{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:55Z","timestamp":1788959815006,"version":"build-2803163510"},"reference-count":52,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:p>BACKGROUND: Synchronized nasal intermittent positive-pressure ventilation (SNIPPV) use reduces reintubation rates compared with nasal continuous positive airway pressure (NCPAP). Limited information is available on the outcomes of infants managed with SNIPPV.<\/jats:p><jats:p>OBJECTIVES: To compare the outcomes of infants managed with SNIPPV (postextubation or for apnea) to infants not treated with SNIPPV at 2 sites.<\/jats:p><jats:p>METHODS: Clinical retrospective data was used to evaluate the use of SNIPPV in infants \u22641250 g birth weight (BW); and 3 BW subgroups (500\u2013750, 751\u20131000, and 1001\u20131250 g, decided a priori). SNIPPV was not assigned randomly. Bronchopulmonary dysplasia (BPD) was defined as treatment with supplemental oxygen at 36 weeks' postmenstrual age.<\/jats:p><jats:p>RESULTS: Overall, infants who were treated with SNIPPV had significantly lower mean BW (863 vs 964 g) and gestational age (26.4 vs 27.9 weeks), more frequently received surfactant (85% vs 68%), and had a higher incidence of BPD or death (39% vs 27%) (all P &amp;lt; .01) compared with infants treated with NCPAP. In the subgroup analysis, SNIPPV was associated with lower rates of BPD (43% vs 67%; P = .03) and BPD\/death (51% vs 76%; P = .02) in the 500- to 750-g infants, with no significant differences in the other BW groups. Logistic regression analysis, adjusting for significant covariates, revealed infants with 500\u2013700-g BW who received SNIPPV were significantly less likely to have the outcomes of BPD (OR: 0.29 [95% CI: 0.11\u20130.77]; P = .01), BPD\/death (OR: 0.30 [95% CI: 0.11\u20130.79]; P = .01), neurodevelopmental impairment (NDI) (OR: 0.29 [95% CI: 0.09\u20130.94]; P = .04), and NDI\/death (OR: 0.18 [95% CI: 0.05\u20130.62]; P = .006).<\/jats:p><jats:p>CONCLUSION: SNIPPV use in infants at greatest risk of BPD or death (500\u2013750 g) was associated with decreased BPD, BPD\/death, NDI, and NDI\/death when compared with infants managed with NCPAP.<\/jats:p>","DOI":"10.1542\/peds.2008-1302","type":"journal-article","created":{"date-parts":[[2009,7,27]],"date-time":"2009-07-27T11:32:55Z","timestamp":1248694375000},"page":"517-526","source":"Crossref","is-referenced-by-count":70,"title":["Synchronized Nasal Intermittent Positive-Pressure Ventilation and Neonatal Outcomes"],"prefix":"10.1542","volume":"124","author":[{"given":"Vineet","family":"Bhandari","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil N.","family":"Finer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Ehrenkranz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shampa","family":"Saha","sequence":"additional","affiliation":[{"name":"Research Triangle Institute, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[{"name":"Research Triangle Institute, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Engle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Riley Hospital for Children, Indiana University, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisa P.","family":"VanMeurs","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2021120905305758100_R1","unstructured":"Mathews TJ, MacDorman MF. 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