{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:57:02Z","timestamp":1760014622575,"version":"3.40.5"},"reference-count":47,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>OBJECTIVE. There are few recent population-based assessments of vaccine coverage in premature infants available. This study assesses and compares age- and dose-specific immunization coverage in children of different birth weight categories during the first year of life.<\/jats:p><jats:p>METHODS. We performed a retrospective cohort analysis of computerized vaccination data from a large managed care organization in southern California. The participants were children born between January 1, 1997, and December 31, 2002, and continuously enrolled from birth to at least 12 months of age in the Southern California Kaiser Permanente health plan. We measured age-specific up-to-date and age-appropriate immunization rates according to birth weight (extremely low birth weight: &amp;lt;1000 g; very low birth weight: 1000\u20131499 g; low birth weight: 1500\u20132499 g; normal birth weight: \u22652500 g) for 4 vaccines (hepatitis B, diphtheria and tetanus toxoids with pertussis, Haemophilus influenzae type b, and poliovirus) through the first year of life.<\/jats:p><jats:p>RESULTS. We identified 127 833 infants born during the study period and continuously enrolled through the first year of life; 120 048 were normal birth weight infants; 6491 were low birth weight infants; 788 were very low birth weight infants; and 506 were extremely low birth weight infants. Vaccine-specific age-appropriate immunization rates were 3% to 15% lower for low birth weight infants and 17% to 33% lower for extremely low birth weight infants compared with the rates for normal birth weight infants in the first 6 months of life. Extremely low birth weight infants had the lowest age-specific up-to-date immunization levels (5%\u201331% lower) compared with normal birth weight infants at each age assessed. By 12 months, extremely low birth weight infants still had significantly lower up-to-date levels (87%) compared with very low birth weight, low birth weight, and normal birth weight infants (91%\u201392%).<\/jats:p><jats:p>CONCLUSIONS. Despite recommendations that lower birth weight infants be vaccinated as the same chronological age as normal birth weight infants, extremely low birth weight and very low birth weight infants are immunized at significantly lower rates relative to low birth weight and normal birth weight infants at 2, 4, and 6 months of age. However, by 12 months of age this finding persists only in extremely low birth weight infants.<\/jats:p>","DOI":"10.1542\/peds.2008-0231","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T12:49:02Z","timestamp":1235998142000},"page":"951-958","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of Vaccine Coverage for Low Birth Weight Infants During the First Year of Life in a Large Managed Care Population"],"prefix":"10.1542","volume":"123","author":[{"given":"Jagmohan S.","family":"Batra","sequence":"first","affiliation":[{"name":"UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Eriksen","sequence":"additional","affiliation":[{"name":"UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Zangwill","sequence":"additional","affiliation":[{"name":"UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lee","sequence":"additional","affiliation":[{"name":"UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Michael","family":"Marcy","sequence":"additional","affiliation":[{"name":"UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"},{"name":"Department of Pediatrics, Kaiser Foundation Hospital, Panorama City, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel I.","family":"Ward","sequence":"additional","affiliation":[{"name":"UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Vaccine Safety Datalink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2021120902510781800_R1","doi-asserted-by":"crossref","unstructured":"Hoppe JE. Neonatal pertussis. Pediatr Infect Dis J.\u20082000;19(3):244\u2013247","DOI":"10.1097\/00006454-200003000-00014"},{"key":"2021120902510781800_R2","doi-asserted-by":"crossref","unstructured":"Langkamp DL, Davis JP. Increased risk of reported pertussis and hospitalization associated with pertussis in low birth weight children. J Pediatr.\u20081996;128(5 pt 1):654\u2013659","DOI":"10.1016\/S0022-3476(96)80131-4"},{"key":"2021120902510781800_R3","doi-asserted-by":"crossref","unstructured":"Saari TN; American Academy of Pediatrics, Committee on Infectious Diseases. Immunization of preterm and low birth weight infants. Pediatrics.\u20082003;112(1 pt 1):193\u2013198","DOI":"10.1542\/peds.112.1.193"},{"key":"2021120902510781800_R4","unstructured":"American Academy of Pediatrics, Committee on Infectious Diseases. Immunization in special clinical circumstances: preterm infants. In: Peter G, ed. 1997 Red Book: Report of the Committee on Infectious Diseases. 24th ed. Elk Grove Village, IL: American Academy of Pediatrics;1997:48"},{"key":"2021120902510781800_R5","unstructured":"Magoon MW, Belardo LJ, Caldito G. Delays in immunizations of high-risk infants during the first 2 years of life: special care for the high-risk infant should not mean special immunization schedules. J Perinatol.\u20081995;15(3):222\u2013228"},{"key":"2021120902510781800_R6","doi-asserted-by":"crossref","unstructured":"Roper J, Day S. Uptake of immunisations in low birthweight infants. Arch Dis Child.\u20081988;63(5):518\u2013521","DOI":"10.1136\/adc.63.5.518"},{"key":"2021120902510781800_R7","doi-asserted-by":"crossref","unstructured":"Vohr BR, Oh W. Age of diphtheria, tetanus, and pertussis immunization of special care nursery graduates. Pediatrics.\u20081986;77(4):569\u2013571","DOI":"10.1542\/peds.77.4.569"},{"key":"2021120902510781800_R8","doi-asserted-by":"crossref","unstructured":"Langkamp DL, Langhough R. 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Pediatr Infect Dis J.\u20081993;12(4):353\u2013354","DOI":"10.1097\/00006454-199304000-00022"},{"key":"2021120902510781800_R32","doi-asserted-by":"crossref","unstructured":"Dominguez SR, Parrott JS, Lauderdale DS, Daum RS. On-time immunization rates among children who enter Chicago public schools. Pediatrics.\u20082004;114(6). Available at: www.pediatrics.org\/cgi\/content\/full\/114\/6\/e741","DOI":"10.1542\/peds.2004-1053"},{"key":"2021120902510781800_R33","doi-asserted-by":"crossref","unstructured":"Alexander GR, Kogan M, Bader D, Carlo W, Allen M, Mor J. US birth weight\/gestational age-specific neonatal mortality: 1995\u20131997 rates for whites, Hispanics, and blacks. Pediatrics.\u20082003;111(1). Available at: www.pediatrics.org\/cgi\/content\/full\/111\/1\/e61","DOI":"10.1542\/peds.111.1.e61"},{"key":"2021120902510781800_R34","doi-asserted-by":"crossref","unstructured":"David RJ, Collins JW. 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Am J Prev Med.\u20082001;20(4 Suppl):61\u201368","DOI":"10.1016\/S0749-3797(01)00278-1"},{"key":"2021120902510781800_R38","doi-asserted-by":"crossref","unstructured":"Herrera GA, Zhao Z, Klevens M. Variation in vaccination coverage among children of Hispanic ancestry. Am J Prev Med.\u20082001;20(4 Suppl):69\u201374","DOI":"10.1016\/S0749-3797(01)00277-X"},{"key":"2021120902510781800_R39","doi-asserted-by":"crossref","unstructured":"Szilagyi PG, Schaffer S, Shone L, et al. Reducing geographic, racial, and ethnic disparities in childhood immunization rates by using reminder\/recall interventions in urban primary care practices. Pediatrics.\u20082002;110(5). Available at: www.pediatrics.org\/cgi\/content\/full\/110\/5\/e58","DOI":"10.1542\/peds.110.5.e58"},{"key":"2021120902510781800_R40","doi-asserted-by":"crossref","unstructured":"Wood D, Donald-Sherbourne C, Halfon N, et al. Factors related to immunization status among inner-city Latino and African American preschoolers. 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