{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:08:13Z","timestamp":1793146093761,"version":"4.5.0"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>OBJECTIVE. The aim of our population-based study was to compare the mortality and morbidity of late-preterm infants to those born at term. Advancement in the care of extremely preterm infants has led to a shift of focus away from the more mature preterms, who are being managed as \u201cnear terms\u201d and treated as \u201cnear normal.\u201d Some recent studies have suggested an increased risk of mortality and morbidity in this group compared with infants born at term. However, there are few population-based mortality and morbidity statistics for this cohort, particularly reflecting current practice.<\/jats:p>\n               <jats:p>METHODS. Using data from the British Columbia Perinatal Database Registry we analyzed all singleton births between 33 and 40 weeks\u2019 gestation from April 1999 to March 2002 in the province of British Columbia, Canada. We divided this birth cohort into late preterm (33\u201336 weeks, n = 6381) and term (37\u201340 weeks, n = 88 867) groups. We compared mortality and morbidity data and associated maternal factors between the 2 groups.<\/jats:p>\n               <jats:p>RESULTS. Stillbirth rate and perinatal, neonatal, and infant mortality rates were significantly higher in the late-preterm group. Infants in this group needed resuscitation at birth more frequently than those in the term group. Late-preterm infants had a significantly higher incidence of respiratory morbidity and infection and had a significantly longer duration of hospital stay. Maternal factors that were more common in the late-preterm group included chorioamnionitis, hypertension, diabetes, thrombophilia, prelabor rupture of membranes, primigravida, and teenage pregnancy.<\/jats:p>\n               <jats:p>CONCLUSIONS. Our data support recent literature regarding neonatal mortality and morbidity in late-preterm infants and warrants a review of care for this group at the local, national, and global levels. Reorganization of services and increased resource allocation may be needed in most hospitals and community settings to achieve optimization of care for this group of infants.<\/jats:p>","DOI":"10.1542\/peds.2007-3743","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T15:58:03Z","timestamp":1230566283000},"page":"109-113","source":"Crossref","is-referenced-by-count":186,"title":["Perinatal Outcomes Associated With Preterm Birth at 33 to 36 Weeks\u2019 Gestation: A Population-Based Cohort Study"],"prefix":"10.1542","volume":"123","author":[{"given":"Minesh","family":"Khashu","sequence":"first","affiliation":[{"name":"Neonatal Service, Poole Hospital NHS Foundation Trust, Dorset, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjith","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Division of Child Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Osiovich","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"2021120905091943900_R1","doi-asserted-by":"crossref","unstructured":"Tin W, Wariyar U, Hey E. Changing prognosis for babies of less than 28 weeks\u2019 gestation in the North of England between 1983 and 1994. Northern Neonatal Network. BMJ.\u20081997;314(7074):107\u2013111","DOI":"10.1136\/bmj.314.7074.107"},{"key":"2021120905091943900_R2","doi-asserted-by":"crossref","unstructured":"Draper ES, Manktelow B, Field DJ, James D. Prediction of survival for preterm births by weight and gestational age: retrospective population based study. BMJ.\u20081999;319(7217):1093\u20131097","DOI":"10.1136\/bmj.319.7217.1093"},{"key":"2021120905091943900_R3","doi-asserted-by":"crossref","unstructured":"Stoelhorst GM, Rijken M, Martens SE, et al. Changes in neonatology: comparison of two cohorts of very preterm infants (gestational age &lt;32 weeks): the Project on Preterm and Small for Gestational Age Infants 1983 and the Leiden Follow-up Project on Prematurity 1996\u20131997. 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Semin Perinatol.\u20082006;30(1):24\u201327","DOI":"10.1053\/j.semperi.2006.01.014"},{"key":"2021120905091943900_R7","doi-asserted-by":"crossref","unstructured":"Stark AR. Levels of neonatal care [published correction appears in Pediatrics. 2005;115(4):1118]. Pediatrics.\u20082004;114(5):1341\u20131347","DOI":"10.1542\/peds.2004-1697"},{"key":"2021120905091943900_R8","doi-asserted-by":"crossref","unstructured":"Engle WA, Tomashek KM, Wallman C; American Academy of Pediatrics, Committee on Fetus and Newborn. \u201cLate-preterm\u201d infants: a population at risk [published correction appears in Pediatrics. 2008;121(2):451]. Pediatrics.\u20082007;120(6):1390\u20131401","DOI":"10.1542\/peds.2007-2952"},{"key":"2021120905091943900_R9","doi-asserted-by":"crossref","unstructured":"Jenkins AW. Near-term but still a preemie. 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BMC Pregnancy Childbirth.\u20082003;3(1):3","DOI":"10.1186\/1471-2393-3-3"},{"key":"2021120905091943900_R13","unstructured":"Confidential Enquiry Into Maternal and Child Health. Perinatal Mortality Surveillance, 2004: England, Wales and Northern Ireland. London, United Kingdom: Confidential Enquiry Into Maternal and Child Health; 2006"},{"key":"2021120905091943900_R14","doi-asserted-by":"crossref","unstructured":"Hilder L, Costeloe K, Thilaganathan B. Prolonged pregnancy: evaluating gestation-specific risks of fetal and infant mortality. Br J Obstet Gynaecol.\u20081998;105(2):169\u2013173","DOI":"10.1111\/j.1471-0528.1998.tb10047.x"},{"key":"2021120905091943900_R15","doi-asserted-by":"crossref","unstructured":"Alexander GR, Kogan M, Bader D, Carlo W, Allen M, Mor J. US birth weight\/gestational age-specific neonatal mortality: 1995\u20131997 rates for whites, hispanics, and blacks. Pediatrics.\u20082003;111(1). 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