{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:24:41Z","timestamp":1789737881466,"version":"4.0.1"},"reference-count":21,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To determine if beneficial effects of a weight-management program could be sustained for up to 24 months in a randomized trial in an ethnically diverse obese population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS AND METHODS:<\/jats:title>\n                  <jats:p>There were 209 obese children (BMI &amp;gt; 95th percentile), ages 8 to 16 of mixed ethnic backgrounds randomly assigned to the intensive lifestyle intervention or clinic control group. The control group received counseling every 6 months, and the intervention group received a family-based program, which included exercise, nutrition, and behavior modification. Lifestyle intervention sessions occurred twice weekly for the first 6 months, then twice monthly for the second 6 months; for the last 12 months there was no active intervention. There were 174 children who completed the 12 months of the randomized trial. Follow-up data were available for 76 of these children at 24 months. There were no statistical differences in dropout rates among ethnic groups or in any other aspects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Treatment effect was sustained at 24 months in the intervention versus control group for BMI z score (\u22120.16 [95% confidence interval: \u22120.23 to \u22120.09]), BMI (\u22122.8 kg\/m2 [95% confidence interval: \u22124.0\u20131.6 kg\/m2]), percent body fat (\u22124.2% [95% confidence interval: \u22126.4% to \u22122.0%]), total body fat mass (\u22125.8 kg [95% confidence interval: \u22129.1 kg to \u22122.6 kg]), total cholesterol (\u221213.0 mg\/dL [95% confidence interval: \u221221.7 mg\/dL to \u22124.2 mg\/dL]), low-density lipoprotein cholesterol (\u221210.4 mg\/dL [95% confidence interval: \u221218.3 mg\/dL to \u22122.4 mg\/dL]), and homeostasis model assessment of insulin resistance (\u22122.05 [95% confidence interval: \u22122.48 to \u22121.75]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>This study, unprecedented because of the high degree of obesity and ethnically diverse backgrounds of children, reveals that benefits of an intensive lifestyle program can be sustained 12 months after completing the active intervention phase.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2010-0697","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T04:44:45Z","timestamp":1297140285000},"page":"402-410","source":"Crossref","is-referenced-by-count":175,"title":["Long-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population"],"prefix":"10.1542","volume":"127","author":[{"given":"Mary","family":"Savoye","sequence":"first","affiliation":[{"name":"Yale Center for Clinical Investigation and"},{"name":"Department of Pediatric Endocrinology and Diabetes Center and Department of Pediatrics, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Nowicka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes Center and Department of Pediatrics, Yale University, New Haven, Connecticut;"},{"name":"Childhood Obesity Unit, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes Center and Department of Pediatrics, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunkyung","family":"Yu","sequence":"additional","affiliation":[{"name":"Yale Center for Clinical Investigation and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Dziura","sequence":"additional","affiliation":[{"name":"Yale Center for Clinical Investigation and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Chavent","sequence":"additional","affiliation":[{"name":"University of New Haven, Department of Dietetics, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Children's University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Serrecchia","sequence":"additional","affiliation":[{"name":"Yale Center for Clinical Investigation and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Tamborlane","sequence":"additional","affiliation":[{"name":"Yale Center for Clinical Investigation and"},{"name":"Department of Pediatric Endocrinology and Diabetes Center and Department of Pediatrics, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Caprio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes Center and Department of Pediatrics, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"issue":"3","key":"2021121007020262600_B1","first-page":"CD001872","article-title":"Interventions for treating obesity in children","author":"Summerbell","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"2021121007020262600_B2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jada.2004.12.009","article-title":"Anthropometric and psychosocial changes in obese adolescents enrolled in a Weight Management Program","volume":"105","author":"Savoye","year":"2005","journal-title":"J Am Diet Assoc"},{"issue":"24","key":"2021121007020262600_B3","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1001\/jama.297.24.2697","article-title":"Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial","volume":"297","author":"Savoye","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"2021121007020262600_B4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2337\/dc08-0808","article-title":"Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth","volume":"32","author":"Shaw","year":"2009","journal-title":"Diabetes Care"},{"issue":"2","key":"2021121007020262600_B5","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2009-1955","article-title":"Effectiveness of weight management interventions in children: a targeted systematic review for the USPSTF","volume":"125","author":"Whitlock","year":"2010","journal-title":"Pediatrics"},{"issue":"1","key":"2021121007020262600_B6","first-page":"CD001872","article-title":"Interventions for treating obesity in children","author":"Oude Luttikhuis","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"2021121007020262600_B7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1037\/0022-006X.58.5.661","article-title":"Five-year follow-up of family-based behavioral treatments for childhood obesity","volume":"58","author":"Epstein","year":"1990","journal-title":"J Consult Clin Psychol"},{"issue":"19","key":"2021121007020262600_B8","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1001\/jama.1990.03450190051027","article-title":"Ten-year follow-up of behavioral, family-based treatment for obese children","volume":"264","author":"Epstein","year":"1990","journal-title":"JAMA"},{"issue":"5","key":"2021121007020262600_B9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1037\/0278-6133.13.5.373","article-title":"Ten-year outcomes of behavioral family-based treatment for childhood obesity","volume":"13","author":"Epstein","year":"1994","journal-title":"Health Psychol"},{"issue":"314","key":"2021121007020262600_B10","first-page":"1","article-title":"CDC growth charts: United States","author":"Kuczmarski","year":"2000","journal-title":"Adv Data"},{"issue":"7","key":"2021121007020262600_B11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"2021121007020262600_B12","volume-title":"Missing Data","author":"Allison","year":"2001"},{"key":"2021121007020262600_B13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1037\/1082-989X.2.1.64","article-title":"Application of random-effects pattern-mixture models for missing data in longitudinal studies","volume":"2","author":"Hedeker","year":"1997","journal-title":"Psychol Methods"},{"issue":"7","key":"2021121007020262600_B14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/jpepsy\/jsh054","article-title":"Inpatient treatment for children with obesity: weight loss, psychological well-being, and eating behavior","volume":"29","author":"Braet","year":"2004","journal-title":"J Pediatr Psychol"},{"issue":"4","key":"2021121007020262600_B15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.ijo.0802605","article-title":"Massive obesity in adolescents: dietary interventions and behaviours associated with weight regain at 2 y follow-up","volume":"28","author":"Rolland-Cachera","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"2","key":"2021121007020262600_B16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2003-38498","article-title":"Evaluation of an outpatient treatment program for obese children and adolescents [in German]","volume":"215","author":"Weyhreter","year":"2003","journal-title":"Klin Padiatr"},{"issue":"3","key":"2021121007020262600_B17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF03327547","article-title":"Efficacy of an internet-based behavioral weight loss program for overweight adolescent African-American girls","volume":"10","author":"Williamson","year":"2005","journal-title":"Eat Weight Disord"},{"issue":"7","key":"2021121007020262600_B18","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/oby.2006.140","article-title":"Two-year internet-based randomized controlled trial for weight loss in African-American girls","volume":"14","author":"Williamson","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"9388","key":"2021121007020262600_B19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(03)14364-4","article-title":"Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning","volume":"362","author":"Weiss","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"2021121007020262600_B20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/ajcn\/88.3.778","article-title":"Pre-teen insulin resistance predicts weight gain, impaired fasting glucose, and type 2 diabetes at age 18\u201319 y: a 10-y prospective study of black and white girls","volume":"88","author":"Morrison","year":"2008","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2021121007020262600_B21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2337\/dc09-1635","article-title":"Utility of childhood glucose homeostasis variables in predicting adult diabetes and related cardiometabolic risk factors: the Bogalusa Heart Study","volume":"33","author":"Nguyen","year":"2010","journal-title":"Diabetes Care"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/127\/3\/402\/909391\/zpe00311000402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/127\/3\/402\/909391\/zpe00311000402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T16:15:44Z","timestamp":1639152944000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/127\/3\/402\/65037\/Long-term-Results-of-an-Obesity-Program-in-an"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,1]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2010-0697","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,1]]}}}