-2803163510"},"reference-count":29,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>OBJECTIVE. The objective of this study was to determine gender differences in pediatric patients with Crohn disease.<\/jats:p>\n               <jats:p>METHODS. We conducted a retrospective cohort study of 989 consecutive pediatric patients (566 boys, 423 girls) who had Crohn disease (aged 0 to 17 years at diagnosis) by using the Pediatric IBD Consortium Registry. Uniform data were analyzed to compare the presentation and course of disease according to gender.<\/jats:p>\n               <jats:p>RESULTS. Median follow-up time was 2.8 years. Mean \u00b1 SD age at diagnosis of inflammatory bowel disease (11.5 \u00b1 3.8 years) did not differ by gender. Compared with boys, girls had a higher prevalence of mouth sores at symptom onset and a higher prevalence of hypoalbuminemia at the time of diagnosis. Location of disease did not differ by gender. A higher proportion of girls had abnormal anti\u2013outer membrane porin of Escherichia coli levels compared with boys. Girls were at increased risk for erythema nodosum\/pyoderma gangrenosum and decreased risk for growth failure compared with boys.<\/jats:p>\n               <jats:p>CONCLUSIONS. Girls appear to have an overall more severe course of disease; however, boys are at increased risk for developing growth failure. Disease course and the impact of disease severity on growth according to gender in pediatric Crohn disease require prospective study.<\/jats:p>","DOI":"10.1542\/peds.2007-0905","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T17:33:39Z","timestamp":1196444019000},"page":"e1418-e1425","source":"Crossref","is-referenced-by-count":97,"title":["Gender Differences in Presentation and Course of Disease in Pediatric Patients With Crohn Disease"],"prefix":"10.1542","volume":"120","author":[{"given":"Neera","family":"Gupta","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Bostrom","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Ferry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harland S.","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Baldassano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children's Center for Digestive Healthcare, Children's Healthcare of Atlanta, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Abramson","sequence":"additional","affiliation":[{"name":"Kaiser Permanente of Northern California, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children's Center for Digestive Healthcare, Children's Healthcare of Atlanta, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin B.","family":"Heyman","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2021120901582178100_R1","doi-asserted-by":"crossref","unstructured":"Vind I, Riis L, Jess T, Knudsen E, et al. 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