{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:00:57Z","timestamp":1768622457972,"version":"3.49.0"},"reference-count":43,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:p>OBJECTIVE: The aim of this study was to devise a scoring system that could aid in predicting neurologic outcome at the onset of neonatal seizures.<\/jats:p>\n               <jats:p>METHODS: A total of 106 newborns who had neonatal seizures and were consecutively admitted to the NICU of the University of Parma from January 1999 through December 2004 were prospectively followed-up, and neurologic outcome was assessed at 24 months\u2019 postconceptional age. We conducted a retrospective analysis on this cohort to identify variables that were significantly related to adverse outcome and to develop a scoring system that could provide early prognostic indications.<\/jats:p>\n               <jats:p>RESULTS: A total of 70 (66%) of 106 infants had an adverse neurologic outcome. Six variables were identified as the most important independent risk factors for adverse outcome and were used to construct a scoring system: birth weight, Apgar score at 1 minute, neurologic examination at seizure onset, cerebral ultrasound, efficacy of anticonvulsant therapy, and presence of neonatal status epilepticus. Each variable was scored from 0 to 3 to represent the range from \u201cnormal\u201d to \u201cseverely abnormal.\u201d A total composite score was computed by addition of the raw scores of the 6 variables. This score ranged from 0 to 12. A cutoff score of \u22654 provided the greatest sensitivity and specificity.<\/jats:p>\n               <jats:p>CONCLUSIONS: This scoring system may offer an easy, rapid, and reliable prognostic indicator of neurologic outcome after the onset of neonatal seizures. A final assessment of the validity of this score in routine clinical practice will require independent validation in other centers.<\/jats:p>","DOI":"10.1542\/peds.2008-2087","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T00:34:47Z","timestamp":1252974887000},"page":"e580-e587","source":"Crossref","is-referenced-by-count":53,"title":["A Scoring System for Early Prognostic Assessment After Neonatal Seizures"],"prefix":"10.1542","volume":"124","author":[{"given":"Francesco","family":"Pisani","sequence":"first","affiliation":[{"name":"Child Neuropsychiatric Unit, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Sisti","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatric Unit, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Seri","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, Clinical Neurophysiology Unit, Aston University, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"2021120905080060600_R1","doi-asserted-by":"crossref","unstructured":"Holden KR, Mellits ED, Freeman JM. 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