{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:55:14Z","timestamp":1774677314641,"version":"3.50.1"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:p>OBJECTIVE. We recently reported that 60% of children newly diagnosed with cystic fibrosis who had pancreatic insufficiency responded to treatment initiation and achieved catch-up weight gain to a level comparable with their birth weight z score within 2 years of diagnosis (\u201cresponders\u201d), whereas the remaining 40% failed to do so (\u201cnonresponders\u201d). The present study examined the impact of this early weight recovery on subsequent growth pattern and pulmonary status at 6 years of age.<\/jats:p><jats:p>PATIENTS AND METHODS. Sixty-three children with cystic fibrosis who had pancreatic insufficiency but no meconium ileus, and were enrolled in the Wisconsin Cystic Fibrosis Neonatal Screening Project, were studied. Responders were defined by a recovery of weight z score comparable with that at birth within 2 years of diagnosis. From ages 2 to 6, growth was measured by both height and BMI. Pulmonary status was evaluated by symptoms, spirometry, quantitative chest radiography, and respiratory microbiology.<\/jats:p><jats:p>RESULTS. The majority (71%) of the responders maintained their early weight recovery through 6 years of age, whereas only 32% of the nonresponders achieved substantial growth improvement from 2 to 6 years of age. Proportionately fewer responders reported cough symptoms (10% daytime cough; 22% nighttime cough) compared with nonresponders (41% daytime cough; 45% nighttime cough) at age 6. The percentage of predicted forced expiratory volume in 1 second at age 6 was 11% higher in responders (99.5% \u00b1 13.9%) compared with nonresponders (88.3% \u00b1 18.5%). Responders had significantly better Brasfield (20.1 \u00b1 1.4) and Wisconsin chest radiograph (8.3 \u00b1 3.3) scores compared with nonresponders (Brasfield: 18.9 \u00b1 1.8; Wisconsin: 12.3 \u00b1 8.3). Respiratory microbiology results were not significantly different. Multiple regression analyses indicated that the positive association between responder and percent predicted forced expiratory volume in 1 second at 6 years of age remained statistically significant after controlling for infections with Pseudomonas aeruginosa and Staphylococcus aureus and chest radiograph scores. Growth patterns from 2 to 6 years of age were not associated with pulmonary measures at age 6.<\/jats:p><jats:p>CONCLUSIONS. Patients with cystic fibrosis with pancreatic insufficiency who achieved early growth recovery within 2 years of diagnosis had fewer cough symptoms, higher lung function, and better chest radiograph scores at 6 years of age.<\/jats:p>","DOI":"10.1542\/peds.2007-3089","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T12:23:44Z","timestamp":1232972624000},"page":"714-722","source":"Crossref","is-referenced-by-count":95,"title":["Recovery of Birth Weight<i>z<\/i>Score Within 2 Years of Diagnosis Is Positively Associated With Pulmonary Status at 6 Years of Age in Children With Cystic Fibrosis"],"prefix":"10.1542","volume":"123","author":[{"given":"HuiChuan J.","family":"Lai","sequence":"first","affiliation":[{"name":"Departments of Nutritional Sciences"},{"name":"Biostatistics and Medical Informatics"},{"name":"Pediatrics, University of Wisconsin, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Shoff","sequence":"additional","affiliation":[{"name":"Departments of Nutritional Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Farrell","sequence":"additional","affiliation":[{"name":"Pediatrics, University of Wisconsin, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"with the Wisconsin Cystic Fibrosis Neonatal Screening Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"2021120822591118300_R1","doi-asserted-by":"crossref","unstructured":"Kraemer R, Rudeberg A, Hadorn B, Rossie E. 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