{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:10:21Z","timestamp":1784740221224,"version":"3.55.0"},"reference-count":35,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:p>Patients with interleukin 12 (IL-12)p40 or IL-12 receptor \u03b21 (IL12R\u03b21) deficiencies are prone to develop infections caused by mycobacteria and salmonella; other infections have only been rarely observed. In this report we describe 2 unrelated patients with complete autosomal recessive IL12R\u03b21 deficiency who suffered from sepsis attributable to Klebsiella pneumoniae. A Mexican boy suffered from disseminated bacille Calmette-Gu\u00e9rin disease and infections caused by K pneumoniae and Candida albicans and had a fatal outcome. A Turkish girl living in France suffered from disseminated Nocardia nova infection and K pneumoniae sepsis. Therefore, Klebsiella infections should be considered in patients with IL12R\u03b21 deficiency. Conversely, IL12R\u03b21 deficiency should be considered in patients with unexplained klebsiellosis.<\/jats:p>","DOI":"10.1542\/peds.2009-2504","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T03:08:32Z","timestamp":1285038512000},"page":"e971-e976","source":"Crossref","is-referenced-by-count":33,"title":["Clinical Disease Caused by<i>Klebsiella<\/i>in 2 Unrelated Patients With Interleukin 12 Receptor \u03b21 Deficiency"],"prefix":"10.1542","volume":"126","author":[{"given":"Sigifredo","family":"Pedraza","sequence":"first","affiliation":[{"name":"Unit of Biochemistry, National Institute for Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Lezana","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Children's Hospital Federico G\u00f3mez, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina","family":"Samarina","sequence":"additional","affiliation":[{"name":"St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Aldana","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Children's Hospital Federico G\u00f3mez, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Institute for Respiratory Diseases, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Boisson-Dupuis","sequence":"additional","affiliation":[{"name":"St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Paris, France;"},{"name":"Necker Faculty, Paris Descartes University, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perle","family":"Pages","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Unit, Trousseau Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[{"name":"St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York;"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Paris, France;"},{"name":"Necker Faculty, Paris Descartes 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