{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:56:09Z","timestamp":1761400569408,"version":"3.40.5"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>The pathophysiology of stroke-like episodes in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) remains unresolved. Possible mechanisms include mitochondrial angiopathy, cytopathy, or both, collectively resulting in cellular energy depletion. To clarify disease mechanisms, axonal excitability properties were investigated in a 10-year-old child with MELAS. Serial assessments during a stroke-like episode revealed reversible depolarization of the axonal membrane consistent with disruption of energy-dependent processes. Axonal parameters correlated with the clinical assessment of central dysfunction and biochemical measures of acidosis. Novel axonal excitability techniques have established acute, reversible ischemic-like depolarization that may serve as a surrogate marker of central events that develop during stroke-like episodes in MELAS.<\/jats:p>","DOI":"10.1542\/peds.2009-2930","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T03:27:41Z","timestamp":1280806061000},"page":"e734-e739","source":"Crossref","is-referenced-by-count":17,"title":["Acute, Reversible Axonal Energy Failure During Stroke-Like Episodes in MELAS"],"prefix":"10.1542","volume":"126","author":[{"given":"Michelle A.","family":"Farrar","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia, Randwick, Sydney, Australia;"},{"name":"School of Women's and Children's Health,"},{"name":"Department of Neurology, Sydney Children's Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy 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