{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:44:54Z","timestamp":1793382294020,"version":"4.5.0"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>Objective. The goal was to examine the demographic characteristics, causative foods, clinical features, treatments, and outcomes for children presenting with acute food protein-induced enterocolitis syndrome.<\/jats:p>\n                  <jats:p>Methods. This was a retrospective study of children with food protein-induced enterocolitis syndrome who presented to the Children's Hospital at Westmead (Sydney, Australia) over 16 years.<\/jats:p>\n                  <jats:p>Results. Thirty-five children experienced 66 episodes of food protein-induced enterocolitis syndrome. The mean age at initial presentation was 5.5 months. Children frequently experienced multiple episodes before a correct diagnosis was made. Twenty-nine children reacted to 1 food, and 6 reacted to 2 foods. Causative foods for the 35 children were rice (n = 14), soy (n = 12), cow's milk (n = 7), vegetables and fruits (n = 3), meats (n = 2), oats (n = 2), and fish (n = 1). In the 66 episodes, vomiting was the most common clinical feature (100%), followed by lethargy (85%), pallor (67%), and diarrhea (24%). A temperature of &amp;lt;36\u00b0C at presentation was recorded for 24% of episodes. A platelet count of &amp;gt;500 \u00d7 109 cells per L was recorded for 63% of episodes with blood count results. Only 2 of the 19 children who presented to an emergency department with their initial reactions were discharged with correct diagnoses. Additional investigations of food protein-induced enterocolitis syndrome episodes presenting to the hospital were common, with 34% of patients undergoing abdominal imaging, 28% undergoing a septic evaluation, and 22% having a surgical consultation. Prognosis was good, with high rates of resolution for the 2 most common food triggers (ie, rice and soy) by 3 years of age.<\/jats:p>\n                  <jats:p>Conclusions. Misdiagnosis and delays in diagnosis for children with food protein-induced enterocolitis syndrome were common, leading many children to undergo unnecessary, often painful investigations. Decreased body temperature and thrombocytosis emerge as additional features of the syndrome.<\/jats:p>","DOI":"10.1542\/peds.2008-2029","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T20:34:18Z","timestamp":1233606858000},"page":"e459-e464","source":"Crossref","is-referenced-by-count":243,"title":["Food Protein-Induced Enterocolitis Syndrome: 16-Year Experience"],"prefix":"10.1542","volume":"123","author":[{"given":"Sam","family":"Mehr","sequence":"first","affiliation":[{"name":"Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, Australia"},{"name":"Discipline of Paediatrics and Child Health, Clinical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Kakakios","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Frith","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics and Child Health, Clinical School, University of Sydney, Sydney, Australia"},{"name":"Australian Paediatric Surveillance Unit, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, Australia"},{"name":"Discipline of Paediatrics and Child Health, Clinical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2021120902454322900_R1","doi-asserted-by":"crossref","unstructured":"Gray HC, Foy TM, Becker BA, Knutsen AP. 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