{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:32Z","timestamp":1791274412011,"version":"4.1.0"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>OBJECTIVE. Our aim was to investigate the role of measles vaccination and measles infection in the development of allergic disease and atopic sensitization.<\/jats:p>\n               <jats:p>METHODS. A total of 14 893 children were included from the cross-sectional, multicenter Prevention of Allergy\u2013Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle study, conducted in 5 European countries (Austria, Germany, the Netherlands, Sweden, and Switzerland). The children were between 5 and 13 years of age and represented farm children, Steiner-school children, and 2 reference groups. Children attending Steiner schools often have an anthroposophic (holistic) lifestyle in which some immunizations are avoided or postponed. Parental questionnaires provided information on exposure and lifestyle factors as well as symptoms and diagnoses in the children. A sample of the children was invited for additional tests, and 4049 children provided a blood sample for immunoglobulin E analyses. Only children with complete information on measles vaccination and infection were included in the analyses (84%).<\/jats:p>\n               <jats:p>RESULTS. In the whole group of children, atopic sensitization was inversely associated with measles infection, and a similar tendency was seen for measles vaccination. To reduce risks of disease-related modification of exposure, children who reported symptoms of wheezing and\/or eczema debuting during first year of life were excluded from some analyses. After this exclusion, inverse associations were observed between measles infection and \u201cany allergic symptom\u201d and \u201cany diagnosis of allergy by a physician.\u201d However, no associations were found between measles vaccination and allergic disease.<\/jats:p>\n               <jats:p>CONCLUSION. Our data suggest that measles infection may protect against allergic disease in children.<\/jats:p>","DOI":"10.1542\/peds.2008-0013","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T12:49:02Z","timestamp":1235998142000},"page":"771-778","source":"Crossref","is-referenced-by-count":41,"title":["Allergic Disease and Atopic Sensitization in Children in Relation to Measles Vaccination and Measles Infection"],"prefix":"10.1542","volume":"123","author":[{"given":"Helen","family":"Rosenlund","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine"},{"name":"Centre for Allergy Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bergstro\u0308m","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan S.","family":"Alm","sequence":"additional","affiliation":[{"name":"Section of Pediatrics, Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden"},{"name":"Section of Pediatrics, Sachs' Children's Hospital, So\u0308dersjukhuset, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Swartz","sequence":"additional","affiliation":[{"name":"Vidar Clinic, Ja\u0308rna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Scheynius","sequence":"additional","affiliation":[{"name":"Clinical Allergy Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"van Hage","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Brunekreef","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"von Mutius","sequence":"additional","affiliation":[{"name":"Dr von Hauner Children's Hospital, University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Ege","sequence":"additional","affiliation":[{"name":"Dr von Hauner Children's Hospital, University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Riedler","sequence":"additional","affiliation":[{"name":"Children's Hospital, Schwarzach, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Braun-Fahrla\u0308nder","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Waser","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go\u0308ran","family":"Pershagen","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine"},{"name":"Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the PARSIFAL Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2021120902461356800_R1","doi-asserted-by":"crossref","unstructured":"Von Hertzen LC, Haahtela T. 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