{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:00:39Z","timestamp":1790164839407,"version":"4.1.0"},"reference-count":60,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:p>BACKGROUND. Studies of the relationship between ultrasound images from preterm newborns and developmental delay most often are based on small samples defined by birth weight and exclude infants not testable with standardized assessments.<\/jats:p><jats:p>METHODS. We evaluated associations between ultrasound-defined lesions of the brain and developmental delays at 24 months\u2019 corrected age in 1017 children born before the 28th postmenstrual week. Brain ultrasound scans were read for concordance on 4 lesions: intraventricular hemorrhage, moderate\/severe ventriculomegaly, white matter echodense\/hyperechoic lesions, and white matter echodense\/hypoechoic lesions and 2 diagnoses\u2013periventricular leukomalacia and periventricular hemorrhagic infarction. Certified examiners, who were not aware of the infants\u2019 ultrasound findings, administered the Bayley Scales of Infant Development-Second Edition. Children with an impairment (eg., blindness) that precluded testing with the Bayley Scales and those for whom &amp;gt;2 test items were omitted were classified using the Vineland Adaptive Behavior Scales Motor Skills Domain instead of the Psychomotor Development Index and the Adaptive Behavior Composite instead of the Mental Development Index.<\/jats:p><jats:p>RESULTS. Fully 26% of all of the children had delayed mental development (ie, Mental Development Index &amp;lt; 70), and 31% had delayed psychomotor development (ie, Psychomotor Development Index &amp;lt; 70). Ultrasound abnormalities were more strongly associated with low Psychomotor Development Index than with low Mental Development Index. Children without cranial ultrasound abnormality had the lowest probability (23% and 26%) of delayed mental or psychomotor development. Moderate\/severe ventriculomegaly was associated with a more than fourfold increase in the risk of psychomotor delay and an almost threefold increase in the risk of mental delay. Echolucency was the next best predictor of delayed mental and psychomotor development. The probability of low scores varied with the number of zones involved and with the location of echolucency. At particularly high risk were infants with bilateral cerebellar hemorrhage, co-occurring ventriculomegaly and echolucency bilateral echolucency, or echolucency located posteriorly.<\/jats:p><jats:p>CONCLUSIONS. Focal white matter damage, as characterized by echolucent\/hypoechoic lesion, and diffuse damage, as suggested by late ventriculomegaly, are associated with delayed mental and psychomotor development.<\/jats:p>","DOI":"10.1542\/peds.2008-0594","type":"journal-article","created":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T13:27:57Z","timestamp":1220275677000},"page":"e662-e669","source":"Crossref","is-referenced-by-count":120,"title":["Neonatal Cranial Ultrasound Lesions and Developmental Delays at 2 Years of Age Among Extremely Low Gestational Age Children"],"prefix":"10.1542","volume":"122","author":[{"given":"T. Michael","family":"O'Shea","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Wake Forest University, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl C. K.","family":"Kuban","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth N.","family":"Allred","sequence":"additional","affiliation":[{"name":"Neuroepidemiology Unit, Department of Neurology, Children's Hospital Boston, Harvard University, Boston, Massachusetts"},{"name":"Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Paneth","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Michigan State University, East Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dammann","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bostic","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Brooklier","sequence":"additional","affiliation":[{"name":"Center for Human Development, William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Children's Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wake Forest University, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Hounshell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wake Forest University, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecelia","family":"Keller","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McQuiston","sequence":"additional","affiliation":[{"name":"Baystate Medical Center, Springfield, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Massachusetts-Memorial Health Center, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Pediatric Psychology, DeVos Children's Hospital, Grand Rapids, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Plesha-Troyke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Price","sequence":"additional","affiliation":[{"name":"Early Childhood Services\/Referrals, Michigan State University-Sparrow Medical Center, Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Romano","sequence":"additional","affiliation":[{"name":"Yale University Medical Center, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Center for Human Development, William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjirk","family":"Westra","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Leviton","sequence":"additional","affiliation":[{"name":"Neuroepidemiology Unit, Department of Neurology, Children's Hospital Boston, Harvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Extremely Low Gestational Age Newborns Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"2021120905243972800_R1","doi-asserted-by":"crossref","unstructured":"Ment LR, Bada HS, Barnes P, et al. Practice parameter: neuroimaging of the neonate-report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology.\u20082002;58(12):1726\u20131738","DOI":"10.1212\/WNL.58.12.1726"},{"key":"2021120905243972800_R2","unstructured":"Paneth N, Rudelli R, Kazam E, Monte W. Prognosis. In: Paneth N, Rudelli R, Kazam E, Monte W, eds. Brain Damage in the Preterm Infant. London, United Kingdom: Cambridge University Press;1994:171\u2013185"},{"key":"2021120905243972800_R3","doi-asserted-by":"crossref","unstructured":"Holling EE, Leviton A. Characteristics of cranial ultrasound white-matter echolucencies that predict disability: a review. Dev Med Child Neurol.\u20081999;41(2):136\u2013139","DOI":"10.1017\/S0012162299000262"},{"key":"2021120905243972800_R4","doi-asserted-by":"crossref","unstructured":"Paneth N. Classifying brain damage in preterm infants. 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J Pediatr.\u20082004;144(6):815\u2013820","DOI":"10.1016\/j.jpeds.2004.03.034"},{"key":"2021120905243972800_R10","doi-asserted-by":"crossref","unstructured":"Stewart AL, Reynolds EO, Hope PL, et al. Probability of neurodevelopmental disorders estimated from ultrasound appearance of brains of very preterm infants. Dev Med Child Neurol.\u20081987;29(1):3\u201311","DOI":"10.1111\/j.1469-8749.1987.tb02101.x"},{"key":"2021120905243972800_R11","doi-asserted-by":"crossref","unstructured":"Roth SD, Baudin J, Pezzani-Goldsmith M, Townsend J, Reynolds EOR, Stewart AL. Relation between neurodevelopmental status of very preterm infants at one and eight years. Dev Med Child Neurol.\u20081994;36(12):1049\u20131062","DOI":"10.1111\/j.1469-8749.1994.tb11808.x"},{"key":"2021120905243972800_R12","doi-asserted-by":"crossref","unstructured":"Fily A, Pierrat V, Delporte V, Breart G, Truffert P. Factors associated with neurodevelopmental outcome at 2 years after very preterm birth: the population-based Nord-Pas-de-Calais EPIPAGE cohort. Pediatrics.\u20082006;117(2):357\u2013366","DOI":"10.1542\/peds.2005-0236"},{"key":"2021120905243972800_R13","doi-asserted-by":"crossref","unstructured":"Wood NS, Costeloe K, Gibson AT, Hennessy EM, Marlow N, Wilkinson AR. The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth. Arch Dis Child Fetal Neonatal Ed.\u20082005;90(2):F134\u2013F140","DOI":"10.1136\/adc.2004.052407"},{"key":"2021120905243972800_R14","doi-asserted-by":"crossref","unstructured":"Kuban K, Allred E, O'Shea TM, et al. Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children who were born at extremely low gestational age. J Child Neurol.\u20082008; In press","DOI":"10.1177\/0883073808321048"},{"key":"2021120905243972800_R15","unstructured":"Teele R, Share J. Ultrasonography of Infants and Children. Philadelphia, PA: WB Saunders;1991"},{"key":"2021120905243972800_R16","doi-asserted-by":"crossref","unstructured":"Kuban K, Adler I, Allred E, et al. Observer variability assessing US scans of the preterm brain: the ELGAN study. Pediatr Radiol.\u20082007;37(12):1201\u20131208","DOI":"10.1007\/s00247-007-0605-z"},{"key":"2021120905243972800_R17","unstructured":"Sparrow SS, Balla DA, Cicchetti DV. Vineland Adaptive Behavioral Scales. Circle Pines, MN: American Guidance Service;1984"},{"key":"2021120905243972800_R18","unstructured":"Bayley N. Bayley Scales of Infant Development. 2nd ed. San Antonio, TX: Psychological Corporation;1993"},{"key":"2021120905243972800_R19","doi-asserted-by":"crossref","unstructured":"Graziani LJ, Pasto M, Stanley C, et al. Cranial ultrasound and clinical studies in preterm infants. 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Neonatal cranial ultrasound abnormalities-association with developmental delay at age one in low-birth-weight infants. J Dev Behav Pediatrics.\u20081990;11(5):253\u2013260","DOI":"10.1097\/00004703-199010000-00006"},{"key":"2021120905243972800_R23","doi-asserted-by":"crossref","unstructured":"Doyle LW; Victorian Infant Collaborative Study Group. Neonatal intensive care at borderline viability-is it worth it?Early Hum Deve.\u20082004;80(2):103\u2013113","DOI":"10.1016\/j.earlhumdev.2004.05.009"},{"key":"2021120905243972800_R24","doi-asserted-by":"crossref","unstructured":"Laptook AR, O'Shea TM, Shankaran S, Bhaskar B; NICHD Neonatal Network. Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents. Pediatrics.\u20082005;115(3):673\u2013680","DOI":"10.1542\/peds.2004-0667"},{"key":"2021120905243972800_R25","doi-asserted-by":"crossref","unstructured":"Vollmer B, Roth S, Riley K, et al. 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Periventricular leukomalacia: a correlation study between real-time ultrasound and autopsy findings: periventricular leukomalacia in the neonate. Neuroradiology.\u20081985;27(4):292\u2013300","DOI":"10.1007\/BF00339560"},{"key":"2021120905243972800_R29","doi-asserted-by":"crossref","unstructured":"Costeloe K, Hennessy E, Gibson AT, Marlow N, Wilkinson AR. The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics.\u20082000;106(4):659\u2013671","DOI":"10.1542\/peds.106.4.659"},{"key":"2021120905243972800_R30","doi-asserted-by":"crossref","unstructured":"Guzzetta F, Schackelford GD, Volpe S, Perlman JM, Volpe JJ. Periventricular intraparenchymal echodensities in the premature newborn: critical determinant of neurologic outcome. Pediatrics.\u20081986;78(6):995\u20131006","DOI":"10.1542\/peds.78.6.995"},{"key":"2021120905243972800_R31","doi-asserted-by":"crossref","unstructured":"Nwaesei CG, Pape KE, Martin DJ, Becker LE, Fitz CR. 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Obstet Gynecol.\u20081997;90(1):93\u201397","DOI":"10.1016\/S0029-7844(97)00112-9"},{"key":"2021120905243972800_R35","unstructured":"Vasileiadis GT, Gelman N, Williams LA, et al. Uncomplicated intraventricular hemorrhage reduces the cortical gray matter volume in preterm neonates. Pediatr Res.\u20082003;53(4):511A"},{"key":"2021120905243972800_R36","doi-asserted-by":"crossref","unstructured":"Leviton A, Gilles F. Ventriculomegaly, delayed myelination, white matter hypoplasia, and \u201cperiventricular\u201d leukomalacia: how are they related?Pediatr Neurol.\u20081996;15(2):127\u2013136","DOI":"10.1016\/0887-8994(96)00157-9"},{"key":"2021120905243972800_R37","doi-asserted-by":"crossref","unstructured":"Leviton A, Gressens P. Neuronal damage accompanies perinatal white-matter damage. Trends Neurosci.\u20082007;30(9):473\u2013478","DOI":"10.1016\/j.tins.2007.05.009"},{"key":"2021120905243972800_R38","doi-asserted-by":"crossref","unstructured":"Allin M, Matsumoto H, Santhouse AM, et al. 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Pediatrics.\u20082001;107(4):719\u2013727","DOI":"10.1542\/peds.107.4.719"},{"key":"2021120905243972800_R45","doi-asserted-by":"crossref","unstructured":"Paneth N, Rudelli R, Monte W, et al. White matter necrosis in very low birth weight infants: neuropathologic and ultrasonographic findings in infants surviving six days or longer. J Pediatr.\u20081990;116(6):975\u2013984","DOI":"10.1016\/S0022-3476(05)80664-X"},{"key":"2021120905243972800_R46","doi-asserted-by":"crossref","unstructured":"O'Shea TM, Klinepeter KL, Dillard RG. Prenatal events and the risk of cerebral palsy in very low birth weight infants. Am J Epidemiol.\u20081998;147(4):362\u2013369","DOI":"10.1093\/oxfordjournals.aje.a009458"},{"key":"2021120905243972800_R47","doi-asserted-by":"crossref","unstructured":"Wheater M, Rennie JM. Perinatal infection is an important risk factor for cerebral palsy in very-low-birthweight infants. 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N Engl J Med.\u20082006;355(7):685\u2013694","DOI":"10.1056\/NEJMoa053792"},{"key":"2021120905243972800_R51","doi-asserted-by":"crossref","unstructured":"Kiely JL, Paneth N. Follow-up studies of low-birthweight infants: suggestions for design, analysis and reporting. Dev Med Child Neurol.\u20081981;23(1):96\u2013100","DOI":"10.1111\/j.1469-8749.1981.tb08451.x"},{"key":"2021120905243972800_R52","doi-asserted-by":"crossref","unstructured":"Arnold CC, Kramer MS, Hobbs CA, McLean FH, Usher RH. Very low birth weight: a problematic cohort for epidemiologic studies of very small or immature neonates. Am J Epidemiol.\u20081991;134(6):604\u2013613","DOI":"10.1093\/oxfordjournals.aje.a116133"},{"key":"2021120905243972800_R53","doi-asserted-by":"crossref","unstructured":"Sackett DL. Bias in analytic research. 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