{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:15:23Z","timestamp":1773274523137,"version":"3.50.1"},"reference-count":39,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:p>OBJECTIVE. Establishing enteral feeding is an important goal in the care of very low birth weight infants. In such infants, receipt of \u226550 mL\/kg per day human milk during hospitalization has been associated with shorter time to full enteral feeding. The objective of this study was to determine whether high proportions (\u226550%) of human milk during feeding advancement are associated with shorter time to full enteral feeding and improved feeding tolerance.<\/jats:p><jats:p>METHODS. This was a prospective cohort study of very low birth weight infants (n = 127) who were grouped into low (&amp;lt;50%; n = 34) and high (\u226550%; n = 93) human milk consumption groups according to their human milk proportion of enteral feeding during the time of feeding advancement. The primary outcomes of interest were ages at which 100 and 150 mL\/kg per day enteral feedings were achieved.<\/jats:p><jats:p>RESULTS. The high human milk group reached 100 mL\/kg per day enteral feeding 4.5 days faster than the low human milk group. The high human milk group reached 150 mL\/kg per day enteral feeding 5 days faster than the low human milk group. After adjustment for gestational age, gender, and respiratory distress syndrome, times to reach 100 and 150 mL\/kg per day were significantly shorter for those in the high human milk group. Infants in the high human milk group had a greater number of stools per day; other indicators of feeding tolerance were not statistically different.<\/jats:p><jats:p>CONCLUSION. In infants who weighed \u22641250 g, enteral feeding that contained at least 50% maternal human milk was associated with fewer days to full enteral feedings.<\/jats:p>","DOI":"10.1542\/peds.2007-2110","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T14:15:50Z","timestamp":1212416150000},"page":"e1528-e1533","source":"Crossref","is-referenced-by-count":50,"title":["Human Milk Consumption and Full Enteral Feeding Among Infants Who Weigh \u22641250 Grams"],"prefix":"10.1542","volume":"121","author":[{"given":"Paula M.","family":"Sisk","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl A.","family":"Lovelady","sequence":"additional","affiliation":[{"name":"Department of Nutrition"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Gruber","sequence":"additional","affiliation":[{"name":"School of Environmental Science, University of North Carolina, Greensboro, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Dillard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Michael","family":"O'Shea","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"2021120905440035500_R1","doi-asserted-by":"crossref","unstructured":"Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD neonatal research network. Pediatrics.\u20082002;110(2 pt 1):285\u2013291","DOI":"10.1542\/peds.110.2.285"},{"key":"2021120905440035500_R2","doi-asserted-by":"crossref","unstructured":"Flidel-Rimon O, Friedman S, Juster-Reicher A, Amitay M, Shinwell E. Early enteral feeding and nosocomial sepsis in very low birth weight infants. 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Pediatrics.\u20081999;103(2):434\u2013439","DOI":"10.1542\/peds.103.2.434"},{"key":"2021120905440035500_R6","doi-asserted-by":"crossref","unstructured":"Dusick AM, Poindexter BB, Ehrenkrantz RA, Lemons JA. Growth failure in the preterm infant: can we catch up?Semin Perinatol.\u20082003;27(4):302\u2013310","DOI":"10.1016\/S0146-0005(03)00044-2"},{"key":"2021120905440035500_R7","unstructured":"Rohana J, Hasmawati J, Zulkifli SZ. Risk factors associated with low bone mineral content in very low birth weight infants. Singapore Med J.\u20082007;48(3):191\u2013194"},{"key":"2021120905440035500_R8","doi-asserted-by":"crossref","unstructured":"Bisset WM, Watt JB, Rivers RP, Milla PJ. Ontogeny of fasting small intestinal motor activity in the human infant. Gut.\u20081988;29(4):483\u2013488","DOI":"10.1136\/gut.29.4.483"},{"key":"2021120905440035500_R9","doi-asserted-by":"crossref","unstructured":"Berseth CL. 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