{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:22:09Z","timestamp":1783556529127,"version":"3.55.0"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>The aim of this study was to determine the effects of repeated courses of prenatal corticosteroid therapy versus placebo on death or neurologic impairment among the children enrolled in the Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study, at 18 to 24 months of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>A total of 2305 infants were eligible for follow-up evaluation; 2104 infants (1069 in the prenatal corticosteroid therapy group and 1035 in the placebo group) were monitored. The primary outcome was death or neurologic impairment, defined as either cerebral palsy or cognitive delay, at 18 to 24 months of age. The secondary outcomes were measurements of growth (height, weight, and head circumference).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Children exposed to multiple courses of prenatal corticosteroid therapy had similar rates of death or neurologic impairment, compared with children exposed to placebo (148 children [13.8%] vs 142 children [13.7%]; odds ratio: 1.001[95% confidence interval: 0.75\u20131.30]; P = .95). They had a mean weight of 11.94 kg, compared with 12.14 kg in the placebo group (P = .04), a mean height of 85.51 cm, compared with 85.46 cm (P = .87), and a mean head circumference of 48.18 cm, compared with 48.25 cm (P = .45).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Multiple courses of prenatal corticosteroid therapy, given every 14 days, did not increase or decrease the risk of death or neurologic impairment at 18 to 24 months of age, compared with a single course of prenatal corticosteroid therapy. Continued follow-up monitoring of these children is necessary to assess neurobehavioral function, school performance, and possible susceptibility to disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2010-0857","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T02:31:59Z","timestamp":1287455519000},"page":"e1045-e1055","source":"Crossref","is-referenced-by-count":56,"title":["Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study: 2-Year Outcomes"],"prefix":"10.1542","volume":"126","author":[{"given":"Elizabeth V.","family":"Asztalos","sequence":"first","affiliation":[{"name":"Departments of Newborn and Developmental Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie E.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Hannah","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Willan","sequence":"additional","affiliation":[{"name":"Program in Child Health Evaluative Sciences, SickKids Research Institute, Dalla Lana School of Public Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Departments of Physiology,"},{"name":"Obstetrics and Gynecology, and"},{"name":"Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Paediatrics, Mount Sinai Hospital,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond N.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Paediatrics, Mount Sinai Hospital,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Saigal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University Medical Centre, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Calgary, Calgary, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Delisle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, British Columbia Women's Hospital, University of British Columbia, Vancouver, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kofi","family":"Amankwah","sequence":"additional","affiliation":[{"name":"Department of Gynecology-Obstetrics, Women's and Children's Hospital, State University of New York at Buffalo, Buffalo, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Guselle","sequence":"additional","affiliation":[{"name":"Centre for Mother, Infant, and Child Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiram","family":"Gafni","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoo K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Physiology,"},{"name":"Obstetrics and Gynecology, and"},{"name":"Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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