{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:06:59Z","timestamp":1791058019791,"version":"4.1.0"},"reference-count":29,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>OBJECTIVE. We tested the hypothesis that soluble vascular endothelial growth factor receptors are involved in the development of bronchopulmonary dysplasia\/chronic lung disease.<\/jats:p>\n               <jats:p>PATIENTS AND METHODS. Neonates with a birth weight of \u22641500 g and\/or \u226430 weeks\u2019 gestation, with respiratory failure, requiring O2 and mechanical ventilation within 24 hours, were eligible. Tracheal aspirate fluid samples were collected from 65 neonates before surfactant and\/or assisted mechanical ventilation (baseline), at 3 and 7 days after birth, and weekly thereafter until extubation. Samples were analyzed for total vascular endothelial growth factor, soluble vascular endothelial growth factor receptor 1 and 2 levels and compared in infants with bronchopulmonary dysplasia\/chronic lung disease (n = 31) versus those with no bronchopulmonary dysplasia\/chronic lung disease (n = 34).<\/jats:p>\n               <jats:p>RESULTS. Mean gestational age and birth weight were lower in infants with bronchopulmonary dysplasia\/chronic lung disease. At baseline, vascular endothelial growth factor levels in the tracheal aspirate fluid were significantly lower, whereas soluble vascular endothelial growth factor receptor 1 levels were higher in the bronchopulmonary dysplasia\/chronic lung disease infants compared with infants with no bronchopulmonary dysplasia\/chronic lung disease. Vascular endothelial growth factor levels progressively increased from baseline to 4 weeks in all of the infants developing bronchopulmonary dysplasia\/chronic lung disease. Conversely, soluble vascular endothelial growth factor receptor 1 declined in both groups from baseline to 5 weeks of age. Similarly, soluble vascular endothelial growth factor receptor 2 declined from baseline to 5 weeks in the control infants, but there were significant increases at 3 and 4 weeks in infants developing bronchopulmonary dysplasia\/chronic lung disease.<\/jats:p>\n               <jats:p>CONCLUSIONS. We speculate that low vascular endothelial growth factor levels in tracheal aspirate fluid, concurrent with elevated soluble vascular endothelial growth factor receptor 1 levels on the first day of life, are biological markers for the development of bronchopulmonary dysplasia\/chronic lung disease in very low birth weight infants requiring O2 and assisted mechanical ventilation.<\/jats:p>","DOI":"10.1542\/peds.2008-1670","type":"journal-article","created":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T11:28:01Z","timestamp":1243337281000},"page":"1541-1547","source":"Crossref","is-referenced-by-count":33,"title":["Soluble Vascular Endothelial Growth Factor Receptor 1 in Tracheal Aspirate Fluid of Preterm Neonates at Birth May Be Predictive of Bronchopulmonary Dysplasia\/Chronic Lung Disease"],"prefix":"10.1542","volume":"123","author":[{"given":"Jamal","family":"Hasan","sequence":"first","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, Irvine, California"},{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Miller Children's Hospital, Long Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay D.","family":"Beharry","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, Irvine, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwin M.","family":"Valencia","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Miller Children's Hospital, Long Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Strauss","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Miller Children's Hospital, Long Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houchang D.","family":"Modanlou","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, Irvine, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"2021120902432741500_R1","doi-asserted-by":"crossref","unstructured":"Ehrenkranz RA, Walsh MC, Vohr BR, et al. 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