{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:36:54Z","timestamp":1787499414247,"version":"build-2736575974"},"reference-count":49,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:p>OBJECTIVE. We tested the hypothesis that single-nucleotide polymorphisms of inflammatory genes C-reactive protein (CRP) and tumor necrosis factor \u03b1 (TNF-\u03b1) may exert influence on susceptibility to Kawasaki disease and its arterial sequelae.<\/jats:p>\n                  <jats:p>METHODS. We analyzed the CRP +1444 C\u2192T and TNF-\u03b1 \u2212308 G\u2192A polymorphisms in 167 patients aged 8.9 \u00b1 4.1 years with a history of Kawasaki disease (73 with and 94 without coronary aneurysms) and 124 healthy control subjects. For patients with Kawasaki disease, we further determined whether these single-nucleotide polymorphisms were associated with coronary aneurysms, carotid arterial stiffening, and intima-media thickness.<\/jats:p>\n                  <jats:p>RESULTS. Genotypic and allelic frequencies of CRP +1444 for T carrier and TNF-\u03b1 \u2212308 for A carrier were significantly higher in patients than in control subjects. The genotypic and allelic distributions did not differ between patients with and those without coronary aneurysms; however, patients with CRP +1444 CT\/TT genotype compared with those with a CC genotype and patients with TNF-\u03b1 \u2212308 GA\/AA genotype compared with those with a GG genotype had significantly greater carotid arterial stiffness and intima-media thickness. Carriers of both CRP +1444 T allele and TNF-\u03b1 \u2212308 A allele had the highest susceptibility to Kawasaki disease and a significant trend of increased arterial stiffness and intima-media thickness compared with those who carried either 1 or none of the rare alleles. Multiple linear regression analysis identified CRP +1444 allele carrier as a significant determinant of both carotid stiffness and carotid intima-media thickness and TNF-\u03b1 \u2212308 A allele carrier as a determinant of only intima-media thickness.<\/jats:p>\n                  <jats:p>CONCLUSIONS. Our findings suggest that CRP +1444 C\u2192T and TNF-\u03b1 \u2212308 G\u2192A polymorphisms are associated with predisposition to Kawasaki disease and, in patients with Kawasaki disease, increased carotid arterial stiffness and intima-media thickness in the long-term.<\/jats:p>","DOI":"10.1542\/peds.2008-0646","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T20:16:16Z","timestamp":1219090576000},"page":"e608-e614","source":"Crossref","is-referenced-by-count":41,"title":["Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae"],"prefix":"10.1542","volume":"122","author":[{"given":"Yiu-fai","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Center, Children's Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-bao","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Children Medical Center, Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Center, Children's Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xi","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Center, Children's Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-cun","family":"Liang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Center, Children's Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Children Medical Center, Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Children Medical Center, Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-su","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Children Medical Center, Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Children Medical Center, Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon-wing","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-lung","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"2021120905250607400_R1","doi-asserted-by":"crossref","unstructured":"Kato H, Sugimura T, Akagi T, et al. Long-term consequences of Kawasaki disease: a 10- to 21-year follow-up study of 594 patients. Circulation.\u20081996;94(6):1379\u20131385","DOI":"10.1161\/01.CIR.94.6.1379"},{"key":"2021120905250607400_R2","doi-asserted-by":"crossref","unstructured":"Sugimura T, Kato H, Inoue O, Takagi J, Fududa T, Sato N. Vasodilatory response of the coronary arteries after Kawasaki disease: evaluation by intracoronary injection of isosorbide dinitrate. J Pediatr.\u20081992;121(5 pt 1):684\u2013688","DOI":"10.1016\/S0022-3476(05)81893-1"},{"key":"2021120905250607400_R3","doi-asserted-by":"crossref","unstructured":"Cheung YF, Yung TC, Tam SC, Ho MH, Chau AK. Novel and traditional cardiovascular risk factors in children after Kawasaki disease: implications for premature atherosclerosis. J Am Coll Cardiol.\u20082004;43(1):120\u2013124","DOI":"10.1016\/j.jacc.2003.08.030"},{"key":"2021120905250607400_R4","doi-asserted-by":"crossref","unstructured":"Cheung YF, Ho MH, Tam SC, Yung TC. Increased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease. Heart.\u20082004;90(11):1281\u20131285","DOI":"10.1136\/hrt.2003.018507"},{"key":"2021120905250607400_R5","doi-asserted-by":"crossref","unstructured":"Noto N, Okada T, Yamasuge M, et al. Noninvasive assessment of the early progression of atherosclerosis in adolescents with Kawasaki disease and coronary artery lesions. Pediatrics.\u20082001;107(5):1095\u20131099","DOI":"10.1542\/peds.107.5.1095"},{"key":"2021120905250607400_R6","doi-asserted-by":"crossref","unstructured":"Dhillon R, Clarkson P, Donald AE, et al. Endothelial dysfunction late after Kawasaki disease. Circulation.\u20081996;94(9):2103\u20132106","DOI":"10.1161\/01.CIR.94.9.2103"},{"key":"2021120905250607400_R7","doi-asserted-by":"crossref","unstructured":"Cheung YF, Wong SJ, Ho MH. Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease. Arch Dis Child.\u20082007;92(1):43\u201347","DOI":"10.1136\/adc.2006.096628"},{"key":"2021120905250607400_R8","doi-asserted-by":"crossref","unstructured":"Dalla Pozza R, Bechtold S, Urschel S, Kozlik-Feldmann R, Netz H. Subclinical atherosclerosis, but normal autonomic function after Kawasaki disease. J Pediatr.\u20082007;151(3):239\u2013243","DOI":"10.1016\/j.jpeds.2007.03.057"},{"key":"2021120905250607400_R9","doi-asserted-by":"crossref","unstructured":"Rowley AH, Shulman ST. Kawasaki syndrome. Pediatr Clin North Am.\u20081999;46(2):313\u2013329","DOI":"10.1016\/S0031-3955(05)70120-6"},{"key":"2021120905250607400_R10","doi-asserted-by":"crossref","unstructured":"Madsen HO, Videm V, Svejgaard A, Svennevig JL, Garred P. Association of mannose-binding-lectin deficiency with severe atherosclerosis. Lancet.\u20081998;352(9132):959\u2013960","DOI":"10.1016\/S0140-6736(05)61513-9"},{"key":"2021120905250607400_R11","doi-asserted-by":"crossref","unstructured":"Biezeveld MH, Kuipers IM, Geissler J, et al. Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease. Lancet.\u20082003;361(9365):1268\u20131270","DOI":"10.1016\/S0140-6736(03)12985-6"},{"key":"2021120905250607400_R12","doi-asserted-by":"crossref","unstructured":"Quasney MW, Bronstein DE, Cantor RM, et al. Increased frequency of alleles associated with elevated tumour necrosis factor-\u03b1 levels in children with Kawasaki disease. Pediatr Res.\u20082001;49(5):686\u2013690","DOI":"10.1203\/00006450-200105000-00013"},{"key":"2021120905250607400_R13","doi-asserted-by":"crossref","unstructured":"Rocha V, Franco RF, Porcher R, et al. Host defence and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation. 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J Am Coll Cardiol.\u20082007;50(12):1115\u20131122","DOI":"10.1016\/j.jacc.2007.06.012"},{"key":"2021120905250607400_R17","doi-asserted-by":"crossref","unstructured":"D'Aiuto F, Casas JP, Shah T, Humphries SE, Hingorani AD, Tonetti MS. C-reactive protein (+1444C\u2192T) polymorphism influences CRP response following a moderate inflammatory stimulus. Atherosclerosis.\u20082005;179(2):413\u2013417","DOI":"10.1016\/j.atherosclerosis.2004.10.036"},{"key":"2021120905250607400_R18","doi-asserted-by":"crossref","unstructured":"Marsik C, Sunder-Plassmann R, Jilma B, et al. The C-reactive protein +1444C\/T alteration modulates the inflammation and coagulation response in human endotoxemia. Clin Chem.\u20082006;52(10):1952\u20131957","DOI":"10.1373\/clinchem.2006.069823"},{"key":"2021120905250607400_R19","doi-asserted-by":"crossref","unstructured":"Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. 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J Pediatr Gastroenterol Nutr.\u20082006;42(5):479\u2013487","DOI":"10.1097\/01.mpg.0000221917.80887.9e"},{"key":"2021120905250607400_R41","doi-asserted-by":"crossref","unstructured":"Kamizono S, Yamada A, Higuchi T, Kato H, Itoh K. Analysis of tumour necrosis factor-\u03b1 production and polymorphisms of the tumour necrosis factor-\u03b1 gene in individuals with a history of Kawasaki disease. Pediatr Int.\u20081999;41(4):341\u2013345","DOI":"10.1046\/j.1442-200x.1999.01085.x"},{"key":"2021120905250607400_R42","unstructured":"Chien YH, Chang KW, Yang YH, Lu MY, Lin YT, Chiang BL. Association between levels of TNF-alpha and TNF-alpha promoter \u2212308 A\/A polymorphism in children with Kawasaki disease. J Formos Med Assoc.\u20082003;102(3):147\u2013150"},{"key":"2021120905250607400_R43","doi-asserted-by":"crossref","unstructured":"Skoog T, Dichtl W, Boquist S, et al. Plasma tumour necrosis factor-\u03b1 and early carotid atherosclerosis in healthy middle-aged men. 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