{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:35:57Z","timestamp":1775666157747,"version":"3.50.1"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:p>OBJECTIVES. The objectives of this study were to determine the impact of different volume-targeted levels on the work of breathing and to investigate whether a level that reduced the work of breathing below that experienced during ventilatory support without volume targeting could be determined.<\/jats:p>\n               <jats:p>METHODS. The transdiaphragmatic pressure-time product, as an estimate of the work of breathing, was measured for 20 infants (median gestational age: 28 weeks) who were being weaned from respiratory support by using patient-triggered ventilation (either assist-control ventilation or synchronous intermittent mandatory ventilation). The transdiaphragmatic pressure-time product was measured first without volume targeting (baseline) and then at volume-targeted levels of 4, 5, and 6 mL\/kg, delivered in random order. After each volume-targeted level, the infants were returned to baseline. Each step was maintained for 20 minutes.<\/jats:p>\n               <jats:p>RESULTS. The mean transdiaphragmatic pressure-time product was higher with volume targeting at 4 mL\/kg in comparison with baseline, regardless of the patient-triggered mode. The transdiaphragmatic pressure-time product was higher at a volume-targeted level of 4 mL\/kg in comparison with 5 mL\/kg and at 5 mL\/kg in comparison with 6 mL\/kg. The mean work of breathing was below that at baseline only at a volume-targeted level of 6 mL\/kg.<\/jats:p>\n               <jats:p>CONCLUSIONS. Low volume-targeted levels increase the work of breathing during volume-targeted ventilation. Our results suggest that, during weaning, a volume-targeted level of 6 mL\/kg, rather than a lower level, could be used to avoid an increase in the work of breathing.<\/jats:p>","DOI":"10.1542\/peds.2008-2635","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T01:46:02Z","timestamp":1236044762000},"page":"e679-e684","source":"Crossref","is-referenced-by-count":47,"title":["Work of Breathing and Different Levels of Volume-Targeted Ventilation"],"prefix":"10.1542","volume":"123","author":[{"given":"Deena-Shefali","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Asthma, Allergy, and Lung Biology, King's College London School of Medicine, and Department of Child Health, King's College Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy, and Lung Biology, King's College London School of Medicine, and Department of Child Health, King's College Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Prendergast","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy, and Lung Biology, King's College London School of Medicine, and Department of Child Health, King's College Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrard F.","family":"Rafferty","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy, and Lung Biology, King's College London School of Medicine, and Department of Child Health, King's College Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy, and Lung Biology, King's College London School of Medicine, and Department of Child Health, King's College Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,4,1]]},"reference":[{"key":"2021120902370186700_R1","doi-asserted-by":"crossref","unstructured":"Dawson C, Davies MW. 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