{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:13:10Z","timestamp":1784005990669,"version":"3.55.0"},"reference-count":14,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n The survival rates after pediatric intestinal transplant according to underlying disease are unknown. The objective of our study was to describe the population of pediatric patients receiving an intestinal transplant and to evaluate survival according to specific disease condition.<\/jats:p>\n <\/jats:sec>\n \n PATIENTS:<\/jats:title>\n Pediatric patients (\u226421 years of age) with intestinal failure meeting criteria for intestinal transplant were included in the study.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n A retrospective review of the United Network for Organ Sharing intestinal transplant database (January 1, 1991, to May 16, 2008), including all pediatric transplant centers participating in the United Network for Organ Sharing, was conducted. The main outcome measures were survival and mortality.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Eight hundred fifty-two children received an intestinal transplant (54% male). Median age and weight at the time of transplant were 1 year (interquartile rage: 1\u20135) and 10.7 kg (interquartile rage: 7.8\u201321.7). Sixty-nine percent of patients also received a simultaneous liver transplant. The most common diagnoses among patients who received a transplant were gastroschisis (24%), necrotizing enterocolitis (15%), volvulus (14%), other causes of short-gut syndrome (19%), functional bowel syndrome (16%), and Hirschsprung disease (7%). The Kaplan-Meier curves demonstrated variation in patient survival according to diagnosis. Cox regression analysis confirmed a survival difference according to diagnosis (P &lt; .001) and demonstrated a survival advantage for those patients listed with a diagnosis of volvulus (P &lt; .01) compared with the reference gastroschisis. After adjusting for gender, recipient weight, and concomitant liver transplant, children with volvulus had a lower hazard ratio for survival and a lower risk of mortality.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Survival after intestinal transplant was associated with the underlying disease state. The explanation for these findings requires additional investigation into the differences in characteristics of the population of children with intestinal failure.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2009-1713","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T01:25:17Z","timestamp":1265678717000},"page":"e550-e558","source":"Crossref","is-referenced-by-count":61,"title":["Outcomes in Children After Intestinal Transplant"],"prefix":"10.1542","volume":"125","author":[{"given":"Oliver B.","family":"Lao","sequence":"first","affiliation":[{"name":"Departments of General, Thoracic and Transplant Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Healey","sequence":"additional","affiliation":[{"name":"Departments of General, Thoracic and Transplant Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Departments of General, Thoracic and Transplant Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Horslen","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge D.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Departments of General, Thoracic and Transplant Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Goldin","sequence":"additional","affiliation":[{"name":"Departments of General, Thoracic and Transplant Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2010,3,1]]},"reference":[{"issue":"2","key":"2021120905425829300_B1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/01.mog.0000153313.43574.1b","article-title":"Intestinal transplantation: an update","volume":"21","author":"Fryer","year":"2005","journal-title":"Curr Opin Gastroenterol"},{"issue":"7","key":"2021120905425829300_B2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/00007890-199904150-00021","article-title":"Intestinal transplantation: 1997 report of the international registry. Intestinal Transplant Registry","volume":"67","author":"Grant","year":"1999","journal-title":"Transplantation"},{"issue":"1","key":"2021120905425829300_B3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-3468(99)90223-3","article-title":"Factors impacting the survival of children with intestinal failure referred for intestinal transplantation","volume":"34","author":"Bueno","year":"1999","journal-title":"J Pediatr Surg"},{"issue":"2","key":"2021120905425829300_B4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.105.2.e25","article-title":"Intestinal transplantation for short gut syndrome attributable to necrotizing enterocolitis","volume":"105","author":"Vennarecci","year":"2000","journal-title":"Pediatrics"},{"key":"2021120905425829300_B5","unstructured":"US Department of Health and Human Services, Health Resources and Services Administration\/Organ Procurement and Transplantation Network. Uniting people and information to help save lives. Available at: http:\/\/optn.transplant.hrsa.gov. Accessed May 16, 2008"},{"issue":"4 pt 2","key":"2021120905425829300_B6","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1600-6143.2008.02172.x","article-title":"Pediatric transplantation in the United States, 1997\u20132006","volume":"8","author":"Magee","year":"2008","journal-title":"Am J Transplant"},{"key":"2021120905425829300_B7","unstructured":"Intestinal Transplant Registry. An international collaboration of centers performing intestinal transplant. Available at: www.intestinaltransplant.org. Accessed May 16, 2008"},{"issue":"10","key":"2021120905425829300_B8","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.healun.2008.07.003","article-title":"Late outcomes of pediatric heart transplantation are independent of pre-transplant diagnosis and prior cardiac surgical intervention","volume":"27","author":"Dionigi","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"2021120905425829300_B9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dld.2003.09.015","article-title":"Survival rate and prognostic factors in patients with intestinal failure","volume":"36","author":"Vantini","year":"2004","journal-title":"Dig Liver Dis"},{"issue":"3","key":"2021120905425829300_B10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1399-3046.2002.02003.x","article-title":"Pediatric intestinal transplantation: historical notes, principles and controversies","volume":"6","author":"Reyes","year":"2002","journal-title":"Pediatr Transplant"},{"issue":"9","key":"2021120905425829300_B11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/TP.0b013e31816dd236","article-title":"Factors affecting survival to intestinal transplantation in the very young pediatric patient","volume":"85","author":"Mian","year":"2008","journal-title":"Transplantation"},{"issue":"1","key":"2021120905425829300_B12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1053\/jpsu.2001.20046","article-title":"Long-term results of intestinal transplantation for pseudo-obstruction in children","volume":"36","author":"Iyer","year":"2001","journal-title":"J Pediatr Surg"},{"issue":"4","key":"2021120905425829300_B13","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/gut.45.4.570","article-title":"Intestinal transplantation in children with chronic intestinal pseudo-obstruction","volume":"45","author":"Sigurdsson","year":"1999","journal-title":"Gut"},{"issue":"2","key":"2021120905425829300_B14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1399-3046.2007.00811.x","article-title":"A national conference to determine research priorities in pediatric solid organ transplantation","volume":"12","author":"Bartosh","year":"2008","journal-title":"Pediatr Transplant"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/125\/3\/e550\/895207\/zpe0031000e550.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/125\/3\/e550\/895207\/zpe0031000e550.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T23:23:27Z","timestamp":1639092207000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/125\/3\/e550\/72689\/Outcomes-in-Children-After-Intestinal-Transplant"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,1]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,1]]},"published-print":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2009-1713","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,1]]}}}