{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T15:46:39Z","timestamp":1771688799851,"version":"3.50.1"},"reference-count":40,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:p>OBJECTIVE: The goal was to study exogenous surfactant disaturated phosphatidylcholine (DSPC) kinetics in preterm infants with respiratory distress syndrome (RDS) who were treated with 100 or 200 mg\/kg porcine surfactant.<\/jats:p><jats:p>METHODS: Sixty-one preterm infants with RDS undergoing mechanical ventilation received, within 24 hours after birth, 100 mg\/kg (N = 40) or 200 mg\/kg (N = 21) porcine surfactant mixed with [U-13C]dipalmitoylphosphatidylcholine. Clinical and respiratory parameters were recorded, and DSPC half-life and pool size and endogenous DSPC synthesis rate were calculated.<\/jats:p><jats:p>RESULTS: Clinical characteristics and short-term outcomes did not differ between groups. In the 100 mg\/kg group, 28 infants (70%) received a second dose after 25 \u00b1 11 hours and 9 (22.5%) a third dose after 41 \u00b1 11 hours; in the 200 mg\/kg group, 6 infants (28.6%) received a second dose after 33 \u00b1 8 hours and 1 a third dose. The DSPC half-life was longer in the 200 mg\/kg group (first dose: 32 \u00b1 19 vs 15 \u00b1 15 hours [P = .002]; second dose: 43 \u00b1 32 vs 21 \u00b1 13 hours [P = .025]). DSPC synthesis rates and pool sizes before the first and second doses did not differ between the groups. The 200 mg\/kg group exhibited a greater reduction in the oxygenation index than did the 100 mg\/kg group after the first (P = .009) and second (P = .018) doses.<\/jats:p><jats:p>CONCLUSIONS: Porcine surfactant given to preterm infants with RDS at a dose of 200 mg\/kg resulted in a longer DSPC half-life, fewer retreatments, and better oxygenation index values.<\/jats:p>","DOI":"10.1542\/peds.2009-0126","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:46:15Z","timestamp":1255394775000},"page":"e950-e957","source":"Crossref","is-referenced-by-count":50,"title":["Dosing of Porcine Surfactant: Effect on Kinetics and Gas Exchange in Respiratory Distress Syndrome"],"prefix":"10.1542","volume":"124","author":[{"given":"Paola Elisa","family":"Cogo","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Facco","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Simonato","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Verlato","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clementina","family":"Rondina","sequence":"additional","affiliation":[{"name":"Neonatal Division, Institute of Maternal-Infantile Sciences, Polytechnic University of Marche and University Hospital of Ancona, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Baritussio","sequence":"additional","affiliation":[{"name":"Medical and Surgical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna Maria","family":"Toffolo","sequence":"additional","affiliation":[{"name":"Information Engineering, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgilio Paolo","family":"Carnielli","sequence":"additional","affiliation":[{"name":"Neonatal Division, Institute of Maternal-Infantile Sciences, Polytechnic University of Marche and University Hospital of Ancona, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"2021120905195059600_R1","doi-asserted-by":"crossref","unstructured":"Rebello CM, Jobe AH, Eisele JW, Ikegami M. 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