{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:14:19Z","timestamp":1760908459696,"version":"3.40.5"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:p>OBJECTIVES. The objectives of this study were to evaluate the contribution of erythroid apoptosis to neonatal idiopathic pathologic jaundice and to determine whether a measurement of the erythroid apoptosis value at birth could predict the development of hyperbilirubinemia during the first 15 days of life.<\/jats:p>\n               <jats:p>PATIENTS AND METHODS. Three groups were defined: group 1 (n = 101), healthy newborns whose erythroid apoptosis value and serum total bilirubin levels were detected from birth to day 15; group 2 (n = 24), newborns who were hospitalized for jaundice (serum total bilirubin level: &amp;gt;12.9 mg\/dL) without any identifiable pathologic cause; and group 3 (control group, n = 24), healthy newborns whose serum total bilirubin levels were \u226412.9 mg\/dL. Erythroid apoptosis value was assessed by flow cytometry using an annexin-V fluorescein isothiocyanate kit.<\/jats:p>\n               <jats:p>RESULTS. In group 1, there was no correlation between the erythroid apoptosis value and serum total bilirubin levels obtained at birth and at the fourth and 15th days of life; the erythrocyte apoptosis value obtained at birth was not significantly different between the neonates whose serum total bilirubin levels were &amp;gt;12.9 and \u226412.9 mg\/dL and who had prolonged and nonprolonged jaundice during follow-up. The erythroid apoptosis value differed significantly between the newborns in groups 2 and 3. There was no significant correlation between the erythroid apoptosis value and serum total bilirubin levels of the infants in groups 2 and 3.<\/jats:p>\n               <jats:p>CONCLUSIONS. The erythroid apoptosis value obtained at birth could not predict the development of hyperbilirubinemia in neonates, but it was increased significantly in jaundiced neonates whose serum total bilirubin levels were &amp;gt;12.9 mg\/dL. In these infants, increase in the erythroid apoptosis value may be a result of the toxic effect of bilirubin or of a protective mechanism of neonates to increase heme turnover and bilirubin production to diminish oxidative stress.<\/jats:p>","DOI":"10.1542\/peds.2007-2215","type":"journal-article","created":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T00:25:00Z","timestamp":1208823900000},"page":"e1348-e1351","source":"Crossref","is-referenced-by-count":4,"title":["Erythroid Apoptosis in Idiopathic Neonatal Jaundice"],"prefix":"10.1542","volume":"121","author":[{"given":"Hasan","family":"O\u0308zkan","sequence":"first","affiliation":[{"name":"Departments of Pediatric Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hale","family":"O\u0308ren","sequence":"additional","affiliation":[{"name":"Pediatric Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansur","family":"Tatl\u0131","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Ates\u0327","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Dokuz Eylu\u0308l University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Kumral","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Duman","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"2021120908263280800_R1","doi-asserted-by":"crossref","unstructured":"Newman TB, Easterling MJ, Goldman ES, Stevenson DK. 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