{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:54:46Z","timestamp":1771329286335,"version":"3.50.1"},"reference-count":39,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:p>OBJECTIVE: To identify changes in temperature, fluid and electrolyte management, growth, and short-term outcome in extremely low birth weight (ELBW) infants nursed in humidified hybrid incubators (HI group) compared with a cohort of patients cared for in nonhumidified conventional incubators (CI group).<\/jats:p><jats:p>METHODS: Body temperature (BT), fluid and electrolyte balance, and growth velocity (GV) were collected retrospectively on 182 ELBW infants. The CI group included ELBW infants cared for with radiant warmers followed by an incubator without humidity. The HI group included ELBW infants cared for in the radiant warmer mode in a Giraffe OmniBed, followed by the incubator mode using high humidity.<\/jats:p><jats:p>RESULTS: The CI group included more multiple births (50.6%) than the HI group (35.8%; P &amp;lt; .05), but there was no difference in demographic characteristics. BT was similar during the first week. The HI group had less fluid intake, urine output, and insensible water loss, less maximum weight loss, and a lower incidence of hypernatremia during the first week than did the CI group (P &amp;lt; .05). The HI group also had a lower frequency of electrolyte sampling and packed red cell transfusion (P &amp;lt; .05), a higher incidence of hyponatremia on postnatal day 1 than the CI group (P &amp;lt; .05), and a higher GV than the CI group (15.2 \u00b1 5.0 vs 13.5 \u00b1 4.8 g\/kg per day), especially among those with a birth weight of \u2264749 g (P &amp;lt; .01). There was no difference in sepsis, necrotizing enterocolitis, intraventricular hemorrhage, and all bronchopulmonary dysplasia (BPD), but there was a decreased incidence of severe BPD (5.1% [HI] vs 16.4% [CI]; P &amp;lt; .05) and duration of assisted ventilation in the HI group compared with the CI group (15.5 \u00b1 2.1 vs 19.6 \u00b1 2.4 days, respectively; P = .068).<\/jats:p><jats:p>CONCLUSIONS: Use of a humidified hybrid incubator improved care for ELBW infants by making it possible to decrease fluid intake, improve electrolyte balance, and enhance GV without a disturbance of BT compared with conventional care. By adjusting fluid intake when using these devices, benefits may be enhanced and the risk of BPD and severe BPD may be reduced.<\/jats:p>","DOI":"10.1542\/peds.2008-2997","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T01:34:22Z","timestamp":1261445662000},"page":"e137-e145","source":"Crossref","is-referenced-by-count":48,"title":["Improved Care and Growth Outcomes by Using Hybrid Humidified Incubators in Very Preterm Infants"],"prefix":"10.1542","volume":"125","author":[{"given":"Sung Mi","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Pediatrics, Busan St Mary's Hospital, Busan, Korea"},{"name":"Department of Pathology, School of Medicine, Pusan National University, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Massachusetts, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Alan","family":"Ringer","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"2021120821190554000_R1","doi-asserted-by":"crossref","unstructured":"Lemons JA, Bauer CR, Oh W, et al. 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J Pediatr.\u20081962;60:889\u2013894","DOI":"10.1016\/S0022-3476(62)80174-7"},{"key":"2021120821190554000_R5","doi-asserted-by":"crossref","unstructured":"Buetow KC, Klein SW. Effect of maintenance of \u201cnormal\u201d skin temperature on survival of infants of low birth weight. Pediatrics.\u20081964;34(2):163\u2013170","DOI":"10.1542\/peds.34.2.163"},{"key":"2021120821190554000_R6","unstructured":"Bell EF, Glatzl-Hawlik MA. Environmental temperature control. In: Polin RA, Fox WW, eds. Fetal and Neonatal Physiology. 2nd ed. Philadelphia, PA: W.B. Saunders; 1998:716\u2013727"},{"key":"2021120821190554000_R7","unstructured":"Gomella TL. Fluids and electrolytes. In: Gomella TL, Cunningham MD, Eyal FG, Zenk KE, eds. Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs. New York, NY: McGraw-Hill; 2004:69\u201376"},{"key":"2021120821190554000_R8","doi-asserted-by":"crossref","unstructured":"Hammarlund K, Sedin G. Transepidermal water loss in newborn infants. III. 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Pediatrics.\u20081984;74(6):1022\u20131028","DOI":"10.1542\/peds.74.6.1022"},{"key":"2021120821190554000_R12","doi-asserted-by":"crossref","unstructured":"Bhandari V, Brodsky N, Porat R. Improved outcome of extremely low birth weight infants with Tegaderm application to skin. J Perinatol.\u20082005;25(4):276\u2013281","DOI":"10.1038\/sj.jp.7211260"},{"key":"2021120821190554000_R13","doi-asserted-by":"crossref","unstructured":"Nopper AJ, Horii KA, Sookdeo-Drost S, Wang TH, Mancini AJ, Lane AT. Topical ointment therapy benefits premature infants. J Pediatr.\u20081996;128(5 pt 1):660\u2013669","DOI":"10.1016\/S0022-3476(96)80132-6"},{"key":"2021120821190554000_R14","doi-asserted-by":"crossref","unstructured":"Pabst RC, Starr KP, Qaiyumi S, Schwalbe RS, Gewolb IH. The effect of application of aquaphor on skin condition, fluid requirements, and bacterial colonization in very low birth weight infants. 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Arch Dis Child.\u20081979;54(11):858\u2013868","DOI":"10.1136\/adc.54.11.858"},{"key":"2021120821190554000_R37","doi-asserted-by":"crossref","unstructured":"Hammarlund K, Sedin G, Stromberg B. Transepidermal water loss in newborn infants. VII. Relation to post-natal age in very pre-term and full-term appropriate for gestational age infants. Acta Paediatr Scand.\u20081982;71(3):369\u2013374","DOI":"10.1111\/j.1651-2227.1982.tb09436.x"},{"key":"2021120821190554000_R38","doi-asserted-by":"crossref","unstructured":"Cartlidge P. The epidermal barrier. Semin Neonatol.\u20082000;5(4):273\u2013280","DOI":"10.1053\/siny.2000.0013"},{"key":"2021120821190554000_R39","unstructured":"Barnette AR, Inder TE. Hypernatremia in prematurity: a risk factor for severe intraventricular hemorrhages. 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