{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:58:56Z","timestamp":1772254736503,"version":"3.50.1"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:p>OBJECTIVE. The purpose of this prospective study was to assess the feasibility and reliability of pulse oximetry screening to detect critical congenital heart defects in a newborn nursery.<\/jats:p><jats:p>METHODS. The study was performed in a large urban hospital with an exclusively inborn population. Stable neonates who had a gestational age of \u226535 weeks and birth weight of \u22652100 g and in whom a critical congenital heart defect was not suspected were admitted to the newborn nursery. When the 4-hour pulse oximetry reading was &amp;lt;96%, pulse oximetry was repeated at discharge, and when the pulse oximetry reading remained at persistently &amp;lt;96%, echocardiography was performed.<\/jats:p><jats:p>RESULTS. Of 15299 admissions to newborn nursery during the 12-month study period, 15233 (99.6%) neonates were screened with 4-hour pulse oximetry. Pulse oximetry readings were \u226596% for 14374 (94.4%) neonates; 77 were subsequently evaluated before discharge for cardiac defects on the basis of clinical examination. Seventy-six were normal, and 1 had tetralogy of Fallot with discontinuous pulmonary arteries. Pulse oximetry readings at 4 hours were &amp;lt;96% in 859 (5.6%); 768 were rescreened at discharge, and 767 neonates had a pulse oximetry reading at \u226596%. One neonate had persistently low pulse oximetry at discharge; echocardiography was normal. Although 3 neonates with a critical congenital heart defect had a 4-hour pulse oximetry reading of &amp;lt;96%, all developed signs and\/or symptoms of a cardiac defect and received a diagnosis on the basis of clinical findings, not screening results.<\/jats:p><jats:p>CONCLUSIONS. All neonates with a critical congenital heart defect were detected clinically, and no cases of critical congenital heart defect were detected by pulse oximetry screening. These results indicate that pulse oximetry screening does not improve detection of critical congenital heart defects above and beyond clinical observation and assessment. Our findings do not support a recommendation for routine pulse oximetry screening in seemingly healthy neonates.<\/jats:p>","DOI":"10.1542\/peds.2008-0781","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T00:24:58Z","timestamp":1220315098000},"page":"e815-e820","source":"Crossref","is-referenced-by-count":46,"title":["Pulse Oximetry Screening at 4 Hours of Age to Detect Critical Congenital Heart Defects"],"prefix":"10.1542","volume":"122","author":[{"given":"Dorothy M.","family":"Sendelbach","sequence":"first","affiliation":[{"name":"Divisions of Neonatal-Perinatal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Divisions of Neonatal-Perinatal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna S.","family":"Lai","sequence":"additional","affiliation":[{"name":"Divisions of Neonatal-Perinatal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Fixler","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth K.","family":"Stehel","sequence":"additional","affiliation":[{"name":"Divisions of Neonatal-Perinatal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Engle","sequence":"additional","affiliation":[{"name":"Divisions of Neonatal-Perinatal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"2021120902332508800_R1","doi-asserted-by":"crossref","unstructured":"Fixler DE, Pastor P, Chamberlin M, Sigman E. Eifler CW. Trends in congenital heart disease in Dallas County births 1971\u20131984. Circulation.\u20081990;81(1):137\u2013142","DOI":"10.1161\/01.CIR.81.1.137"},{"key":"2021120902332508800_R2","doi-asserted-by":"crossref","unstructured":"Mitchell SC, Korones SB, Berendes HW. Congenital heart disease in 56,109 births: incidence and natural history. Circulation.\u20081971;43(3):323\u2013332","DOI":"10.1161\/01.CIR.43.3.323"},{"key":"2021120902332508800_R3","doi-asserted-by":"crossref","unstructured":"Fernandez CO, Ramaciotti C, Martin LB, Twickler DM. The four-chamber view and its sensitivity in detecting congenital heart defects. Cardiology.\u20081998;90(3):202\u2013206","DOI":"10.1159\/000006844"},{"key":"2021120902332508800_R4","doi-asserted-by":"crossref","unstructured":"Wren C, Richmond S, Donaldson L. Presentation of congenital heart disease in infancy: implications for routine examination. Arch Dis Child Fetal Neonatal Ed.\u20081999;80(1):F49\u2013F53","DOI":"10.1136\/fn.80.1.F49"},{"key":"2021120902332508800_R5","doi-asserted-by":"crossref","unstructured":"Knowles R, Griebsch I, Dezateux C, Brown J, Bull C, Wren C. Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis. Health Technol Assess.\u20082005;9(44):1\u2013292","DOI":"10.3310\/hta9440"},{"key":"2021120902332508800_R6","doi-asserted-by":"crossref","unstructured":"Reich JD, Miller S, Brogdon B, et al. The use of pulse oximetry to detect congenital heart disease. J Pediatr.\u20082003;142(3):268\u2013272","DOI":"10.1067\/mpd.2003.87"},{"key":"2021120902332508800_R7","doi-asserted-by":"crossref","unstructured":"Koppel RI, Druschel CM, Carter T, et al. Effectiveness of pulse oximetry screening for congenital heart disease in asymptomatic newborns. Pediatrics.\u20082003;111(3):451\u2013455","DOI":"10.1542\/peds.111.3.451"},{"key":"2021120902332508800_R8","doi-asserted-by":"crossref","unstructured":"Hoke TR, Donohue PK, Bawa PK, et al. Oxygen saturation as a screening test for critical congenital heart disease: a preliminary study. Pediatr Cardiol.\u20082002;23(4):403\u2013409","DOI":"10.1007\/s00246-002-1482-8"},{"key":"2021120902332508800_R9","doi-asserted-by":"crossref","unstructured":"Richmond S, Reay G, Harb MA. Routine pulse oximetry in the asymptomatic newborn. Arch Dis Child Fetal Neonatal Ed.\u20082002;87(2):F83\u2013F88","DOI":"10.1136\/fn.87.2.F83"},{"key":"2021120902332508800_R10","doi-asserted-by":"crossref","unstructured":"Rosati E, Chitano G, Dipaola L, DeFelice C, Latini G. Indications and limitations for a neonatal pulse oximetry screening of critical congenital heart disease. J Perinat Med.\u20082005;33(5):455\u2013457","DOI":"10.1515\/JPM.2005.080"},{"key":"2021120902332508800_R11","doi-asserted-by":"crossref","unstructured":"Bakr AF, Habib HS. Combining pulse oximetry and clinical examination in screening for congenital heart disease. Pediatr Cardiol.\u20082005;26(6):832\u2013835","DOI":"10.1007\/s00246-005-0981-9"},{"key":"2021120902332508800_R12","doi-asserted-by":"crossref","unstructured":"Arlettaz R, Bauschatz AS, Mo\u0308nkhoff M, Essers B, Bauersfeld U. The contribution of pulse oximetry to the early detection of congenital heart disease in newborns. Eur J Pediatr.\u20082006;165(2):94\u201398","DOI":"10.1007\/s00431-005-0006-y"},{"key":"2021120902332508800_R13","doi-asserted-by":"crossref","unstructured":"de Wahl Granelli A, Mellander M, Sunnega\u030ardh J, Sandberg K, O\u0303stman-Smith I. Screening for duct-dependent congenital heart disease with pulse oximetry: a critical evaluation of strategies to maximize sensitivity. Acta Paediatr.\u20082005;94(11):1590\u20131596","DOI":"10.1111\/j.1651-2227.2005.tb01834.x"},{"key":"2021120902332508800_R14","unstructured":"Gnanalingham MG, Mehta BM, Siverajan M, et al. Pulse oximetry as a screening test in neonates [abstract]. Arch Dis Child.\u20082001;84(suppl 1):A35"},{"key":"2021120902332508800_R15","unstructured":"Saving Little Hearts. Helping children with congenital heart defects. Available at: www.savinglittlehearts.com\/index.php. Accessed February 1, 2008"},{"key":"2021120902332508800_R16","doi-asserted-by":"crossref","unstructured":"Thangaratinam S, Daniels J, Ewer AK, Zamora J, Khan KS. Accuracy of pulse oximetry in screening for congenital heart disease in asymptomatic newborns: a systematic review. Arch Dis Child Fetal Neonatal Ed.\u20082007;92(3):F176\u2013F180","DOI":"10.1136\/adc.2006.107656"},{"key":"2021120902332508800_R17","doi-asserted-by":"crossref","unstructured":"Valmari P. Should pulse oximetry be used to screen for congenital heart disease?Arch Dis Child Fetal Neonatal Ed.\u20082007;92(3):F219\u2013F224","DOI":"10.1136\/adc.2005.090282"},{"key":"2021120902332508800_R18","doi-asserted-by":"crossref","unstructured":"Aamir T, Kruse L, Ezeakudo O. Delayed diagnosis of critical congenital cardiovascular malformations (CCVM) and pulse oximetry screening of newborns. Acta Paediatr.\u20082007;96(8):1146\u20131149","DOI":"10.1111\/j.1651-2227.2007.00389.x"},{"key":"2021120902332508800_R19","doi-asserted-by":"crossref","unstructured":"Liske MR, Greeley CS, Law DJ, et al. Report of the Tennessee Task Force on Screening Newborn Infants for Critical Congenital Heart Disease. Pediatrics.\u20082006;118(4). Available at(4): www.pediatrics.org\/cgi\/content\/full\/118\/4\/e1250","DOI":"10.1542\/peds.2005-3061"},{"key":"2021120902332508800_R20","unstructured":"American Academy of Pediatrics; College of Obstetricians and Gynecologists. Guidelines for Perinatal Care. 6th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2007:218"},{"key":"2021120902332508800_R21","doi-asserted-by":"crossref","unstructured":"Levesque BM, Pollack P, Griffin BE. Pulse oximetry: what's normal in the newborn nursery?Pediatr Pulmonol.\u20082000;30(5):406\u2013412","DOI":"10.1002\/1099-0496(200011)30:5<406::AID-PPUL7>3.0.CO;2-C"},{"key":"2021120902332508800_R22","doi-asserted-by":"crossref","unstructured":"Reddy VK, Holman IR, Wedgwood JF. Pulse oximetry saturations in the first 6 hours of life in normal term infants. Clin Pediatr (Phila).\u20081999;38(2):87\u201392","DOI":"10.1177\/000992289903800204"},{"key":"2021120902332508800_R23","doi-asserted-by":"crossref","unstructured":"Kemper K, Forsyth B, McCarthy P. Jaundice, terminating breast-feeding, and the vulnerable child. Pediatrics.\u20081989;84(5):773\u2013778","DOI":"10.1542\/peds.84.5.773"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/122\/4\/e815\/1123126\/zpe0100800e815.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/122\/4\/e815\/1123126\/zpe0100800e815.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T20:38:23Z","timestamp":1684528703000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/122\/4\/e815\/71340\/Pulse-Oximetry-Screening-at-4-Hours-of-Age-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,1]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,10,1]]},"published-print":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2008-0781","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,1]]}}}