{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:08:04Z","timestamp":1786554484568,"version":"build-2736575974"},"reference-count":35,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p>OBJECTIVE. The purpose of this work was to analyze outcome with focus on growth in infants fetally exposed to heart block-associated maternal anti-Ro52\/SSA autoantibodies and identify maternal factors other than the autoantibodies increasing the risk of fetal heart block.<\/jats:p>\n               <jats:p>PATIENTS AND METHODS. Thirty-two pregnancies in 30 anti-Ro52-positive mothers were included. Seven fetuses developed second-degree or third-degree atrioventricular block, 8 developed first-degree atrioventricular block, and 17 had normal atrioventricular conduction, as diagnosed by using Doppler echocardiography. Three of 6 surviving fetuses with second-degree or third-degree atrioventricular block received treatment with fluorinated steroids. Two fetuses with second-degree atrioventricular block converted to first-degree atrioventricular block without any signs of progression during the study period. Maternal and longitudinal infant data were collected from planned neonatal follow-up and childhood health records from birth to 12 months of age in 31 survivors.<\/jats:p>\n               <jats:p>RESULTS. Women giving birth to infants with prenatal second-degree or third-degree atrioventricular block were older and with higher parity than those with first-degree atrioventricular block or normal atrioventricular conduction. Second-degree or third-degree atrioventricular block pregnancies were &amp;lt;40 completed weeks, whereas pregnancies with first-degree atrioventricular block or normal atrioventricular conduction had a normal duration. Fetuses with second-degree or third-degree atrioventricular block were retarded by \u22120.98 \u00b1 0.77 SD in weight at birth and did not show any catch-up during infancy. In contrast, fetuses with first-degree atrioventricular block or normal atrioventricular conduction had a weight reduction of \u22120.51 \u00b1 1.01 SD with a catch-up during the first months after birth.<\/jats:p>\n               <jats:p>CONCLUSIONS. This report documents that newborns with autoantibody-mediated second-degree or third-degree atrioventricular block are retarded in growth, with no catch-up during infancy, whereas fetuses with first-degree atrioventricular block or normal atrioventricular conduction have a normal growth soon after birth. Increased maternal age and\/or parity seem to carry an increased risk for fetal heart block.<\/jats:p>","DOI":"10.1542\/peds.2007-1659","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T20:25:58Z","timestamp":1207081558000},"page":"e803-e809","source":"Crossref","is-referenced-by-count":35,"title":["Outcome and Growth of Infants Fetally Exposed to Heart Block-Associated Maternal Anti-Ro52\/SSA Autoantibodies"],"prefix":"10.1542","volume":"121","author":[{"given":"Amanda","family":"Skog","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Wahren-Herlenius","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Sundstro\u0308m","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Bremme","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven-Erik","family":"Sonesson","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2021120902101192900_R1","doi-asserted-by":"crossref","unstructured":"Skomsvoll JF, Ostensen M, Irgens LM, Baste V. 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