{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:19:15Z","timestamp":1791299955165,"version":"4.1.0"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVES:<\/jats:title><jats:p>Studies conducted so far have found no statistically significant increased risk for cancer among children who are born after in vitro fertilization (IVF).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>We followed 26 692 children who were born after IVF during the years 1982\u20132005 by using the Swedish Cancer Register and compared the number of children who had cancer and were born after IVF with children who were not conceived by IVF. Adjustment was made for year of birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Maternal age, parity, smoking, subfertility, previous miscarriages, BMI, and multiple births did not significantly affect cancer risk in offspring. High birth weight, premature delivery, and the presence of respiratory diagnoses and low Apgar score were risk factors for cancer. We identified 53 cases of cancer in children who were born after IVF against 38 expected cases: 18 of them with hematologic cancer (15 of them acute lymphoblastic leukemia), 17 with eye or central nervous system tumors, and 12 with other solid cancers. There were 6 cases of Langerhans histiocytosis against 1.0 expected. The total cancer risk estimate was 1.42 (95% confidence interval: 1.09\u20131.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>We found a moderately increased risk for cancer in children who were conceived by IVF. Putative intermediary factors could be preterm birth and neonatal asphyxia.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2009-3225","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T00:35:53Z","timestamp":1279586153000},"page":"270-276","source":"Crossref","is-referenced-by-count":124,"title":["Cancer Risk in Children and Young Adults Conceived by In Vitro Fertilization"],"prefix":"10.1542","volume":"126","author":[{"given":"Bengt","family":"K\u00e4ll\u00e9n","sequence":"first","affiliation":[{"name":"Tornblad Institute, University of Lund, Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orvar","family":"Finnstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital, Link\u00f6ping, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lindam","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-G\u00f6sta","family":"Nygren","sequence":"additional","affiliation":[{"name":"IVF and Fertility Clinic, Sophiahemmet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra Otterblad","family":"Olausson","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"issue":"7","key":"2021120820152859000_B1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1080\/00016340701446231","article-title":"Population-based Swedish studies of outcomes after in vitro fertilisation","volume":"86","author":"Nygren","year":"2007","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"2021120820152859000_B2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/humrep\/15.3.604","article-title":"Incidence of cancer in children born after in-vitro fertilization","volume":"15","author":"Bruinsma","year":"2000","journal-title":"Hum Reprod"},{"issue":"11","key":"2021120820152859000_B3","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/humrep\/16.11.2451","article-title":"Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF","volume":"16","author":"Klip","year":"2001","journal-title":"Hum Reprod"},{"issue":"9190","key":"2021120820152859000_B4","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(99)04345-7","article-title":"Deliveries and children born after in vitro fertilization in Sweden, 1982\u20131995: a retrospective cohort study","volume":"354","author":"Bergh","year":"1999","journal-title":"Lancet"},{"issue":"4","key":"2021120820152859000_B5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/humrep\/17.4.929","article-title":"Hospital care utilization of infants born after IVF","volume":"17","author":"Ericson","year":"2002","journal-title":"Hum Reprod"},{"issue":"3","key":"2021120820152859000_B6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.fertnstert.2005.03.035","article-title":"In vitro fertilization in Sweden: child morbidity including cancer risk","volume":"84","author":"K\u00e4ll\u00e9n","year":"2005","journal-title":"Fertil Steril"},{"issue":"4","key":"2021120820152859000_B7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/ije\/28.4.631","article-title":"Association of childhood cancer with factors related to pregnancy and birth","volume":"28","author":"Sch\u00fcz","year":"1999","journal-title":"Int J Epidemiol"},{"issue":"12","key":"2021120820152859000_B8","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.0001-6349.2005.00858.x","article-title":"In vitro fertilization in Sweden: maternal characteristics","volume":"84","author":"K\u00e4ll\u00e9n","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2021120820152859000_B9","unstructured":"National Board of Health and Welfare, Centre for Epidemiology. 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