{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:53:13Z","timestamp":1768564393510,"version":"3.49.0"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:p>OBJECTIVE. Patent ductus arteriosus is a common morbidity associated with preterm birth. The incidence of patent ductus arteriosus increases with decreasing gestational age to \u223c70% in infants born at 25 weeks' gestation. Our major goal was to determine if genetic risk factors play a role in patent ductus arteriosus seen in preterm infants.<\/jats:p>\n               <jats:p>METHODOLOGY. We investigated whether single-nucleotide polymorphisms in genes that regulate smooth muscle contraction, xenobiotic detoxification, inflammation, and other processes are markers for persistent patency of ductus arteriosus. Initially, 377 single-nucleotide polymorphisms from 130 genes of interest were evaluated in DNA samples collected from 204 infants with a gestational age of &amp;lt;32 weeks. A family-based association test was performed on genotyping data to evaluate overtransmission of alleles.<\/jats:p>\n               <jats:p>RESULTS. P values of &amp;lt;.01 were detected for genetic variations found in 7 genes. This prompted additional analysis with an additional set of 162 infants, focusing on the 7 markers with initial P values of &amp;lt;.01, and 1 genetic variant in the angiotensin II type I receptor previously shown to be related to patent ductus arteriosus. Of the initial positive signals, single-nucleotide polymorphisms in the transcription factor AP-2 \u03b2 and tumor necrosis factor receptor\u2013associated factor 1 genes remained significant. Additional haplotype analysis revealed genetic variations in prostacyclin synthase to be associated with patent ductus arteriosus. An angiotensin II type I receptor polymorphism previously reported to be associated with patent ductus arteriosus after prophylactic indomethacin administration was not associated with the presence of a patent ductus arteriosus in our population.<\/jats:p>\n               <jats:p>CONCLUSIONS. Overall, our data support a role for genetic variations in transcription factor AP-2 \u03b2, tumor necrosis factor receptor\u2013associated factor 1, and prostacyclin synthase in the persistent patency of the ductus arteriosus seen in preterm infants.<\/jats:p>","DOI":"10.1542\/peds.2008-0313","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T23:05:24Z","timestamp":1238454324000},"page":"1116-1123","source":"Crossref","is-referenced-by-count":61,"title":["Determination of Genetic Predisposition to Patent Ductus Arteriosus in Preterm Infants"],"prefix":"10.1542","volume":"123","author":[{"given":"John M.","family":"Dagle","sequence":"first","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan T.","family":"Lepp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Center for Craniofacial and Dental Genetics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra L.","family":"Schaa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keegan J.P.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin L.","family":"Orr","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Caprau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara R.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine M.","family":"Steffen","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Marazita","sequence":"additional","affiliation":[{"name":"Center for Craniofacial and Dental Genetics"},{"name":"Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,4,1]]},"reference":[{"key":"2021120902354239400_R1","doi-asserted-by":"crossref","unstructured":"Hermes-DeSantis ER, Clyman RI. 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