{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:31:59Z","timestamp":1791178319299,"version":"4.1.0"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"\n OBJECTIVES:<\/jats:title>\n The goals were to assess the degree of improvement of facial acne after treatment with the 0.04% tretinoin microsphere gel (TMG) among patients 8 to 12 years of age and to assess tolerability and safety.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n An open-label study was conducted with 40 patients 8 to 12 years of age (mean age: 10.7 years) with mild\/moderate acne, defined on the basis of Evaluator's Global Severity Score (EGSS) values between 2 and 3. Patients were treated with the 0.04% TMG for 12 weeks and were evaluated at baseline and weeks 3, 6, and 12. Primary end points were changes in EGSS and Alternative Evaluator's Global Severity Score values; the secondary efficacy end point was the Investigator's Global Evaluation of treatment responses at week 12.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n The mean EGSS value decreased significantly from baseline to week 12 (2.6 vs 2.1; P &lt; .001), with 75% of cases being graded as almost clear or mild. The mean Alternative Evaluator's Global Severity Score value decreased from 3.1 to 2.4 during the 12-week period (P &lt; .001). The mean Investigator's Global Evaluation score was 3.39 at week 12, indicating moderate improvement of acne. Treatment-associated adverse events were minimal, with mild skin irritation being most commonly recorded, generally in the first 3 weeks of therapy.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n The 0.04% TMG pump was effective and safe for the treatment of acne vulgaris in this 8- to 12-year-old population, and the treatment was generally well tolerated. Additional studies in this population are recommended, to confirm these results.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2009-3447","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T03:29:21Z","timestamp":1274758161000},"page":"e1316-e1323","source":"Crossref","is-referenced-by-count":19,"title":["Study of the Efficacy and Tolerability of 0.04% Tretinoin Microsphere Gel for Preadolescent Acne"],"prefix":"10.1542","volume":"125","author":[{"given":"Lawrence F.","family":"Eichenfield","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Dermatology, Rady Children's Hospital San Diego, University of California, San Diego, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Matiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Dermatology, Rady Children's Hospital San Diego, University of California, San Diego, California; 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