{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:23:34Z","timestamp":1769855014609,"version":"3.49.0"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:p>OBJECTIVES: The goals were to identify and to classify causes and growth patterns of acquired (or progressive) microcephaly and to look for hypothesized correlations between causes, growth patterns, and developmental quotient\/IQ.<\/jats:p>\n               <jats:p>METHODS: Fifty-one children (24 boys), 0.7 to 11.3 years of age, with early occipitofrontal circumference measurements above and later ones below the second percentile (SD: \u22122.03) were studied through retrospective note and growth chart review, with formal assessments of developmental quotient or IQ (n = 34).<\/jats:p>\n               <jats:p>RESULTS: Causes were classifiable into 5 groups as follows: idiopathic, familial, syndromic, symptomatic, and mixed. Four patterns of head growth were identified, as follows: type A, initial decrease from the normal range to below the second percentile, followed by growth below and parallel to the second percentile; type B, continued decrease away from the second percentile; type C, decrease below the normal range, with partial later recovery; type D, insufficient data. For 12 children, there were accompanying decreases in weight percentiles and for 5 of these in height percentiles as well. Infants with lower head circumference z scores at the end of the study also had lower z scores for final weight and final length. There was no correlation between causal group and growth pattern. Developmental quotient\/IQ values were mostly &amp;lt;100 and did not correlate with head circumference z score, cause, or pattern.<\/jats:p>\n               <jats:p>CONCLUSIONS: The classification of causal groups and growth patterns should aid clinical management. Neither cause nor pattern predicted outcomes. The associations with poor weight gain and body growth deserve further study.<\/jats:p>","DOI":"10.1542\/peds.2008-2784","type":"journal-article","created":{"date-parts":[[2009,7,27]],"date-time":"2009-07-27T11:32:55Z","timestamp":1248694375000},"page":"590-595","source":"Crossref","is-referenced-by-count":31,"title":["Acquired Microcephaly: Causes, Patterns, Motor and IQ Effects, and Associated Growth Changes"],"prefix":"10.1542","volume":"124","author":[{"given":"Peter Stuart","family":"Baxter","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Sheffield Children's National Health Service Foundation Trust, Sheffield, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Steven","family":"Rigby","sequence":"additional","affiliation":[{"name":"Department of Academic Cardiology (Statistics), University of Hull, Hull, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne He\u0301le\u0300ne Elise Pascale Dominique","family":"Rotsaert","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Sheffield, Sheffield, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingram","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Sheffield, Sheffield, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2021120905285996100_R1","unstructured":"Opitz JM, Holt MC. 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