{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:10:36Z","timestamp":1791306636753,"version":"4.3.1"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>We aimed to correlate early imaging data with motor outcomes in a large, homogeneous, cohort of infants with neonatal (diagnosed before 29 days of life) arterial ischemic stroke (AIS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>From a prospective cohort of 100 children with neonatal AIS, we analyzed the MRI studies performed within the 28 first days of life for 80 infants evaluated at 2 years of age. The relationships between infarction location and corticospinal tract (CST) involvement and motor outcomes were studied<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Seventy-three infarctions involved the middle cerebral artery (MCA) territory. Of those, 50 were superficial infarctions, 5 deep infarctions, and 18 mixed infarctions. The CST was involved in 24 cases. Nineteen patients with MCA infarctions (26% [95% confidence interval: 16%\u201334%]) developed hemiplegia. Mixed infarctions (P &amp;lt; .0001) and CST involvement (P &amp;lt; .0001) were highly predictive of hemiplegia. In contrast, 88% of children with isolated superficial MCA infarctions did not exhibit impairment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Accurate prediction of motor outcomes can be obtained from early MRI scans after neonatal AIS. The absence of involvement of the CST resulted in normal motor development in 94% of cases. CST involvement resulted in congenital hemiplegia in 66% of cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2009-3611","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T03:08:32Z","timestamp":1285038512000},"page":"e912-e918","source":"Crossref","is-referenced-by-count":100,"title":["Motor Outcomes After Neonatal Arterial Ischemic Stroke Related to Early MRI Data in a Prospective Study"],"prefix":"10.1542","volume":"126","author":[{"given":"B\u00e9atrice","family":"Husson","sequence":"first","affiliation":[{"name":"Departments of Pediatric Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Hertz-Pannier","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research Unit U663, Paris, France;"},{"name":"Cognition and Behavior Laboratory, Institute of Psychology, Descartes University Paris, Paris, France;"},{"name":"Institute of Biomedical Engineering, 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France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Chabrier","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research Unit CIE3, Saint-Etienne, France; and"},{"name":"Neonatology Unit, and"},{"name":"Pediatric Intensive Care Unit, North Hospital, Saint-Etienne University Hospital Center, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the AVCnn Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"issue":"3","key":"2021121010242519400_B1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1542\/peds.2007-0336","article-title":"Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and 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