{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:41:03Z","timestamp":1793018463295,"version":"4.5.0"},"reference-count":42,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:p>OBJECTIVE. The goal was to examine the carbohydrate tolerance and cardiometabolic risk among children exposed to maternal gestational diabetes mellitus in utero.<\/jats:p><jats:p>METHODS. In this study, 164 Chinese children whose mothers had participated in a previous study on the screening and diagnosis of gestational diabetes mellitus (63 had gestational diabetes mellitus and 101 had normal glucose tolerance during the index pregnancies) underwent follow-up evaluations at a median age of 8 years (range: 7\u201310 years). Children's weight, height, hip and waist circumferences, and blood pressure were measured, and weight-adjusted oral glucose tolerance tests were performed.<\/jats:p><jats:p>RESULTS. Six children (3.7%) demonstrated impaired glucose regulation or diabetes mellitus at the follow-up evaluation. Children exposed to maternal gestational diabetes mellitus had significantly higher systolic (94 \u00b1 1.2 vs 88 \u00b1 0.9 mmHg) and diastolic (62 \u00b1 0.8 vs 57 \u00b1 0.6 mmHg) blood pressure values and lower high-density lipoprotein cholesterol (1.58 \u00b1 0.04 vs 1.71 \u00b1 0.03 mmol\/L) levels, after adjustment for age and gender. A high (\u226590th percentile) umbilical cord insulin level at birth was associated with abnormal glucose tolerance in the offspring.<\/jats:p><jats:p>CONCLUSIONS. Maternal gestational diabetes mellitus increases the offspring's cardiometabolic risk, and in utero hyperinsulinemia is an independent predictor of abnormal glucose tolerance in childhood.<\/jats:p>","DOI":"10.1542\/peds.2008-0158","type":"journal-article","created":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T14:23:01Z","timestamp":1228141381000},"page":"1229-1234","source":"Crossref","is-referenced-by-count":132,"title":["Glucose Intolerance and Cardiometabolic Risk in Children Exposed to Maternal Gestational Diabetes Mellitus in Utero"],"prefix":"10.1542","volume":"122","author":[{"given":"Wing Hung","family":"Tam","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynaecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Ching Wan","family":"Ma","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary Tin Choi","family":"Ko","sequence":"additional","affiliation":[{"name":"Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong Special Administrative Region"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Chun Yip","family":"Tong","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive Stewart","family":"Cockram","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljit Singh","family":"Sahota","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Scott","family":"Rogers","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Chung Ngor","family":"Chan","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"2021120820195876300_R1","doi-asserted-by":"crossref","unstructured":"Aanstoot H-J, Anderson BJ, Daneman D, et al. 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N Engl J Med.\u20082004;350(23):2362\u20132374","DOI":"10.1056\/NEJMoa031049"},{"key":"2021120820195876300_R6","doi-asserted-by":"crossref","unstructured":"Csa\u0301bi G, To\u0308ro\u0308k K, Jeges S, Molna\u0301r D. Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr.\u20082000;159(1\u20132):91\u201394","DOI":"10.1007\/PL00013812"},{"key":"2021120820195876300_R7","doi-asserted-by":"crossref","unstructured":"Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab.\u20082004;89(1):108\u2013113","DOI":"10.1210\/jc.2003-031188"},{"key":"2021120820195876300_R8","doi-asserted-by":"crossref","unstructured":"Eisenmann JC. Secular trends in variables associated with the metabolic syndrome of North American children and adolescents: a review and synthesis. Am J Hum Biol.\u20082003;15(6):786\u2013794","DOI":"10.1002\/ajhb.10214"},{"key":"2021120820195876300_R9","doi-asserted-by":"crossref","unstructured":"Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV. Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children. Diabetologia.\u20081996;39(12):1489\u20131497","DOI":"10.1007\/s001250050603"},{"key":"2021120820195876300_R10","doi-asserted-by":"crossref","unstructured":"Caprio S, Tamborlane WV. Metabolic impact of obesity in childhood. Endocrinol Metab Clin North Am.\u20081999;28(4):731\u2013747","DOI":"10.1016\/S0889-8529(05)70099-2"},{"key":"2021120820195876300_R11","unstructured":"Caprio S. Insulin resistance in childhood obesity. J Pediatr Endocrinol Metab.\u20082002;15(suppl 1):487\u2013492"},{"key":"2021120820195876300_R12","doi-asserted-by":"crossref","unstructured":"Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the Third National Health and Nutrition Examination Survey, 1988\u20131994. Arch Pediatr Adolesc Med.\u20082003;157(8):821\u2013827","DOI":"10.1001\/archpedi.157.8.821"},{"key":"2021120820195876300_R13","doi-asserted-by":"crossref","unstructured":"Barker DJ, Barker DJP. The origins of the developmental origins theory. J Intern Med.\u20082007;261(5):412\u2013417","DOI":"10.1111\/j.1365-2796.2007.01809.x"},{"key":"2021120820195876300_R14","doi-asserted-by":"crossref","unstructured":"Barker DJ, Barker DJP. The developmental origins of insulin resistance. Horm Res.\u20082005;64(suppl 3):2\u20137","DOI":"10.1159\/000089311"},{"key":"2021120820195876300_R15","doi-asserted-by":"crossref","unstructured":"Barker DJ, Bagby SP, Hanson MA, Barker DJP, Bagby SP, Hanson MA. Mechanisms of disease: in utero programming in the pathogenesis of hypertension. 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Available at: www.pediatrics.org\/cgi\/content\/full\/115\/3\/e290","DOI":"10.1542\/peds.2004-1808"},{"key":"2021120820195876300_R22","doi-asserted-by":"crossref","unstructured":"Fung H, Wong S, Rogers M. The influence of glucose tolerance tests on subsequent carbohydrate metabolism in pregnancy. Acta Obstet Gynecol Scand.\u20081996;75(4):347\u2013351","DOI":"10.3109\/00016349609033329"},{"key":"2021120820195876300_R23","doi-asserted-by":"crossref","unstructured":"Tam WH, Rogers MS, Yip SK, Lau TK, Leung TY. Which screening test is the best for gestational impaired glucose tolerance and gestational diabetes mellitus?Diabetes Care.\u20082000;23(9):1432","DOI":"10.2337\/diacare.23.9.1432b"},{"key":"2021120820195876300_R24","unstructured":"World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation, Part 1: Diagnosis and Classification of Diabetes Mellitus. 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