{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:48:57Z","timestamp":1791805737346,"version":"4.3.4"},"reference-count":37,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:p>OBJECTIVES: There are few published data on the efficacy of ibuprofen in the most immature infants and no data on repeated courses. Our objectives were to describe PDA closure rates in a population of infants &amp;lt;1000 g birth weight after repeated courses of ibuprofen, to examine the effect of gestation, and to document plasma markers of renal function and platelet counts.<\/jats:p><jats:p>METHODS: This was a single center observational study. We collected data on infants weighing &amp;lt;1000 g at birth who were treated with ibuprofen for a clinically significant PDA. A successful outcome was defined as resolution of clinical symptoms such that no additional treatment was required. Serum biochemistry and hematology data were analyzed and compared with controls.<\/jats:p><jats:p>RESULTS: We identified 160 infants with a mean \u00b1 SD birth weight of 757 \u00b1 127 g and gestation of 25.6 \u00b1 1.4 weeks. Seventy infants closed their PDA after a single course of ibuprofen (45%) and 32\/80 (40%) following a second. Infants of &amp;lt;26 weeks' gestation (n = 83) were less likely to respond after both the first (27.7% vs 63.6%; P &amp;lt; .001) and second (30.9% vs 60.0%; P = .026) courses. The postnatal decrease in plasma creatinine was delayed by ibuprofen treatment, while platelet counts and other plasma markers were unaffected.<\/jats:p><jats:p>CONCLUSIONS: In our study population, PDA closure was gestation dependant, with a cumulative closure rate of 65%. A similar proportion of infants closed their PDA following the first and second courses regardless of gestation. These data suggest that a second course of ibuprofen may be effective in closing a PDA in even the most preterm infant.<\/jats:p>","DOI":"10.1542\/peds.2008-2232","type":"journal-article","created":{"date-parts":[[2009,7,27]],"date-time":"2009-07-27T11:32:55Z","timestamp":1248694375000},"page":"e287-e293","source":"Crossref","is-referenced-by-count":56,"title":["A Second Course of Ibuprofen Is Effective in the Closure of a Clinically Significant PDA in ELBW Infants"],"prefix":"10.1542","volume":"124","author":[{"given":"Justin","family":"Richards","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Johnson","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grenville","family":"Fox","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morag","family":"Campbell","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2021120905311832600_R1","doi-asserted-by":"crossref","unstructured":"Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR. 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