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The currently recommended follow-up procedures (repeated urine cultures, renal and genitourinary imaging, antimicrobial therapy and prophylaxis, as well as other factors including cleanliness, adequate bladder and bowel emptying, and compliance with protocols) are expensive (in terms of time, attention to detail, and cost) and cumbersome. Such recommendations should be evidence-based.<\/jats:p>","DOI":"10.1542\/peds.2008-1285c","type":"journal-article","created":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T20:47:43Z","timestamp":1227041263000},"page":"S233-S239","source":"Crossref","is-referenced-by-count":48,"title":["Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): Background Commentary of RIVUR Investigators"],"prefix":"10.1542","volume":"122","author":[{"given":"Russell W.","family":"Chesney","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myra A.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marva","family":"Moxey-Mims","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leroy","family":"Nyberg","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saul P.","family":"Greenfield","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology, Children's Hospital, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Hoberman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Urology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tej K.","family":"Matoo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"members of the RIVUR Steering Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"2021120821150991100_R1","doi-asserted-by":"crossref","unstructured":"Beetz R. 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