{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:53:54Z","timestamp":1793159634840,"version":"4.5.0"},"reference-count":42,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>OBJECTIVE. Extremely preterm infants are at risk for poor growth and impaired neurodevelopment. The objective of this study was to determine whether intrauterine, early neonatal, or postdischarge growth is associated with neurocognitive and motor-developmental outcome in extremely preterm infants.<\/jats:p>\n                  <jats:p>METHODS. Surviving children who were born between July 1996 and June 1999 at &amp;lt;30 weeks' gestation and with a birth weight &amp;lt;1500 g were evaluated at the age of school entry by application of (1) a standardized neurologic evaluation, (2) the Kaufmann Assessment Battery for Children, and (3) the Gross Motor Function Classification Scale. Growth was assessed on the basis of SD scores of weight and head circumference measured at birth, at discharge, and at the time of the follow-up examination. All infants had received intensive early nutritional support.<\/jats:p>\n                  <jats:p>RESULTS. A total of 219 (83%) of 263 long-term survivors were evaluated at a median corrected age of 5.4 years. Increasing SD scores for weight and head circumference from birth to discharge were associated with a reduced risk for an abnormal neurologic examination. Catch-up growth of head circumference from birth to discharge was also associated with a reduced risk for impaired mobility. Weight SD score at birth, an increase of weight SD score from birth to discharge, and an increase of head circumference SD score from discharge to follow-up had an effect on the mental processing composite score. The effects of growth on neurodevelopment were by far exceeded by the consequences of intraventricular and periventricular hemorrhage.<\/jats:p>\n                  <jats:p>CONCLUSIONS. Growth from birth to discharge seemed to be associated with long-term motor development. Cognitive development was associated with intrauterine growth measured as weight at birth, early neonatal weight gain, and postdischarge head circumference growth. Improving particularly early neonatal growth may improve long-term outcome in extremely preterm infants, but the effects of improved growth may only be small.<\/jats:p>","DOI":"10.1542\/peds.2008-1352","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T10:58:03Z","timestamp":1230548283000},"page":"e101-e109","source":"Crossref","is-referenced-by-count":379,"title":["Intrauterine, Early Neonatal, and Postdischarge Growth and Neurodevelopmental Outcome at 5.4 Years in Extremely Preterm Infants After Intensive Neonatal Nutritional Support"],"prefix":"10.1542","volume":"123","author":[{"given":"Axel R.","family":"Franz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Pediatric Critical Care"},{"name":"Center for Pediatrics, Department of Neonatology, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Pohlandt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Pediatric Critical Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Bode","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Mihatsch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Pediatric Critical Care"},{"name":"Department of Pediatrics, Children's Hospital, Schwaebisch Hall, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sander","sequence":"additional","affiliation":[{"name":"Institute of Biometrics, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kron","sequence":"additional","affiliation":[{"name":"Institute of Biometrics, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Steinmacher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Pediatric Critical Care"},{"name":"Department of Pediatrics, Division of Pediatric Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"2021120905094091800_R1","doi-asserted-by":"crossref","unstructured":"Ehrenkranz RA, Younes N, Lemons JA, et al. Longitudinal growth of hospitalized very low birth weight infants. Pediatrics.\u20081999;104(2 pt 1):280\u2013289","DOI":"10.1542\/peds.104.2.280"},{"key":"2021120905094091800_R2","doi-asserted-by":"crossref","unstructured":"Dusick AM, Poindexter BB, Ehrenkranz RA, Lemons JA. Growth failure in the preterm infant: can we catch up?Semin Perinatol.\u20082003;27(4):302\u2013310","DOI":"10.1016\/S0146-0005(03)00044-2"},{"key":"2021120905094091800_R3","doi-asserted-by":"crossref","unstructured":"Clark RH, Thomas P, Peabody J. Extrauterine growth restriction remains a serious problem in prematurely born neonates. Pediatrics.\u20082003;111(5 pt 1):986\u2013990","DOI":"10.1542\/peds.111.5.986"},{"key":"2021120905094091800_R4","doi-asserted-by":"crossref","unstructured":"Hack M, Schluchter M, Cartar L, Rahman M, Cuttler L, Borawski E. Growth of very low birth weight infants to age 20 years. Pediatrics.\u20082003;112(1). Available at: www.pediatrics.org\/cgi\/content\/full\/112\/1\/e30","DOI":"10.1542\/peds.112.1.e30"},{"key":"2021120905094091800_R5","doi-asserted-by":"crossref","unstructured":"Cooke RJ, Ainsworth SB, Fenton AC. Postnatal growth retardation: a universal problem in preterm infants. Arch Dis Child Fetal Neonatal Ed.\u20082004;89(5):F428\u2013F430","DOI":"10.1136\/adc.2001.004044"},{"key":"2021120905094091800_R6","doi-asserted-by":"crossref","unstructured":"Hack M, Taylor HG, Klein N, Eiben R, Schatschneider C, Mercuri Minich N. School-age outcomes in children with birth weights under 750 g. N Engl J Med.\u20081994;331(12):753\u2013759","DOI":"10.1056\/NEJM199409223311201"},{"key":"2021120905094091800_R7","doi-asserted-by":"crossref","unstructured":"Wolke D, Meyer R. Cognitive status, language attainment, and prereading skills of 6-year-old very preterm children and their peers: the Bavarian Longitudinal Study. 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