{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:03:38Z","timestamp":1765609418546,"version":"3.40.5"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>An apparent life-threatening event (ALTE) caused by ingestion of drugs or toxins has been reported rarely among infants. None of these agents was homeopathic medication. We report 11 infants who presented with an ALTE after ingestion of Gali-col Baby, a homeopathic agent indicated for \u201cinfantile colic.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A retrospective case-control study was conducted. Charts of all infants who were younger than 1 year and were admitted with an ALTE from January 2005 through August 2008 to the pediatric division at the Barzilai Medical Center were reviewed. Age-matched infants who were admitted on the same dates for a reason other than ALTE served as a control group. Information on medications administered before admission was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>During the study period, 36 635 children visited the pediatric emergency department of the Barzilai Medical Center. There were 11 057 admissions to the pediatric division during this period, 115 of which were because of an ALTE. Eleven of these infants received Gali-col Baby before the event as opposed to none in the control group (P &amp;lt; .005). Three infants received a significant overdose, compared with the manufacturer's recommended dosage. After a thorough investigation, no other presumptive causes for ALTE were found among the 11 infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Gali-col Baby is associated with an ALTE in some infants. There are no published controlled trials on the efficacy or safety of its use; therefore, better control and supervision of Gali-col Baby and probably other homeopathic medications are needed to prevent possible serious adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2008-3515","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T01:34:53Z","timestamp":1264469693000},"page":"e318-e323","source":"Crossref","is-referenced-by-count":23,"title":["Use of a Homeopathic Preparation for \u201cInfantile Colic\u201d and an Apparent Life-Threatening Event"],"prefix":"10.1542","volume":"125","author":[{"given":"Shraga","family":"Aviner","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Barzilai Medical Center, Ashkelon, Israel;"},{"name":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matitiahu","family":"Berkovitch","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin, Israel;"},{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedva","family":"Dalkian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Barzilai Medical Center, Ashkelon, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rony","family":"Braunstein","sequence":"additional","affiliation":[{"name":"Independent Statistical Consultant, Tel Aviv, Israel; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossef","family":"Lomnicky","sequence":"additional","affiliation":[{"name":"Maccabi Healthcare Services, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menachem","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Barzilai Medical Center, Ashkelon, Israel;"},{"name":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"issue":"2","key":"2021120905130651600_B1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1542\/peds.79.2.292","volume":"79","year":"1987","journal-title":"Pediatrics"},{"issue":"1","key":"2021120905130651600_B2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/emj.19.1.11","article-title":"Apparent life threatening events in infants presenting to an emergency department","volume":"19","author":"Davies","year":"2002","journal-title":"Emerg Med J"},{"issue":"5","key":"2021120905130651600_B3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/000992289103000503","article-title":"Colic medication and apparent life-threatening events","volume":"30","author":"Hardoin","year":"1991","journal-title":"Clin Pediatr (Phila)"},{"issue":"5","key":"2021120905130651600_B4","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1542\/peds.83.5.772","article-title":"Parental administration of chemical agents: a cause of apparent life-threatening events","volume":"83","author":"Hickson","year":"1989","journal-title":"Pediatrics"},{"issue":"7","key":"2021120905130651600_B5","first-page":"451","article-title":"Apropos of 100 cases of malaise in infants [in French]","volume":"36","author":"Laisne","year":"1989","journal-title":"Ann Pediatr (Paris)"},{"issue":"11","key":"2021120905130651600_B6","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1136\/adc.2003.031740","article-title":"Causes of apparent life threatening events in infants: a systematic review","volume":"89","author":"McGovern","year":"2004","journal-title":"Arch Dis Child"},{"issue":"2","key":"2021120905130651600_B7","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2007-3729","article-title":"Accidental and nonaccidental poisonings as a cause of apparent life-threatening events in infants","volume":"122","author":"Pitetti","year":"2008","journal-title":"Pediatrics"},{"issue":"3","key":"2021120905130651600_B8","first-page":"521","article-title":"Alternative and complementary therapies","volume":"17","author":"Breuner","year":"2006","journal-title":"Adolesc Med Clin"},{"issue":"1","key":"2021120905130651600_B9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1542\/peds.70.1.32","article-title":"Intentional poisoning of children: an overlooked category of child abuse\u2014report of seven cases and review of the literature","volume":"70","author":"Dine","year":"1982","journal-title":"Pediatrics"},{"issue":"3","key":"2021120905130651600_B10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00005176-199104000-00005","article-title":"Gastroesophageal reflux in infants with a history of near-miss sudden infant death","volume":"12","author":"Veereman-Wauters","year":"1991","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"2021120905130651600_B11","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2008-3075","article-title":"Apparent life-threatening events and over-the-counter cough and cold medications: in reply","volume":"123","author":"Pitetti","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"2021120905130651600_B12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0021-9975(83)90063-4","article-title":"Toxicity of five Sudanese plants to young ruminants","volume":"93","author":"Barri","year":"1983","journal-title":"J Comp Pathol"},{"issue":"3","key":"2021120905130651600_B13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1078\/0940-2993-00252","article-title":"In vitro investigation of a standardized dried extract of Citrullus colocynthis on liver toxicity in adult rats","volume":"54","author":"Barth","year":"2002","journal-title":"Exp Toxicol Pathol"},{"issue":"8","key":"2021120905130651600_B14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1191\/0960327102ht259cr","article-title":"Herbal medicine causing likely strychnine poisoning","volume":"21","author":"Chan","year":"2002","journal-title":"Hum Exp Toxicol"},{"issue":"5","key":"2021120905130651600_B15","first-page":"195","article-title":"A case of Veratrum poisoning [in Italian]","volume":"62","author":"Festa","year":"1996","journal-title":"Minerva Anestesiol"},{"issue":"2","key":"2021120905130651600_B16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/15563658308990062","article-title":"Veratrum alkaloids in sneezing-powder a potential danger","volume":"20","author":"Fogh","year":"1983","journal-title":"J Toxicol Clin Toxicol"},{"issue":"10","key":"2021120905130651600_B17","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gut.30.10.1412","article-title":"Peculiar acute toxic colitis after ingestion of colocynth: a clinicopathological study of three cases","volume":"30","author":"Goldfain","year":"1989","journal-title":"Gut"},{"issue":"6","key":"2021120905130651600_B18","first-page":"36","article-title":"Electrocardiographic studies of patients with acute hellebore (Veratrum album) poisoning [in Bulgarian]","volume":"26","author":"Marinov","year":"1987","journal-title":"Vutr Boles"},{"issue":"3","key":"2021120905130651600_B19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00508-004-0291-x","article-title":"Dietary poisoning with Veratrum album: a report of two cases[in German]","volume":"117","author":"Zagler","year":"2005","journal-title":"Wien Klin Wochenschr"},{"issue":"9","key":"2021120905130651600_B20","first-page":"917","article-title":"Apparent intentional poisoning of an infant with acetaminophen","volume":"137","author":"Hickson","year":"1983","journal-title":"Am J Dis Child"},{"issue":"2","key":"2021120905130651600_B21","first-page":"375","article-title":"Possible dangers for patients using homeopathy: may a homeopathic medicinal product contain active substances that are not homeopathic dilutions?","volume":"26","author":"Cuesta Laso","year":"2007","journal-title":"Med Law"},{"issue":"2","key":"2021120905130651600_B22","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2007-3813","article-title":"Unexpected infant deaths associated with use of cough and cold medications","volume":"122","author":"Rimsza","year":"2008","journal-title":"Pediatrics"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/125\/2\/e318\/1101705\/zpe0021000e318.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/125\/2\/e318\/1101705\/zpe0021000e318.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T19:11:50Z","timestamp":1685387510000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/125\/2\/e318\/72004\/Use-of-a-Homeopathic-Preparation-for-Infantile"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,1]]},"published-print":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2008-3515","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2010,2,1]]}}}