{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:24:33Z","timestamp":1783481073991,"version":"3.55.0"},"reference-count":52,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>OBJECTIVES: Cerebral pressure passivity is common in sick premature infants and may predispose to germinal matrix\/intraventricular hemorrhage (GM\/IVH), a lesion with potentially serious consequences. We studied the association between the magnitude of cerebral pressure passivity and GM\/IVH.<\/jats:p>\n               <jats:p>PATIENTS AND METHODS: We enrolled infants &amp;lt;32 weeks' gestational age with indwelling mean arterial pressure (MAP) monitoring and excluded infants with known congenital syndromes or antenatal brain injury. We recorded continuous MAP and cerebral near-infrared spectroscopy hemoglobin difference (HbD) signals at 2 Hz for up to 12 hours\/day and up to 5 days. Coherence and transfer function analysis between MAP and HbD signals was performed in 3 frequency bands (0.05\u20130.25, 0.25\u20130.5, and 0.5\u20131.0 Hz). Using MAP-HbD gain and clinical variables (including chorioamnionitis, Apgar scores, gestational age, birth weight, neonatal sepsis, and Score for Neonatal Acute Physiology II), we built a logistic regression model that best predicts cranial ultrasound abnormalities.<\/jats:p>\n               <jats:p>RESULTS: In 88 infants (median gestational age: 26 weeks [range 23\u201330 weeks]), early cranial ultrasound showed GM\/IVH in 31 (37%) and parenchymal echodensities in 10 (12%) infants; late cranial ultrasound showed parenchymal abnormalities in 19 (30%) infants. Low-frequency MAP-HbD gain (highest quartile mean) was significantly associated with early GM\/IVH but not other ultrasound findings. The most parsimonious model associated with early GM\/IVH included only gestational age and MAP-HbD gain.<\/jats:p>\n               <jats:p>CONCLUSIONS: This novel cerebrovascular monitoring technique allows quantification of cerebral pressure passivity as MAP-HbD gain in premature infants. High MAP-HbD gain is significantly associated with GM\/IVH. Precise temporal and causal relationship between MAP-HbD gain and GM\/IVH awaits further study.<\/jats:p>","DOI":"10.1542\/peds.2008-2004","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T15:18:44Z","timestamp":1246288724000},"page":"302-309","source":"Crossref","is-referenced-by-count":136,"title":["Elevated Cerebral Pressure Passivity Is Associated With Prematurity-Related Intracranial Hemorrhage"],"prefix":"10.1542","volume":"124","author":[{"given":"Heather","family":"O'Leary","sequence":"first","affiliation":[{"name":"Fetal-Neonatal Neurology Research Group, Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Gregas","sequence":"additional","affiliation":[{"name":"Clinical Research Program, and Children's Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Limperopoulos","sequence":"additional","affiliation":[{"name":"Fetal-Neonatal Neurology Research Group, Department of Neurology"},{"name":"Department of Neurology and Neurosurgery and School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Zaretskaya","sequence":"additional","affiliation":[{"name":"Fetal-Neonatal Neurology Research Group, Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Bassan","sequence":"additional","affiliation":[{"name":"Fetal-Neonatal Neurology Research Group, Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Soul","sequence":"additional","affiliation":[{"name":"Fetal-Neonatal Neurology Research Group, Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald N.","family":"Di Salvo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adre\u0301 J.","family":"du Plessis","sequence":"additional","affiliation":[{"name":"Fetal-Neonatal Neurology Research Group, Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"2021120902464188500_R1","doi-asserted-by":"crossref","unstructured":"Sheth RD. 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