{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:12:27Z","timestamp":1793761947192,"version":"4.6.1"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:p>OBJECTIVE: To describe the prevalence and clinical characteristics of transient hyperphosphatasemia (TH) in a cohort of healthy infants and toddlers.<\/jats:p><jats:p>METHODS: We performed a secondary data analysis of healthy infants and toddlers enrolled in a study examining the epidemiology of vitamin D deficiency. From 2005 to 2007, children aged 8 to 24 months were enrolled during well-child visits at an urban primary care pediatric clinic. At enrollment, we collected data regarding sociodemographic and clinical characteristics. We measured serum levels of alkaline phosphatase (AP), 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, magnesium, and phosphorus. We placed participants into 1 of 3 categories on the basis of serum AP levels: normal (AP: 110\u2013400 U\/L), intermediate (AP: &amp;gt;400 to 1000 U\/L), and TH (AP: &amp;gt;1000 U\/L). We used Fisher's exact test and analysis of variance to evaluate differences in characteristics among the 3 groups.<\/jats:p><jats:p>RESULTS: Nine (2.8%) of 316 children had an AP level of &amp;gt;1000 U\/L (mean: 2165 U\/L). Sixteen children (5.1%) had an intermediate serum AP level (mean: 544 U\/L). Mean weight-for-age, length-for-age, and weight-for-length z scores were similar across all 3 AP groups. Compared with the 291 children without TH, children in the intermediate AP and TH groups had similar mean serum levels of 25-hydroxyvitamin D, PTH, calcium, magnesium, and phosphorus.<\/jats:p><jats:p>CONCLUSIONS: TH seems to be a relatively common condition among healthy infants and toddlers. TH was not associated with anthropometric measures, vitamin D status, PTH, or serum minerals. Recognition of this benign condition is important to avoid unnecessary investigations.<\/jats:p>","DOI":"10.1542\/peds.2008-3093","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:34:48Z","timestamp":1248136488000},"page":"703-709","source":"Crossref","is-referenced-by-count":50,"title":["Prevalence of Transient Hyperphosphatasemia Among Healthy Infants and Toddlers"],"prefix":"10.1542","volume":"124","author":[{"given":"Susanna Y.","family":"Huh","sequence":"first","affiliation":[{"name":"Divisions of Gastroenterology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Clinical Research Program, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne E.","family":"Cox","sequence":"additional","affiliation":[{"name":"General Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Adolescent Medicine"},{"name":"Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2021120905292701200_R1","doi-asserted-by":"crossref","unstructured":"Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child.\u20081985;139(7):736\u2013740","DOI":"10.1001\/archpedi.1985.02140090098042"},{"key":"2021120905292701200_R2","unstructured":"Griffiths J, Vernocchi A, Simoni E. Transient hyperphosphatasemia of infancy and childhood. A study of serum alkaline phosphatase by electrofocusing techniques. Arch Pathol Lab Med.\u20081995;119(9):784\u2013789"},{"key":"2021120905292701200_R3","doi-asserted-by":"crossref","unstructured":"Kutilek S, Bayer M. Transient hyperphosphatasaemia of infancy and early childhood\u2014clinical and laboratory data of 52 patients. J Paediatr Child Health.\u20082003;39(2):157","DOI":"10.1046\/j.1440-1754.2003.t01-1-00121.x"},{"key":"2021120905292701200_R4","doi-asserted-by":"crossref","unstructured":"Stein P, Rosalki SB, Foo AY, Hjelm M. Transient hyperphosphatasemia of infancy and early childhood: clinical and biochemical features of 21 cases and literature review. Clin Chem.\u20081987;33(2 pt 1):313\u2013318","DOI":"10.1093\/clinchem\/33.2.313"},{"key":"2021120905292701200_R5","doi-asserted-by":"crossref","unstructured":"Behu\u0301lova\u0301 D, Bzduch V, Holesova D, Vasilenkova A, Ponec J. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem.\u20082000;46(11):1868\u20131869","DOI":"10.1093\/clinchem\/46.11.1868"},{"key":"2021120905292701200_R6","doi-asserted-by":"crossref","unstructured":"Carroll AJ, Coakley JC. Transient hyperphosphatasaemia: an important condition to recognize. J Paediatr Child Health.\u20082001;37(4):359\u2013362","DOI":"10.1046\/j.1440-1754.2001.00686.x"},{"key":"2021120905292701200_R7","doi-asserted-by":"crossref","unstructured":"Crofton PM. What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem.\u20081988;34(2):335\u2013340","DOI":"10.1093\/clinchem\/34.2.335"},{"key":"2021120905292701200_R8","unstructured":"Asanti R, Hultin H, Visakorpi JK. Serum alkaline, phosphatase in healthy infants: occurrence of abnormally high values without known cause. Ann Paediatr Fenn.\u20081966;12(2):139\u2013142"},{"key":"2021120905292701200_R9","doi-asserted-by":"crossref","unstructured":"Gordon CM, Feldman HA, Sinclair L, et al. Prevalence of vitamin D deficiency among healthy infants and toddlers. Arch Pediatr Adolesc Med.\u20082008;162(6):505\u2013512","DOI":"10.1001\/archpedi.162.6.505"},{"key":"2021120905292701200_R10","unstructured":"Centers for Disease Control and Prevention, National Center for Health Statistics. 2000 CDC growth charts: United States. Available at: www.cdc.gov\/growthcharts. Accessed June 27, 2007"},{"key":"2021120905292701200_R11","doi-asserted-by":"crossref","unstructured":"Peterson KE, Chen LC. Defining undernutrition for public health purposes in the United States. J Nutr.\u20081990;120(8):933\u2013942","DOI":"10.1093\/jn\/120.8.933"},{"key":"2021120905292701200_R12","doi-asserted-by":"crossref","unstructured":"Weiber H, Fex G, Lindberg T, Skude G. Atypical, anodally migrating alkaline phosphatase isoenzyme in children and its relation to abdominal symptoms. Clin Chem.\u20081983;29(3):593\u2013595","DOI":"10.1093\/clinchem\/29.3.593"},{"key":"2021120905292701200_R13","doi-asserted-by":"crossref","unstructured":"Hoshino T, Kumasaka K, Kawano K, Yamagishi F, Sakai H, Komoda T. A case of benign familial hyperphosphatasemia of intestinal origin. Clin Biochem.\u20081993;26(5):421\u2013425","DOI":"10.1016\/0009-9120(93)90120-U"},{"key":"2021120905292701200_R14","doi-asserted-by":"crossref","unstructured":"Parker SG. Transient hyperphosphatasaemia in association with acute infection in adults. Postgrad Med J.\u20081991;67(789):638\u2013642","DOI":"10.1136\/pgmj.67.789.638"},{"key":"2021120905292701200_R15","doi-asserted-by":"crossref","unstructured":"Onica D, Torssander J, Waldenlind L. Recurrent transient hyperphosphatasemia of infancy in an adult. Clin Chem.\u20081992;38(9):1913\u20131915","DOI":"10.1093\/clinchem\/38.9.1913"},{"key":"2021120905292701200_R16","unstructured":"Richardson RW. Handbook of Nonpathologic Variations in Human Blood Constituents. Boca Raton, FL: CRC Press; 1994"},{"key":"2021120905292701200_R17","doi-asserted-by":"crossref","unstructured":"Kraut JR, Shah B. Simultaneous transient hyperphosphatasemia in a set of twins. Am J Dis Child.\u20081989;143(8):881\u2013882","DOI":"10.1001\/archpedi.1989.02150200017008"},{"key":"2021120905292701200_R18","doi-asserted-by":"crossref","unstructured":"Kutilek S, Bayer M, Markova D. Prospective follow-up of children with transient hyperphosphatasemia. Clin Pediatr (Phila).\u20081997;36(8):491\u2013492","DOI":"10.1177\/000992289703600815"},{"key":"2021120905292701200_R19","doi-asserted-by":"crossref","unstructured":"Kusel MM, de Klerk NH, Holt PG, Kebadze T, Johnston SL, Sly PD. Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study. Pediatr Infect Dis J.\u20082006;25(8):680\u2013686","DOI":"10.1097\/01.inf.0000226912.88900.a3"},{"key":"2021120905292701200_R20","doi-asserted-by":"crossref","unstructured":"Monto AS. Epidemiology of viral respiratory infections. Am J Med.\u20082002;112(suppl 6A):S4\u2013S12","DOI":"10.1016\/S0002-9343(01)01058-0"},{"key":"2021120905292701200_R21","unstructured":"Mandell GL, Douglas RG, Bennett JE, Dolin R. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 6th ed. New York, NY: Elsevier\/Churchill Livingstone; 2005"},{"key":"2021120905292701200_R22","doi-asserted-by":"crossref","unstructured":"Hardy AM, Lairson DR, Morrow AL. Costs associated with gastrointestinal-tract illness among children attending day-care centers in Houston, Texas. Pediatrics.\u20081994;94(6 pt 2):1091\u20131093","DOI":"10.1542\/peds.94.6.1091"},{"key":"2021120905292701200_R23","doi-asserted-by":"crossref","unstructured":"Abbassi V, Colon AR, Schwartz RH. Benign elevation of serum alkaline phosphatase, transient and persistent variety. Clin Pediatr (Phila).\u20081984;23(6):336\u2013337","DOI":"10.1177\/000992288402300607"},{"key":"2021120905292701200_R24","doi-asserted-by":"crossref","unstructured":"Tolaymat N, de Melo MC. Benign transient hyperphosphatasemia of infancy and childhood. South Med J.\u20082000;93(12):1162\u20131164","DOI":"10.1097\/00007611-200012000-00004"},{"key":"2021120905292701200_R25","unstructured":"Shils ME, Shike M. Modern Nutrition in Health and Disease. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006"},{"key":"2021120905292701200_R26","doi-asserted-by":"crossref","unstructured":"Kruse K. Normal bone turnover in isolated hyperphosphatasemia. J Pediatr.\u20081985;106(6):946\u2013948","DOI":"10.1016\/S0022-3476(85)80247-X"},{"key":"2021120905292701200_R27","doi-asserted-by":"crossref","unstructured":"Stepan JJ, Kutilek S, Bayer M. Transient hyperphosphatasaemia in infancy associated with an increased urinary hydroxyproline excretion. Clin Chim Acta.\u20081995;233(1\u20132):115\u2013118","DOI":"10.1016\/0009-8981(94)05956-S"},{"key":"2021120905292701200_R28","unstructured":"Kruse K, Reiss I, Inderrieden D, Kutilek S, Acil Y, Agbenu J. Biochemical markers of bone turnover in disease of extracellular calcium and phosphate metabolism. In: Scho\u0308nau E, ed. Paediatric Osteology: New Developments in Diagnostics and Therapy: Proceedings of the First International Workshop on Paediatric Osteology, October 5\u20137, 1995, Cologne, Germany. New York, NY: Elsevier; 1996:203\u2013220"},{"key":"2021120905292701200_R29","doi-asserted-by":"crossref","unstructured":"Eyre D. New biomarkers of bone resorption. J Clin Endocrinol Metab.\u20081992;74(3):470A\u2013470C","DOI":"10.1210\/jcem.74.3.1740477"},{"key":"2021120905292701200_R30","doi-asserted-by":"crossref","unstructured":"Ranchin B, Villard F, Andre JL, et al. Transient hyperphosphatasemia after organ transplantation in children. Pediatr Transplant.\u20082002;6(4):308\u2013312","DOI":"10.1034\/j.1399-3046.2002.02016.x"},{"key":"2021120905292701200_R31","doi-asserted-by":"crossref","unstructured":"Schwab M, Schmidt-Gayk H, Ruder H. Transient hyperphosphatasaemia in a 4-year-old boy after successful kidney transplantation. 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