{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:35:17Z","timestamp":1792658117304,"version":"4.5.0"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>OBJECTIVE: The aim of this study was to define the association between age and the occurrence of acute pyelonephritis and renal scars.<\/jats:p>\n               <jats:p>METHODS: Between 1999 and 2002, all children 0 to 14 years of age consecutively seen with a first febrile urinary tract infection were enrolled in the study. 99mTc-Dimercaptosuccinic acid renal scintigraphy was performed within 5 days after admission for the detection of renal parenchymal involvement. The presence of vesicoureteral reflux was assessed by using cystography performed 1 month after the infection. If the acute scan results were abnormal, then follow-up 99mTc-dimercaptosuccinic acid scanning was performed after 6 months, to assess the frequency of scars.<\/jats:p>\n               <jats:p>RESULTS: A total of 316 children were enrolled in the study (190 children &amp;lt;1 year, 99 children 1\u20134 years, and 27 children 5\u201314 years of age). 99mTc-Dimercaptosuccinic acid scintigraphy revealed that 59% of the children had renal involvement in the acute phase of infection. The frequency of kidney involvement in infants &amp;lt;1 year of age (49%) was significantly lower than that in children 1 to 4 years of age (73%) and &amp;gt;5 years of age (81%). Of the 187 children with positive acute 99mTc-dimercaptosuccinic acid scan results, 123 underwent repeat scintigraphy after 6 months. Renal scars were found for 28% of children &amp;lt;1 year, 37% of children 1 to 4 years, and 53% of children 5 to 14 years of age. No significant differences in the frequency of scars and the presence or absence of vesicoureteral reflux were noted.<\/jats:p>\n               <jats:p>CONCLUSIONS: Our findings confirm that acute pyelonephritis and subsequent renal scarring occur only in some children with first febrile urinary tract infections. Children &amp;lt;1 year of age with febrile urinary tract infections have a lower risk of parenchymal localization of infection and renal scarring.<\/jats:p>","DOI":"10.1542\/peds.2008-1192","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T15:18:44Z","timestamp":1246288724000},"page":"23-29","source":"Crossref","is-referenced-by-count":51,"title":["Age-Related Renal Parenchymal Lesions in Children With First Febrile Urinary Tract Infections"],"prefix":"10.1542","volume":"124","author":[{"given":"Paolo","family":"Pecile","sequence":"first","affiliation":[{"name":"Department of Pediatrics, DPMSC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Miorin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, DPMSC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Romanello","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, DPMSC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, DPMSC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Contardo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, DPMSC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Valent","sequence":"additional","affiliation":[{"name":"Institute of Hygiene and Epidemiology, University of Udine, School of Medicine, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Tenore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, DPMSC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"2021120902483375400_R1","doi-asserted-by":"crossref","unstructured":"Hellerstein S. 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