{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:39:20Z","timestamp":1783276760913,"version":"3.54.6"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:p>OBJECTIVE. The goal was to establish whether reduced amounts of pulmonary surfactant contribute to postextubation respiratory failure in preterm infants recovering from respiratory distress syndrome.<\/jats:p><jats:p>METHODS. We prospectively recruited preterm infants who needed mechanical ventilation and exogenous surfactant for treatment of moderate\/severe respiratory distress syndrome and could not be extubated before day 3 of life. 13C-labeled dipalmitoyl-phosphatidylcholine was administered endotracheally as tracer before extubation, for estimation of surfactant disaturated phosphatidylcholine pool size and half-life. Patients were retrospectively divided into 3 groups, that is, extubation failure if, after extubation, they needed reintubation or continuous positive airway pressure treatment of \u22656 cmH2O and fraction of inspired oxygen of &amp;gt;0.4, extubation success if they did not meet the failure criteria, and not extubated if they needed ongoing ventilation. Clinical and respiratory parameters were recorded hourly.<\/jats:p><jats:p>RESULTS. Reliable kinetic data could be obtained for 63 of the 88 enrolled neonates. Sixteen, 23, and 24 neonates were categorized in the extubation failure, extubation success, and not extubated groups, respectively. Clinical and demographic characteristics did not differ between the extubation failure and extubation success groups. Disaturated phosphatidylcholine pool size was smaller in the extubation failure group than in the extubation success group (25 \u00b1 12 vs 43 \u00b1 24 mg\/kg) and was 37 \u00b1 32 mg\/kg in the not extubated group. Disaturated phosphatidylcholine half-life was 19 \u00b1 7, 24 \u00b1 12, and 28 \u00b1 18 hours in the extubation failure, extubation success, and not extubated groups, respectively.<\/jats:p><jats:p>CONCLUSIONS. In a selected population of preterm infants with moderate\/severe respiratory distress syndrome who could not be extubated in the first 3 days of life, infants who were reintubated or needed high continuous positive airway pressure settings after extubation had a smaller disaturated phosphatidylcholine pool size than did those who were successfully extubated or needed low continuous positive airway pressure settings.<\/jats:p>","DOI":"10.1542\/peds.2007-1021","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T13:29:15Z","timestamp":1214918955000},"page":"102-108","source":"Crossref","is-referenced-by-count":23,"title":["Surfactant Status in Preterm Neonates Recovering From Respiratory Distress Syndrome"],"prefix":"10.1542","volume":"122","author":[{"given":"Giovanna","family":"Verlato","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Elisa","family":"Cogo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Balzani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Gucciardi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Burattini","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Institute of Maternal-Infantile Sciences, Polytechnic University of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"De Benedictis","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Salesi Children Hospital, University of Ancona, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Martiri","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Institute of Maternal-Infantile Sciences, Polytechnic University of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilio Paolo","family":"Carnielli","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Institute of Maternal-Infantile Sciences, Polytechnic University of Marche, Ancona, Italy"},{"name":"Division of Pediatrics, Salesi Children Hospital, University of Ancona, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"2021120905554517500_R1","doi-asserted-by":"crossref","unstructured":"Martin RJ, Walsh-Sukys MC. 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