{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:44:25Z","timestamp":1787921065617,"version":"build-2784847793"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>OBJECTIVES. Acute intravascular hemolysis after exchange transfusion with glucose 6-phosphate dehydrogenase\u2013deficient blood has been reported; however, it is not routine to screen donor blood for glucose 6-phosphate dehydrogenase deficiency while performing exchange transfusion. We hypothesized that exchange transfusion with glucose 6-phosphate dehydrogenase\u2013deficient blood would lead to a less-than-expected decrease in total serum bilirubin. The objective of this study was to evaluate the effect of exchange transfusion with glucose 6-phosphate dehydrogenase\u2013deficient blood in neonates with idiopathic hyperbilirubinemia on postexchange total serum bilirubin levels, duration of phototherapy, and need for repeat exchange transfusions.<\/jats:p>\n               <jats:p>METHODS. All neonates who were undergoing exchange transfusion for idiopathic hyperbilirubinemia were enrolled. A sample of donor blood was collected at the time of exchange transfusion for a glucose 6-phosphate dehydrogenase assay. The standard criteria for starting and stopping phototherapy and exchange transfusion were applied.<\/jats:p>\n               <jats:p>RESULTS. During the 1-year study period, 21 infants underwent exchange with glucose 6-phosphate dehydrogenase\u2013deficient blood, and 114 neonates with similar baseline characteristics underwent exchange transfusion with glucose 6-phosphate dehydrogenase\u2013normal blood. From 6 to 60 hours after exchange transfusion, there was a significantly lesser drop in total serum bilirubin in the recipients of glucose 6-phosphate dehydrogenase\u2013deficient donor blood compared with recipients of glucose 6-phosphate dehydrogenase\u2013normal blood. The mean duration of phototherapy in the postexchange period and number of infants who underwent repeat exchange transfusions were significantly higher in recipients of glucose 6-phosphate dehydrogenase\u2013deficient donor blood in comparison with control subjects. Concurrently, there was a significantly higher drop in hematocrit and rise in plasma hemoglobin in the glucose 6-phosphate dehydrogenase\u2013deficient donor group.<\/jats:p>\n               <jats:p>CONCLUSIONS. Exchange transfusion with glucose 6-phosphate dehydrogenase\u2013deficient donor blood leads to a lesser drop in postexchange total serum bilirubin. It prolongs the duration of phototherapy and increases the need for repeat exchange transfusions.<\/jats:p>","DOI":"10.1542\/peds.2008-2021","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T01:34:02Z","timestamp":1229996042000},"page":"e96-e100","source":"Crossref","is-referenced-by-count":28,"title":["Donor Blood Glucose 6-Phosphate Dehydrogenase Deficiency Reduces the Efficacy of Exchange Transfusion in Neonatal Hyperbilirubinemia"],"prefix":"10.1542","volume":"123","author":[{"given":"Sandip","family":"Samanta","sequence":"first","affiliation":[{"name":"Neonatal Unit, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Sunil","family":"Kishore","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjeewan","family":"Garewal","sequence":"additional","affiliation":[{"name":"Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Narang","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"2021120905105615500_R1","doi-asserted-by":"crossref","unstructured":"Wolfe LC. 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