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The characteristics of children presenting with nephrotic syndrome have changed over recent decades with greater frequency of the challenging condition focal segmental glomerulosclerosis and a greater prevalence of obesity and diabetes mellitus, which may be resistant to glucocorticoids in the former and exacerbated by long-term glucocorticoid therapy in the latter 2 conditions. The Children's Nephrotic Syndrome Consensus Conference was formed to systematically review the published literature and generate a children's primary nephrotic syndrome guideline for use in educational, therapeutic, and research venues.<\/jats:p>","DOI":"10.1542\/peds.2008-1559","type":"journal-article","created":{"date-parts":[[2009,7,27]],"date-time":"2009-07-27T07:32:55Z","timestamp":1248679975000},"page":"747-757","source":"Crossref","is-referenced-by-count":236,"title":["Management of Childhood Onset Nephrotic Syndrome"],"prefix":"10.1542","volume":"124","author":[{"given":"Debbie S.","family":"Gipson","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine and Pediatrics, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan F.","family":"Massengill","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Levine Children's Hospital at Carolinas Medical Center, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Inova Fairfax Hospital for Children, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Wake Forest University Medical Center, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Smoyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, University of Michigan, Ann Arbor, Michigan"},{"name":"Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Mahan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delbert","family":"Wigfall","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Miles","sequence":"additional","affiliation":[{"name":"American Board of Pediatrics, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine and Pediatrics, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Jar","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Wake Forest University Medical Center, Winston-Salem, North Carolina"},{"name":"Department of Pediatric Nephrology, East Carolina University, Greenville, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Trachtman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Schneider Children's Hospital, New Hyde Park, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2021120905284093100_R1","doi-asserted-by":"crossref","unstructured":"Churg J, Habib R, White RH. 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