{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:51:18Z","timestamp":1774122678107,"version":"3.50.1"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>BACKGROUND. In industrialized countries vaccination coverage remains suboptimal, partly because of perception of an increased risk of asthma. Epidemiologic studies of the association between childhood vaccinations and asthma have provided conflicting results, possibly for methodologic reasons such as unreliable vaccination data, biased reporting, and reverse causation. A recent review stressed the need for additional, adequately controlled large-scale studies.<\/jats:p>\n               <jats:p>OBJECTIVE. Our goal was to determine if routine childhood vaccination against pertussis was associated with subsequent development of childhood wheezing disorders and asthma in a large population-based cohort study.<\/jats:p>\n               <jats:p>METHODS. In 6811 children from the general population born between 1993 and 1997 in Leicestershire, United Kingdom, respiratory symptom data from repeated questionnaire surveys up to 2003 were linked to independently collected vaccination data from the National Health Service database. We compared incident wheeze and asthma between children of different vaccination status (complete, partial, and no vaccination against pertussis) by computing hazard ratios. Analyses were based on 6048 children, 23 201 person-years of follow-up, and 2426 cases of new-onset wheeze.<\/jats:p>\n               <jats:p>RESULTS. There was no evidence for an increased risk of wheeze or asthma in children vaccinated against pertussis compared with nonvaccinated children. Adjusted hazard ratios comparing fully and partially vaccinated with nonvaccinated children were close to one for both incident wheeze and asthma.<\/jats:p>\n               <jats:p>CONCLUSION. This study provides no evidence of an association between vaccination against pertussis in infancy and an increased risk of later wheeze or asthma and does not support claims that vaccination against pertussis might significantly increase the risk of childhood asthma.<\/jats:p>","DOI":"10.1542\/peds.2008-0115","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T12:49:02Z","timestamp":1235998142000},"page":"944-950","source":"Crossref","is-referenced-by-count":24,"title":["Routine Vaccination Against Pertussis and the Risk of Childhood Asthma: A Population-Based Cohort Study"],"prefix":"10.1542","volume":"123","author":[{"given":"Ben D.","family":"Spycher","sequence":"first","affiliation":[{"name":"Swiss Pediatric Respiratory Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Silverman","sequence":"additional","affiliation":[{"name":"Leicester Children's Asthma Centre, Division of Child Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Egger","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Respiratory Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Zwahlen","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Respiratory Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E.","family":"Kuehni","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Respiratory Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2021120902522614400_R1","doi-asserted-by":"crossref","unstructured":"Omer SB, Pan WK, Halsey NA, et al. Nonmedical exemptions to school immunization requirements: secular trends and association of state policies with pertussis incidence. JAMA.\u20082006;296(14):1757\u20131763","DOI":"10.1001\/jama.296.14.1757"},{"key":"2021120902522614400_R2","doi-asserted-by":"crossref","unstructured":"Parker AA, Staggs W, Dayan GH, et al. Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States. N Engl J Med.\u20082006;355(5):447\u2013455","DOI":"10.1056\/NEJMoa060775"},{"key":"2021120902522614400_R3","doi-asserted-by":"crossref","unstructured":"Feikin DR, Lezotte DC, Hamman RF, Salmon DA, Chen RT, Hoffman RE. Individual and community risks of measles and pertussis associated with personal exemptions to immunization. JAMA.\u20082000;284(24):3145\u20133150","DOI":"10.1001\/jama.284.24.3145"},{"key":"2021120902522614400_R4","doi-asserted-by":"crossref","unstructured":"Salmon DA, Moulton LH, Omer SB, DeHart MP, Stokley S, Halsey NA. Factors associated with refusal of childhood vaccines among parents of school-aged children: a case-control study. Arch Pediatr Adolesc Med.\u20082005;159(5):470\u2013476","DOI":"10.1001\/archpedi.159.5.470"},{"key":"2021120902522614400_R5","doi-asserted-by":"crossref","unstructured":"Roberts RJ, Sandifer QD, Evans MR, Nolan-Farrell MZ, Davis PM. Reasons for non-uptake of measles, mumps, and rubella catch up immunisation in a measles epidemic and side effects of the vaccine. BMJ.\u20081995;310(6995):1629\u20131632","DOI":"10.1136\/bmj.310.6995.1629"},{"key":"2021120902522614400_R6","doi-asserted-by":"crossref","unstructured":"Havinga W. Risk of asthma. Lancet.\u20082001;357(9252):313\u2013314","DOI":"10.1016\/S0140-6736(05)71762-1"},{"key":"2021120902522614400_R7","doi-asserted-by":"crossref","unstructured":"Odent MR, Culpin EE, Kimel T. Pertussis vaccination and asthma: is there a link?JAMA.\u20081994;272(8):592\u2013593","DOI":"10.1001\/jama.272.8.592a"},{"key":"2021120902522614400_R8","doi-asserted-by":"crossref","unstructured":"Kemp T, Pearce N, Fitzharris P, et al. Is infant immunization a risk factor for childhood asthma or allergy?Epidemiology.\u20081997;8(6):678\u2013680","DOI":"10.1097\/00001648-199711000-00015"},{"key":"2021120902522614400_R9","doi-asserted-by":"crossref","unstructured":"Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax.\u20081998;53(11):927\u2013932","DOI":"10.1136\/thx.53.11.927"},{"key":"2021120902522614400_R10","doi-asserted-by":"crossref","unstructured":"Hurwitz EL, Morgenstern H. Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States. J Manipulative Physiol Ther.\u20082000;23(2):81\u201390","DOI":"10.1016\/S0161-4754(00)90072-1"},{"key":"2021120902522614400_R11","doi-asserted-by":"crossref","unstructured":"Enriquez R, Addington W, Davis F, et al. The relationship between vaccine refusal and self-report of atopic disease in children. J Allergy Clin Immunol.\u20082005;115(4):737\u2013744","DOI":"10.1016\/j.jaci.2004.12.1128"},{"key":"2021120902522614400_R12","doi-asserted-by":"crossref","unstructured":"Nilsson L, Kjellman NI, Bjorksten B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med.\u20081998;152(8):734\u2013738","DOI":"10.1001\/archpedi.152.8.734"},{"key":"2021120902522614400_R13","doi-asserted-by":"crossref","unstructured":"Nilsson L, Kjellman NI, Bjorksten B. Allergic disease at the age of 7 years after pertussis vaccination in infancy: results from the follow-up of a randomized controlled trial of 3 vaccines. 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Available at: www.pediatrics.org\/cgi\/content\/full\/119\/2\/e367","DOI":"10.1542\/peds.2006-1479"},{"key":"2021120902522614400_R22","doi-asserted-by":"crossref","unstructured":"Nakajima K, Dharmage SC, Carlin JB, et al. Is childhood immunisation associated with atopic disease from age 7 to 32 years?Thorax.\u20082007;62(3):270\u2013275","DOI":"10.1136\/thx.2006.062547"},{"key":"2021120902522614400_R23","doi-asserted-by":"crossref","unstructured":"McKeever TM, Lewis SA, Smith C, Hubbard R. Vaccination and allergic disease: a birth cohort study. Am J Public Health.\u20082004;94(6):985\u2013989","DOI":"10.2105\/AJPH.94.6.985"},{"key":"2021120902522614400_R24","doi-asserted-by":"crossref","unstructured":"Gru\u0308ber C, Illi S, Lau S, et al. Transient suppression of atopy in early childhood is associated with high vaccination coverage. Pediatrics.\u20082003;111(3). 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Are all wheezing disorders in very young (preschool) children increasing in prevalence?Lancet.\u20082001;357(9271):1821\u20131825","DOI":"10.1016\/S0140-6736(00)04958-8"},{"key":"2021120902522614400_R31","doi-asserted-by":"crossref","unstructured":"Pierse N, Rushton L, Harris RS, Kuehni CE, Silverman M, Grigg J. Locally-generated particulate pollution and respiratory symptoms in young children. Thorax.\u20082006;61(3):216\u2013220","DOI":"10.1136\/thx.2004.036418"},{"key":"2021120902522614400_R32","doi-asserted-by":"crossref","unstructured":"Michel G, Silverman M, Strippoli M-PF, et al. Parental understanding of \u201cwheeze\u201d and its impact on asthma estimates. Eur Respir J.\u20082006;28(6):1124\u20131130","DOI":"10.1183\/09031936.06.00008406"},{"key":"2021120902522614400_R33","unstructured":"Jenner E. Immunisation Against Infectious Disease. 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Lack of association between pertussis vaccination and symptoms of asthma and allergy. JAMA.\u20081996;275(10):760","DOI":"10.1001\/jama.1996.03530340024024"},{"key":"2021120902522614400_R38","doi-asserted-by":"crossref","unstructured":"Kuehni CE, Strippoli M-PF, Zwahlen M, Silverman M. Association between reported exposure to road traffic and respiratory symptoms in children: evidence of bias. Int J Epidemiol.\u20082006;35(3):779\u2013786","DOI":"10.1093\/ije\/dyl022"},{"key":"2021120902522614400_R39","unstructured":"British Thoracic Society, Scottish Intercollegiate Guidelines Network (SIGN). British guideline on the management of asthma. Thorax.\u20082003;58(suppl 1):i1\u201394"},{"key":"2021120902522614400_R40","doi-asserted-by":"crossref","unstructured":"Dong W, Selgrade MK, Gilmour MI. Systemic administration of Bordetella pertussis enhances pulmonary sensitization to house dust mite in juvenile rats. 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