{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:06:54Z","timestamp":1781186814099,"version":"3.54.1"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:p>We review here 7 cases of neonatal transfusion-associated babesiosis at a NICU in the northeast United States. Transfusion from 2 infected units of blood resulted in the 7 cases described. The clinical presentation was highly variable in this cohort; the extremely low birth weight neonates were the most severely affected. Antibiotic therapy was effective in neonates with mild and asymptomatic infection; however, double-volume exchange blood transfusion with prolonged multidrug treatment was required for the 2 most severe cases. The risk of Babesia microti infection is not eliminated through current blood-bank practices. Neonatologists in endemic areas should have a high index of suspicion for babesiosis in premature infants exposed to blood transfusions.<\/jats:p>","DOI":"10.1542\/peds.2010-0502","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T04:51:34Z","timestamp":1315025494000},"page":"e1019-e1024","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Presentation and Treatment of Transfusion-Associated Babesiosis in Premature Infants"],"prefix":"10.1542","volume":"128","author":[{"given":"Kari A.","family":"Simonsen","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph I.","family":"Harwell","sequence":"additional","affiliation":[{"name":"Adult and Pediatric Infectious Diseases, Brown University, Providence, Rhode Island; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Lainwala","sequence":"additional","affiliation":[{"name":"Neonatology, Connecticut Children's Medical Center, Hartford, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"2021120823482918600_B1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.en.30.010185.002255","article-title":"Ecology of Ixodes dammini-borne human babesiosis and Lyme disease","volume":"30","author":"Spielman","year":"1985","journal-title":"Annu Rev Entomol"},{"issue":"3","key":"2021120823482918600_B2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1046\/j.1537-2995.2000.40030285.x","article-title":"Transfusion-associated transmission of babesiosis in New York state","volume":"40","author":"Linden","year":"2000","journal-title":"Transfusion"},{"issue":"12","key":"2021120823482918600_B3","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1111\/j.1537-2995.2009.02429.x","article-title":"Transfusion-transmitted babesiosis in the United States: summary of a workshop","volume":"49","author":"Gubernot","year":"2009","journal-title":"Transfusion"},{"issue":"3","key":"2021120823482918600_B4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1423-0410.2006.00740.x","article-title":"Babesiosis and blood transfusion: flying under the radar","volume":"90","author":"Leiby","year":"2006","journal-title":"Vox Sang"},{"issue":"1","key":"2021120823482918600_B5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/595010","article-title":"Babesia infection through blood transfusions: reports received by the US Food and Drug Administration, 1997\u20132007","volume":"48","author":"Gubernot","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"12","key":"2021120823482918600_B6","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1111\/j.1537-2995.2009.02380.x","article-title":"Transfusion-transmitted babesiosis in Rhode Island","volume":"49","author":"Asad","year":"2009","journal-title":"Transfusion"},{"issue":"4","key":"2021120823482918600_B7","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0022-3476(87)80552-8","article-title":"Transplacental\/perinatal babesiosis","volume":"110","author":"Esernio-Jenssen","year":"1987","journal-title":"J Pediatr"},{"issue":"1 pt 1","key":"2021120823482918600_B8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-3476(97)70143-4","article-title":"Vertically transmitted babesiosis","volume":"131","author":"New","year":"1997","journal-title":"J Pediatr"},{"issue":"10","key":"2021120823482918600_B9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/jama.281.10.927","article-title":"A cluster of transfusion-associated babesiosis cases traced to a single asymptomatic donor","volume":"281","author":"Dobroszycki","year":"1999","journal-title":"JAMA"},{"issue":"5","key":"2021120823482918600_B10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3201\/eid1505.070808","article-title":"Probable congenital babesiosis in infant, New Jersey, USA","volume":"15","author":"Sethi","year":"2009","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"2021120823482918600_B11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01.inf.0000195438.09628.b0","article-title":"Neonatal babesiosis: case report and review of the literature","volume":"25","author":"Fox","year":"2006","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"2021120823482918600_B12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/INF.0b013e3181c3c971","article-title":"Congenital babesiosis in a four-week-old female infant","volume":"29","author":"Aderinboye","year":"2010","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"2021120823482918600_B13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1542\/peds.91.3.523","article-title":"National survey of neonatal transfusion practices: I. 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