{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:56:32Z","timestamp":1761310592956,"version":"3.40.5"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:p>OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of home pramlintide use in adolescents with type 1 diabetes.<\/jats:p>\n               <jats:p>PATIENTS AND METHODS: This was a randomized, 28-day pilot trial of pramlintide (maximum dose: 30 \u03bcg per meal) in 10 adolescents aged 13 to 17 years. End points included changes in hemoglobin A1c (HbA1c) values, body weight, and postprandial peak blood glucose levels and area under the curve on continuous glucose monitoring.<\/jats:p>\n               <jats:p>RESULTS: Changes in HbA1c values, body weight, and total insulin dose declined in the treatment group compared with the control group (bootstrapped, P \u2264 .02 for each). The treatment group also demonstrated lower average dinner area under the curve (P = .02) and lower maximum breakfast (P = .03) and dinner (P = .02) postprandial blood glucose values.<\/jats:p>\n               <jats:p>CONCLUSIONS: Pramlintide can help some adolescents to decrease postprandial hyperglycemia, HbA1c values, body weight, and insulin dosages. Additional large-scale trials should now be considered.<\/jats:p>","DOI":"10.1542\/peds.2008-3750","type":"journal-article","created":{"date-parts":[[2009,10,26]],"date-time":"2009-10-26T11:32:53Z","timestamp":1256556773000},"page":"1344-1347","source":"Crossref","is-referenced-by-count":18,"title":["A Pilot Trial of Pramlintide Home Usage in Adolescents With Type 1 Diabetes"],"prefix":"10.1542","volume":"124","author":[{"given":"Christopher M.","family":"Kishiyama","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Burdick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin C.","family":"Cobry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Gage","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel H.","family":"Messer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"McFann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Peter","family":"Chase","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"2021120905193540200_R1","doi-asserted-by":"crossref","unstructured":"Boland E, Monsod T, Delucia M, Brandt CA, Fernando S, Tamborlane WV. Limitations of conventional methods of self-monitoring of blood glucose. Diabetes Care.\u20082001;24(11):1858\u20131862","DOI":"10.2337\/diacare.24.11.1858"},{"key":"2021120905193540200_R2","doi-asserted-by":"crossref","unstructured":"Chase HP. Glycemic control in prepubertal years. Diabetes Care.\u20082003;26(4):1304\u20131305","DOI":"10.2337\/diacare.26.4.1304"},{"key":"2021120905193540200_R3","doi-asserted-by":"crossref","unstructured":"Koda JE, Fineman M, Rink TJ, Dailey GE, Muchmore DB, Linarelli LG. Amylin concentrations and glucose control. 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Pramlintide-lowered glucose excursions and was well-tolerated in adolescents with type 1 diabetes: results from a randomized, single-blind, placebo-controlled, crossover study. J Pediatr.\u20082009;155(3):368\u2013373.","DOI":"10.1016\/j.jpeds.2009.03.012"},{"key":"2021120905193540200_R10","doi-asserted-by":"crossref","unstructured":"Burdick J, Chase HP, Slover RH, et al. Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy. Pediatrics.\u20082004;113(3). Available at:www.pediatrics.org\/cgi\/content\/full\/113\/3\/e221","DOI":"10.1542\/peds.113.3.e221"},{"key":"2021120905193540200_R11","doi-asserted-by":"crossref","unstructured":"Neumark-Sztainer D, Patterson J, Mellin A, et al. Weight control practices and disordered eating behaviors among adolescent females and males with type 1 diabetes: associations with sociodemographics, weight concerns, familial factors, and metabolic outcomes. 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