{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:12:05Z","timestamp":1781784725472,"version":"3.54.5"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:p>We report here the case of a child with a known muscular abnormality and susceptibility to malignant hyperthermia who abruptly died after receiving a therapeutic dose of ondansetron. Also, we discuss the pharmacodynamic relationship of ondansetron to malignant hyperthermia in a susceptible host.<\/jats:p>","DOI":"10.1542\/peds.2009-2795","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T01:38:56Z","timestamp":1272937136000},"page":"e1514-e1517","source":"Crossref","is-referenced-by-count":21,"title":["Administration of Ondansetron Is Associated With Lethal Outcome"],"prefix":"10.1542","volume":"125","author":[{"given":"Blanca","family":"Gener","sequence":"first","affiliation":[{"name":"Clinical Genetics, Department of Pediatrics, Hospital de Cruces, Barakaldo, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrett M.","family":"Burns","sequence":"additional","affiliation":[{"name":"Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Griffin","sequence":"additional","affiliation":[{"name":"Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Boyer","sequence":"additional","affiliation":[{"name":"Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"issue":"5","key":"2021120905335197000_B1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jpeds.2008.07.050","article-title":"Antiemetic medications in children with presumed infectious gastroenteritis: pharmacoepidemiology in Europe and Northern America","volume":"153","author":"Pfeil","year":"2008","journal-title":"J Pediatr"},{"issue":"3","key":"2021120905335197000_B2","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005506.pub2","article-title":"Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents","author":"Alhashimi","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2021120905335197000_B3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2036.1997.97269000.x","article-title":"Antiemetic activity of ondansetron in acute gastroenteritis","volume":"11","author":"Cubeddu","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"issue":"16","key":"2021120905335197000_B4","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1056\/NEJMoa055119","article-title":"Oral ondansetron for gastroenteritis in a pediatric emergency department","volume":"354","author":"Freedman","year":"2006","journal-title":"N Engl J Med"},{"issue":"4","key":"2021120905335197000_B5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1067\/mem.2002.122706","article-title":"A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis","volume":"39","author":"Ramsook","year":"2002","journal-title":"Ann Emerg Med"},{"issue":"4","key":"2021120905335197000_B6","doi-asserted-by":"crossref","DOI":"10.1542\/peds.109.4.e62","article-title":"Ondansetron decreases vomiting associated with acute gastroenteritis: a randomized, controlled trial","volume":"109","author":"Reeves","year":"2002","journal-title":"Pediatrics"},{"issue":"4","key":"2021120905335197000_B7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2036.2006.03231.x","article-title":"Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children","volume":"25","author":"Szajewska","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"10","key":"2021120905335197000_B8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1197\/j.aem.2006.05.018","article-title":"Emergency department treatment of viral gastritis using intravenous ondansetron or dexamethasone in children","volume":"13","author":"Stork","year":"2006","journal-title":"Acad Emerg Med"},{"issue":"10","key":"2021120905335197000_B9","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1080\/15563650802304401","article-title":"Obtundation and seizure following ondansetron overdose in an infant","volume":"46","author":"George","year":"2008","journal-title":"Clin Toxicol (Phila)"},{"issue":"3","key":"2021120905335197000_B10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1176\/appi.psy.42.3.258","article-title":"Possible serotonin syndrome in association with 5-HT3 antagonist agents","volume":"42","author":"Turkel","year":"2001","journal-title":"Psychosomatics"},{"issue":"11","key":"2021120905335197000_B11","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJMra041867","article-title":"The serotonin syndrome","volume":"352","author":"Boyer","year":"2005","journal-title":"N Engl J Med"},{"issue":"2","key":"2021120905335197000_B12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/bja\/aeg172","article-title":"Effects of a 5HT2 receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia","volume":"91","author":"Gerbershagen","year":"2003","journal-title":"Br J Anaesth"},{"issue":"6","key":"2021120905335197000_B13","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1097\/00000542-199606000-00002","article-title":"Effects of the serotonin sub 2 receptor agonist DOI on skeletal muscle specimens from malignant-hyperthermia-susceptible patients","volume":"84","author":"Wappler","year":"1996","journal-title":"Anesthesiology"},{"issue":"12","key":"2021120905335197000_B14","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1001\/archneur.1985.04060110086024","article-title":"Severe multicore disease associated with reaction to anaesthesia","volume":"42","author":"Koch","year":"1985","journal-title":"Arch Neurol"},{"issue":"1","key":"2021120905335197000_B15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000077658","article-title":"Multi-minicore disease with susceptibility to malignant hyperthermia in pregnancy","volume":"58","author":"Osada","year":"2004","journal-title":"Gynecol Obstet Invest"},{"key":"2021120905335197000_B16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1750-1172-2-31","article-title":"Multiminicore disease","volume":"2","author":"Jungbluth","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"2021120905335197000_B17","year":"2006"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/125\/6\/e1514\/1089567\/zpe006100e1514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/125\/6\/e1514\/1089567\/zpe006100e1514.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T23:08:40Z","timestamp":1639091320000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/125\/6\/e1514\/72479\/Administration-of-Ondansetron-Is-Associated-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,6,1]]},"published-print":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2009-2795","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,1]]}}}