{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:28:02Z","timestamp":1792481282059,"version":"4.5.0"},"reference-count":57,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:p>OBJECTIVE. Our objective was to demonstrate correlations between invasive pneumococcal disease in children and circulating respiratory viruses.<\/jats:p>\n               <jats:p>METHODS. This retrospective study included 6 winter respiratory viral seasons (2001\u20132007) in Intermountain Healthcare, an integrated health system in the Intermountain West, including Primary Children's Medical Center in Salt Lake City, Utah. Children &amp;lt;18 years of age who were hospitalized with either invasive pneumococcal disease in any Intermountain Healthcare facility or culture-confirmed invasive pneumococcal disease at Primary Children's Medical Center were included. We analyzed the correlation between invasive pneumococcal disease and circulating respiratory viruses.<\/jats:p>\n               <jats:p>RESULTS. A total of 435 children with invasive pneumococcal disease and 203 with culture-confirmed invasive pneumococcal disease were hospitalized in an Intermountain Healthcare facility or Primary Children's Medical Center during the study period. During the same period, 6963 children with respiratory syncytial virus, 1860 with influenza virus, 1459 with parainfluenza virus, and 818 with adenoviruses were evaluated at Primary Children's Medical Center. A total of 253 children with human metapneumovirus were identified during the last 5 months of the study. There were correlations between invasive pneumococcal disease and seasonal respiratory syncytial virus, influenza virus, and human metapneumovirus activity. The correlation with invasive pneumococcal disease was strong up to 4 weeks after respiratory syncytial virus activity. For influenza virus and human metapneumovirus, the correlations were strong at 2 weeks after activity of these viruses. Pneumonia was the most common clinical disease associated with culture-confirmed invasive pneumococcal disease, mostly attributable to serotypes 1, 19A, 3, and 7F.<\/jats:p>\n               <jats:p>CONCLUSIONS. In the post\u2013pneumococcal conjugate vaccine era, seasonal increases in respiratory syncytial virus, influenza virus, and human metapneumovirus infections in children were associated with increased pediatric admissions with invasive pneumococcal disease, especially pneumonia caused by nonvaccine serotypes.<\/jats:p>","DOI":"10.1542\/peds.2007-3192","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T13:38:30Z","timestamp":1217597910000},"page":"229-237","source":"Crossref","is-referenced-by-count":152,"title":["Seasonal Invasive Pneumococcal Disease in Children: Role of Preceding Respiratory Viral Infection"],"prefix":"10.1542","volume":"122","author":[{"given":"Krow","family":"Ampofo","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bender","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Korgenski","sequence":"additional","affiliation":[{"name":"Primary Children's Medical Center, Intermountain Health Care, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Daly","sequence":"additional","affiliation":[{"name":"Primary Children's Medical Center, Intermountain Health Care, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Pavia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie L.","family":"Byington","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"2021120906002684400_R1","doi-asserted-by":"crossref","unstructured":"Leimkugel J, Forgor A, Gagneux S, et al. An outbreak of serotype 1 Streptococcus pneumoniae meningitis in Northern Ghana with features that are characteristic of Neisseria meningitides meningitis epidemics. J Infect Dis.\u20082005;192(2):192\u2013199","DOI":"10.1086\/431151"},{"key":"2021120906002684400_R2","doi-asserted-by":"crossref","unstructured":"Hogg G, Strachan J. Pneumococcal infections in Victoria, Australia. Vaccine.\u20081999;17(suppl 1):S119\u2013S121","DOI":"10.1016\/S0264-410X(99)00120-6"},{"key":"2021120906002684400_R3","doi-asserted-by":"crossref","unstructured":"Jette\u0301 L, Lamothe F. Surveillance of invasive Streptococcus pneumoniae infection in Quebec, Canada, from 1984 to 1986: serotype distribution, antimicrobial susceptibility, and clinical characteristics. J Clin Microbiol.\u20081989;27(1):1\u20135","DOI":"10.1128\/jcm.27.1.1-5.1989"},{"key":"2021120906002684400_R4","doi-asserted-by":"crossref","unstructured":"Kertesz DA, Di Fabio JL, de Cunto Brandileone MC, et al. Invasive Streptococcus pneumoniae infection in Latin American children: results of the Pan American Health Organization Surveillance Study. Clin Infect Dis.\u20081998;26(6):1355\u20131361","DOI":"10.1086\/516350"},{"key":"2021120906002684400_R5","doi-asserted-by":"crossref","unstructured":"Byington CL, Spencer LY, Johnson TA, et al. An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations. Clin Infect Dis.\u20082002;34(4):434\u2013440","DOI":"10.1086\/338460"},{"key":"2021120906002684400_R6","doi-asserted-by":"crossref","unstructured":"Kim P, Musher D, Glezen P, et al. Association of invasive pneumococcal disease with season, atmospheric conditions, air pollution, and the isolation of respiratory viruses. Clin Infect Dis.\u20081996;22(1):100\u2013106","DOI":"10.1093\/clinids\/22.1.100"},{"key":"2021120906002684400_R7","doi-asserted-by":"crossref","unstructured":"Watson M, Gilmour R, Menzies R, et al. The association of respiratory viruses, temperature, and other climatic parameters with the incidence of invasive pneumococcal disease in Sydney, Australia. Clin Infect Dis.\u20082006;42(2):211\u2013215","DOI":"10.1086\/498897"},{"key":"2021120906002684400_R8","doi-asserted-by":"crossref","unstructured":"O'Brien K, Walters M, Sellman J, et al. Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection. Clin Infect Dis.\u20082000;30(5):784\u2013789","DOI":"10.1086\/313772"},{"key":"2021120906002684400_R9","doi-asserted-by":"crossref","unstructured":"Dowell S, Whitney C, Wright C, et al. Seasonal patterns of invasive pneumococcal disease. Emerg Infect Dis.\u20082003;9(5):573\u2013579","DOI":"10.3201\/eid0905.020556"},{"key":"2021120906002684400_R10","doi-asserted-by":"crossref","unstructured":"Sullivan KM, Monto AS, Longini IM Jr. Estimates of the US health impact of influenza. Am J Public Health.\u20081993;83(12):1712\u20131716","DOI":"10.2105\/AJPH.83.12.1712"},{"key":"2021120906002684400_R11","doi-asserted-by":"crossref","unstructured":"Parrott RH, Kim HW, Arrobio JO, et al. Epidemiology of respiratory syncytial virus infection in Washington, D.C., part II: infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol.\u20081973;98(4):289\u2013300","DOI":"10.1093\/oxfordjournals.aje.a121558"},{"key":"2021120906002684400_R12","doi-asserted-by":"crossref","unstructured":"Talbot T, Poehling K, Hartert T, et al. Seasonality of invasive pneumococcal disease: temporal relation to documented influenza and respiratory syncytial viral circulation. Am J Med.\u20082005;118(3):285\u2013291","DOI":"10.1016\/j.amjmed.2004.09.016"},{"key":"2021120906002684400_R13","doi-asserted-by":"crossref","unstructured":"Haddy R, Perry K, Chacko C, et al. 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Changing characteristics of invasive pneumococcal disease in Metropolitan Atlanta, Georgia, after introduction of a 7-valent pneumococcal conjugate vaccine. Clin Infect Dis.\u20082007;44(12):1569\u20131576","DOI":"10.1086\/518149"},{"key":"2021120906002684400_R38","unstructured":"Centers for Disease Control and Prevention. Emergence of antimicrobial-resistant serotype 19A Streptococcus pneumoniae: Massachusetts, 2001\u20132006. MMWR Morb Mortal Wkly Rep.\u20082007;56(41):1077\u20131080"},{"key":"2021120906002684400_R39","doi-asserted-by":"crossref","unstructured":"Saadi AT, Blackwell CC, Raza MW, et al. Factors enhancing adherence of toxigenic Staphylococcus aureus to epithelial cells and their possible role in sudden infant death syndrome. Epidemiol Infect.\u20081993;110(3):507\u2013517","DOI":"10.1017\/S0950268800050937"},{"key":"2021120906002684400_R40","doi-asserted-by":"crossref","unstructured":"Ha\u030akansson A, Kidd A, Wadell G, et al. Adenovirus infection enhances in vitro adherence of Streptococcus pneumoniae. Infect Immun.\u20081994;62(7):2707\u20132714","DOI":"10.1128\/iai.62.7.2707-2714.1994"},{"key":"2021120906002684400_R41","doi-asserted-by":"crossref","unstructured":"McCullers JA. Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev.\u20082006;19(3):571\u2013582","DOI":"10.1128\/CMR.00058-05"},{"key":"2021120906002684400_R42","doi-asserted-by":"crossref","unstructured":"Hament JM, Aerts PC, Fleer A, et al. Direct binding of respiratory syncytial virus to pneumococci: a phenomenon that enhances both pneumococcal adherence to human epithelial cells and pneumococcal invasiveness in a murine model. Pediatr Res.\u20082005;58(6):1198\u20131203","DOI":"10.1203\/01.pdr.0000188699.55279.1b"},{"key":"2021120906002684400_R43","doi-asserted-by":"crossref","unstructured":"Thorburn K, Harigopal S, Reddy V, et al. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax.\u20082006;61(7):611\u2013615","DOI":"10.1136\/thx.2005.048397"},{"key":"2021120906002684400_R44","doi-asserted-by":"crossref","unstructured":"Peltola V, Murti K, McCullers J. Influenza virus neuraminidase contributes to secondary bacterial pneumonia. J Infect Dis.\u20082005;192(2):249\u2013257","DOI":"10.1086\/430954"},{"key":"2021120906002684400_R45","doi-asserted-by":"crossref","unstructured":"Madhi SA, Klugman KP. A role for Streptococcus pneumoniae in virus-associated pneumonia. Nat Med.\u20082004;10(8):811\u2013813","DOI":"10.1038\/nm1077"},{"key":"2021120906002684400_R46","doi-asserted-by":"crossref","unstructured":"Mills CE, Robins JM, Lipsitch M. Transmissibility of 1918 pandemic influenza. 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Temporal trends of invasive disease due to Streptococcus pneumoniae among children in the Intermountain West: emergence of nonvaccine serogroups. Clin Infect Dis.\u20082005;41(1):21\u201329","DOI":"10.1086\/430604"},{"key":"2021120906002684400_R51","doi-asserted-by":"crossref","unstructured":"Tan T, Mason E, Wald E, et al. Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumonia.Pediatrics.\u20082002;110(1):1\u20136","DOI":"10.1542\/peds.110.1.1"},{"key":"2021120906002684400_R52","doi-asserted-by":"crossref","unstructured":"Lipsitch M, O'Neill K, Cordy D, et al. Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. J Infect Dis.\u20082007;196(8):1221\u20131227","DOI":"10.1086\/521831"},{"key":"2021120906002684400_R53","doi-asserted-by":"crossref","unstructured":"Haddad MB, Porucznik CA, Joyce KE, et al. 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